AutismKB 2.0

Annotation Details for PSMC1


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Basic Information Top
Gene Symbol:PSMC1 ( MGC24583,MGC8541,P26S4,S4,p56 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, ATPase, 1
Band: 14q32.11
Quick LinksEntrez ID:5700; OMIM: 602706; Uniprot ID:PRS4_HUMAN; ENSEMBL ID: ENSG00000100764; HGNC ID: 9547
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000502IDA-proteasome complex17323924
GO:0005634IDA-nucleus21630459
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0008540IBA-proteasome regulatory particle, base subcomplex-
GO:0016020IDA-membrane19946888
GO:0022624ISS-proteasome accessory complex-
GO:0031595IBA-nuclear proteasome complex-
GO:0031597IBA-cytosolic proteasome complex-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005515IPI-protein binding9452483
GO:0005524IEA-ATP binding-
GO:0016887ISS-ATPase activity1429620
GO:0017025IBA-TBP-class protein binding-
GO:0036402IBA-proteasome-activating ATPase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000209TAS-protein polyubiquitination-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0006457TAS-protein folding-
GO:0006521TAS-regulation of cellular amino acid metabolic process-
GO:0010972TAS-negative regulation of G2/M transition of mitotic cell cycle-
GO:0016579TAS-protein deubiquitination-
GO:0030433IBA-ubiquitin-dependent ERAD pathway-
GO:0031145TAS-anaphase-promoting complex-dependent catabolic process-
GO:0031146TAS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0038061TAS-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043488TAS-regulation of mRNA stability-
GO:0043687TAS-post-translational protein modification-
GO:0045899IBA-positive regulation of RNA polymerase II transcriptional preinitiation complex assembly-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051436TAS-negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0055085TAS-transmembrane transport-
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
GO:0090263TAS-positive regulation of canonical Wnt signaling pathway-
GO:1901215IEA-negative regulation of neuron death-
GO:1901800IEA-positive regulation of proteasomal protein catabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PSMC1PMS111167317148452 Affinity Capture-Western
PSMC1PMS111139117148452 Affinity Capture-Western
PSMC1PMS211140417148452 Affinity Capture-MS
PSMC1PMS211167317148452 Affinity Capture-MS
VCPPSMC11132589452483 Affinity Capture-Western
VCPPSMC11116739452483 Affinity Capture-Western
PSMC2PSMC111167310625621 11361004 Reconstituted Complex
PSMC2PSMC111167410625621 11361004 Reconstituted Complex
PSMD5PSMC111168410625621 Reconstituted Complex
PSMD5PSMC111167310625621 Reconstituted Complex
PSMD2PSMC111168110625621 16189514 Reconstituted Complex; Two-hybrid
PSMD2PSMC111167310625621 16189514 Reconstituted Complex; Two-hybrid
PSMC5PSMC111167811361004 Reconstituted Complex
PSMC5PSMC111167311361004 Reconstituted Complex
ATXN7PSMC111222111734547 Affinity Capture-Western; Co-fractionation; Two-hybrid
ATXN7PSMC111167311734547 Affinity Capture-Western; Co-fractionation; Two-hybrid
TRAF6PSMC111304114743216 Affinity Capture-MS
TRAF6PSMC111167314743216 Affinity Capture-MS
SRRM2PSMC111707116159877 Affinity Capture-MS
SRRM2PSMC111167316159877 Affinity Capture-MS
CCDC85BPSMC111167316189514 Two-hybrid
CCDC85BPSMC111619816189514 Two-hybrid
PSMC4PSMC111167717353931 Affinity Capture-MS
PSMC4PSMC111167317353931 Affinity Capture-MS
PSMD10PSMC111168817353931 Affinity Capture-MS
PSMD10PSMC111167317353931 Affinity Capture-MS
PSMD13PSMC111169117353931 Affinity Capture-MS
PSMD13PSMC111167317353931 Affinity Capture-MS
PAAF1PSMC112319117353931 Affinity Capture-MS
PAAF1PSMC111167317353931 Affinity Capture-MS
PSMD6PSMC111519517353931 Affinity Capture-MS
PSMD6PSMC111167317353931 Affinity Capture-MS
PSMD14PSMC111550819615732 Affinity Capture-MS
PSMD14PSMC111167319615732 Affinity Capture-MS
UCHL5PSMC111950919615732 Affinity Capture-MS
UCHL5PSMC111167319615732 Affinity Capture-MS
PSMD7PSMC111168519615732 Affinity Capture-MS
PSMD7PSMC111167319615732 Affinity Capture-MS
USP14PSMC111455119615732 Affinity Capture-MS
USP14PSMC111167319615732 Affinity Capture-MS
ATG4CPSMC111167320562859 Affinity Capture-MS
ATG4CPSMC112437220562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:106054
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-8730'