AutismKB 2.0

Annotation Details for PSMC3


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Basic Information Top
Gene Symbol:PSMC3 ( MGC8487,TBP1 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, ATPase, 3
Band: 11p11.2
Quick LinksEntrez ID:5702; OMIM: 186852; Uniprot ID:PRS6A_HUMAN; ENSEMBL ID: ENSG00000165916; HGNC ID: 9549
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000502IDA-proteasome complex17323924
GO:0000932ISS-P-body-
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus2194290
GO:0005654TAS-nucleoplasm-
GO:0005829TAS-cytosol-
GO:0008540IBA-proteasome regulatory particle, base subcomplex-
GO:0016020IDA-membrane19946888
GO:0022624ISS-proteasome accessory complex-
GO:0031595IBA-nuclear proteasome complex-
GO:0031597IBA-cytosolic proteasome complex-
GO:0034774TAS-secretory granule lumen-
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding16763564
GO:0005524IEA-ATP binding-
GO:0016887ISS-ATPase activity1429620
GO:0017025IBA-TBP-class protein binding-
GO:0036402IBA-proteasome-activating ATPase activity-
GO:0042802IPI-identical protein binding25416956
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000209TAS-protein polyubiquitination-
GO:0001824IEA-blastocyst development-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0006521TAS-regulation of cellular amino acid metabolic process-
GO:0010972TAS-negative regulation of G2/M transition of mitotic cell cycle-
GO:0016032IEA-viral process-
GO:0016579TAS-protein deubiquitination-
GO:0030433IBA-ubiquitin-dependent ERAD pathway-
GO:0031145TAS-anaphase-promoting complex-dependent catabolic process-
GO:0031146TAS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0038061TAS-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043312TAS-neutrophil degranulation-
GO:0043488TAS-regulation of mRNA stability-
GO:0043687TAS-post-translational protein modification-
GO:0043921IDA-modulation by host of viral transcription2194290
GO:0045899IBA-positive regulation of RNA polymerase II transcriptional preinitiation complex assembly-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter19853614
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051436TAS-negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0055085TAS-transmembrane transport-
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
GO:0090263TAS-positive regulation of canonical Wnt signaling pathway-
GO:1901800IEA-positive regulation of proteasomal protein catabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PSMC3CDKN2A11167517334400 Affinity Capture-Western
PSMC3CDKN2A10746317334400 Affinity Capture-Western
PSMC3EPAS110834814556007 Affinity Capture-Western
PSMC3EPAS111167514556007 Affinity Capture-Western
PSMC3HIF1A10933814556007 Affinity Capture-Western
PSMC3HIF1A11167514556007 Affinity Capture-Western
PSMC3HTR1E10958617353931 Affinity Capture-MS
PSMC3HTR1E11167517353931 Affinity Capture-MS
PSMC3PMS211167517148452 Affinity Capture-MS
PSMC3PMS211140417148452 Affinity Capture-MS
TXNRD2PSMC311167511463857 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TXNRD2PSMC311583611463857 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSMC5PSMC311167511463857 Reconstituted Complex; Two-hybrid
PSMC5PSMC311167811463857 Reconstituted Complex; Two-hybrid
VHLPSMC311326914556007 Affinity Capture-Western; Two-hybrid
VHLPSMC311167514556007 Affinity Capture-Western; Two-hybrid
TRAF6PSMC311304114743216 Affinity Capture-MS
TRAF6PSMC311167514743216 Affinity Capture-MS
STX11PSMC311422416169070 Two-hybrid
STX11PSMC311167516169070 Two-hybrid
PSMC4PSMC311167517353931 Affinity Capture-MS
PSMC4PSMC311167717353931 Affinity Capture-MS
PSMD10PSMC311167517353931 Affinity Capture-MS
PSMD10PSMC311168817353931 Affinity Capture-MS
PSMD13PSMC311169117353931 Affinity Capture-MS
PSMD13PSMC311167517353931 Affinity Capture-MS
PAAF1PSMC312319117353931 Affinity Capture-MS
PAAF1PSMC311167517353931 Affinity Capture-MS
PSMD6PSMC311519517353931 Affinity Capture-MS
PSMD6PSMC311167517353931 Affinity Capture-MS
UCHL5PSMC311167519615732 Affinity Capture-MS
UCHL5PSMC311950919615732 Affinity Capture-MS
PSMD7PSMC311167519615732 Affinity Capture-MS
PSMD7PSMC311168519615732 Affinity Capture-MS
USP14PSMC311455119615732 Affinity Capture-MS
USP14PSMC311167519615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1098754
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-666'