AutismKB 2.0

Annotation Details for RTN4


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Basic Information Top
Gene Symbol:RTN4 ( ASY,NI220/250,NOGO,NOGO-A,NOGOC,NSP,NSP-CL,Nbla00271,Nbla10545,Nogo-B,Nogo-C,RTN-X,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C )
Gene Full Name: reticulon 4
Band: 2p16.1
Quick LinksEntrez ID:57142; OMIM: 604475; Uniprot ID:RTN4_HUMAN; ENSEMBL ID: ENSG00000115310; HGNC ID: 14085
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IMP-intracellular14644040
GO:0005635IDA-nuclear envelope11126360
GO:0005783IDA-endoplasmic reticulum16791210
GO:0005783NAS-endoplasmic reticulum11126360
GO:0005789IDA-endoplasmic reticulum membrane25612671
GO:0005886TAS-plasma membrane-
GO:0014069IEA-postsynaptic density-
GO:0030176IDA-integral component of endoplasmic reticulum membrane10667797
GO:0042995IEA-cell projection-
GO:0070062IDA-extracellular exosome23376485
GO:0071782IDA-endoplasmic reticulum tubular network27353365
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005515IPI-protein binding11126360
GO:0031625IPI-ubiquitin protein ligase binding27353365
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0006915NAS-apoptotic process11126360
GO:0007413ISS-axonal fasciculation-
GO:0010634IMP-positive regulation of epithelial cell migration27353365
GO:0021801ISS-cerebral cortex radial glia guided migration-
GO:0030308IMP-negative regulation of cell growth20463223
GO:0030517IDA-negative regulation of axon extension10667797
GO:0033601IMP-positive regulation of mammary gland epithelial cell proliferation27353365
GO:0042981NAS-regulation of apoptotic process11126360
GO:0050771TAS-negative regulation of axonogenesis-
GO:0050821IMP-protein stabilization27353365
GO:0051292IMP-nuclear pore complex assembly26906412
GO:0051897IMP-positive regulation of protein kinase B signaling27353365
GO:0060317IEA-cardiac epithelial to mesenchymal transition-
GO:0071786IMP-endoplasmic reticulum tubular network organization18779370
GO:0071787IDA-endoplasmic reticulum tubular network formation24262037
GO:1905552IDA-positive regulation of protein localization to endoplasmic reticulum27353365
GO:1905580IMP-positive regulation of ERBB3 signaling pathway27353365
GO:2000172ISS-regulation of branching morphogenesis of a nerve-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RTN4BCL212140011126360 Affinity Capture-Western; Two-hybrid
RTN4BCL210706811126360 Affinity Capture-Western; Two-hybrid
RTN4BCL2L112140011126360 Affinity Capture-Western; Two-hybrid
RTN4BCL2L110707011126360 Affinity Capture-Western; Two-hybrid
RTN4CRMP112140016169070 Two-hybrid
RTN4CRMP110779016169070 Two-hybrid
RTN4KCNA110993914592966 Affinity Capture-Western
RTN4KCNA112140014592966 Affinity Capture-Western
RTN4KCNA210994014592966 Affinity Capture-Western
RTN4KCNA212140014592966 Affinity Capture-Western
RTN4LRCH411021416189514 Two-hybrid
RTN4LRCH412140016189514 Two-hybrid
RTN4LRPAP112140016169070 Two-hybrid
RTN4LRPAP111022116169070 Two-hybrid
RTN4UQCRC112140012067236 Affinity Capture-Western
RTN4UQCRC111323012067236 Affinity Capture-Western
RTN4UQCRC211323112067236 Affinity Capture-Western
RTN4UQCRC212140012067236 Affinity Capture-Western
RTN4CNTNAP112140014592966 Affinity Capture-Western
RTN4CNTNAP111407814592966 Affinity Capture-Western
RTN4NAPA12140016189514 Two-hybrid
RTN4NAPA11430516189514 Two-hybrid
RTN4RAB33A11476416189514 Two-hybrid
RTN4RAB33A12140016189514 Two-hybrid
RTN4FXR211489016189514 Two-hybrid
RTN4FXR212140016189514 Two-hybrid
RTN4COL4A3BP12140016189514 Two-hybrid
RTN4COL4A3BP11539616189514 Two-hybrid
RTN4RTN312140016189514 Two-hybrid
RTN4RTN311559816189514 Two-hybrid
RTN4WWP112140019035836 Affinity Capture-Western; Reconstituted Complex
RTN4WWP111624319035836 Affinity Capture-Western; Reconstituted Complex
RTN4SIRT211659317353931 Affinity Capture-MS
RTN4SIRT212140017353931 Affinity Capture-MS
RTN4SPG2111947416189514 Two-hybrid
RTN4SPG2112140016189514 Two-hybrid
RTN4PRR1312140016169070 Two-hybrid
RTN4PRR1311996516169070 Two-hybrid
RTN4IP1RTN412140012067236 Affinity Capture-Western
RTN4IP1RTN412427612067236 Affinity Capture-Western
PLEKHF2RTN412140016189514 Two-hybrid
PLEKHF2RTN412279116189514 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
RTN4BCL219737911126360 RTN-XS interacts with Bcl-2.
RTN4RRTN421007815694321 Nogo-66 interacts with NgR.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
RTN4RTN4_ins_CAA, RTN4_ins_TATC, rs10496037, rs1822617, rs1822618, rs2241958, rs2919129, rs2920898, rs2972090, rs6715980, rs7597198, rs7601625 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1915835
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030710-1'