AutismKB 2.0

Annotation Details for PSMD8


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Basic Information Top
Gene Symbol:PSMD8 ( HIP6,HYPF,MGC1660,Nin1p,Rpn12,S14,p31 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Band: 19q13.2
Quick LinksEntrez ID:5714; OMIM: NA; Uniprot ID:PSMD8_HUMAN; ENSEMBL ID: ENSG00000099341; HGNC ID: 9566
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000502IDA-proteasome complex17323924
GO:0005634IDA-nucleus21630459
GO:0005654TAS-nucleoplasm-
GO:0005829IBA-cytosol-
GO:0005829TAS-cytosol-
GO:0005838TAS-proteasome regulatory particle7621825
GO:0008541IBA-proteasome regulatory particle, lid subcomplex-
GO:0022624ISS-proteasome accessory complex-
GO:0070062IDA-extracellular exosome23376485
No data
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000209TAS-protein polyubiquitination-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0006521TAS-regulation of cellular amino acid metabolic process-
GO:0010972TAS-negative regulation of G2/M transition of mitotic cell cycle-
GO:0016579TAS-protein deubiquitination-
GO:0031145TAS-anaphase-promoting complex-dependent catabolic process-
GO:0031146TAS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0031647IMP-regulation of protein stability24270810
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0038061TAS-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043161IBA-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043248IBA-proteasome assembly-
GO:0043488TAS-regulation of mRNA stability-
GO:0043687TAS-post-translational protein modification-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051436TAS-negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0055085TAS-transmembrane transport-
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
GO:0090263TAS-positive regulation of canonical Wnt signaling pathway-
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24270810
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UCHL5PSMD811168611163772 Reconstituted Complex; Two-hybrid
UCHL5PSMD811950911163772 Reconstituted Complex; Two-hybrid
PSMD13PSMD811169117353931 Affinity Capture-MS
PSMD13PSMD811168617353931 Affinity Capture-MS
PAAF1PSMD812319117353931 Affinity Capture-MS
PAAF1PSMD811168617353931 Affinity Capture-MS
PSMD6PSMD811519517353931 Affinity Capture-MS
PSMD6PSMD811168617353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1888669
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040625-136'