AutismKB 2.0

Annotation Details for SMURF1


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Basic Information Top
Gene Symbol:SMURF1 ( KIAA1625 )
Gene Full Name: SMAD specific E3 ubiquitin protein ligase 1
Band: 7q22.1
Quick LinksEntrez ID:57154; OMIM: 605568; Uniprot ID:SMUF1_HUMAN; ENSEMBL ID: ENSG00000198742; HGNC ID: 16807
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm11278251
GO:0005739IGIcolocalizes_withmitochondrion22020285
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane12151385
GO:0030424IEA-axon-
GO:0043025IEA-neuronal cell body-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004842IDA-ubiquitin-protein transferase activity10458166
GO:0005515IPI-protein binding15231748
GO:0005543TAS-phospholipid binding22020285
GO:0048185NAS-activin binding16720724
GO:0061630IDA-ubiquitin protein ligase activity11278251
GO:0061630TAS-ubiquitin protein ligase activity-
GO:0070411IPI-I-SMAD binding11278251
GO:0070412IPI-R-SMAD binding11278251
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination19937093
GO:0006611IDA-protein export from nucleus11278251
GO:0007179TAS-transforming growth factor beta receptor signaling pathway-
GO:0007398TAS-ectoderm development10458166
GO:0016567IDA-protein ubiquitination11278251
GO:0030154IDA-cell differentiation10458166
GO:0030279IEA-negative regulation of ossification-
GO:0030509IDA-BMP signaling pathway21572392
GO:0030509TAS-BMP signaling pathway-
GO:0030512IDA-negative regulation of transforming growth factor beta receptor signaling pathway11278251
GO:0030514TAS-negative regulation of BMP signaling pathway10458166
GO:0030579IDA-ubiquitin-dependent SMAD protein catabolic process11278251
GO:0032801IDA-receptor catabolic process12151385
GO:0034394IDA-protein localization to cell surface12151385
GO:0042787IDA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process10458166
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process11278251
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0061734IEA-parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization-
GO:0061736IMP-engulfment of target by autophagosome22020285
GO:0061753IMP-substrate localization to autophagosome22020285
GO:0071211IMP-protein targeting to vacuole involved in autophagy22020285
GO:0072661TAS-protein targeting to plasma membrane22020285
GO:1903861IDA-positive regulation of dendrite extension23999003
GO:2000060IMP-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process21454619
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SMURF1ACVR1B12141116720724 Affinity Capture-Western
SMURF1ACVR1B10660616720724 Affinity Capture-Western
SMURF1RHOA12141116622418 Reconstituted Complex
SMURF1RHOA10688016622418 Reconstituted Complex
SMURF1RUNX312141115138260 Affinity Capture-Western
SMURF1RUNX310731215138260 Affinity Capture-Western
SMURF1SMAD111026115221015 16611643 Affinity Capture-Western; Biochemical Activity
SMURF1SMAD112141115221015 16611643 Affinity Capture-Western; Biochemical Activity
SMURF1SMAD212141115221015 Affinity Capture-Western
SMURF1SMAD211026215221015 Affinity Capture-Western
SMURF1SMAD312141115221015 Affinity Capture-Western
SMURF1SMAD311026315221015 Affinity Capture-Western
SMURF1SMAD412141115817471 Affinity Capture-Western
SMURF1SMAD411026415817471 Affinity Capture-Western
SMURF1SMAD512141115221015 18641638 Affinity Capture-Western
SMURF1SMAD511026515221015 18641638 Affinity Capture-Western
SMURF1SMAD611026615221015 Affinity Capture-Western
SMURF1SMAD612141115221015 Affinity Capture-Western
SMURF1SMAD712141114722617 15221015 16720724 Affinity Capture-Western
SMURF1SMAD711026714722617 15221015 16720724 Affinity Capture-Western
SMURF1TGFBR112141114657019 Affinity Capture-Western
SMURF1TGFBR111290414657019 Affinity Capture-Western
SMURF1TRAF212141119937093 Phenotypic Suppression
SMURF1TRAF211303819937093 Phenotypic Suppression
SMURF1TRAF312141119937093 Phenotypic Suppression
SMURF1TRAF311303919937093 Phenotypic Suppression
SMURF1TRAF511304019937093 Phenotypic Suppression
SMURF1TRAF512141119937093 Phenotypic Suppression
SMURF1TRAF612141119937093 Phenotypic Suppression
SMURF1TRAF611304119937093 Phenotypic Suppression
SMURF1UBC11316417894482 18641638 Affinity Capture-Western
SMURF1UBC12141117894482 18641638 Affinity Capture-Western
SMURF1PDLIM711468216611643 Affinity Capture-MS; Affinity Capture-Western; Protein-peptide
SMURF1PDLIM712141116611643 Affinity Capture-MS; Affinity Capture-Western; Protein-peptide
SMURF1TRAF411497919937093 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
SMURF1TRAF412141119937093 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
SMURF1ARHGEF912141118208356 Affinity Capture-Western; Reconstituted Complex
SMURF1ARHGEF911683418208356 Affinity Capture-Western; Reconstituted Complex
SMURF1PLEKHO111935518641638 Affinity Capture-Western; Reconstituted Complex
SMURF1PLEKHO112141118641638 Affinity Capture-Western; Reconstituted Complex
SMURF2SMURF112141118927080 Affinity Capture-Western
SMURF2SMURF112226518927080 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1923038
  • Data Attributes: HomoloGene calculated
No data