AutismKB 2.0

Annotation Details for PTEN


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Basic Information Top
Gene Symbol:PTEN ( 10q23del,BZS,DEC,GLM2,MGC11227,MHAM,MMAC1,PTEN1,TEP1 )
Gene Full Name: phosphatase and tensin homolog
Band: 10q23.31
Quick LinksEntrez ID:5728; OMIM: 601728; Uniprot ID:PTEN_HUMAN; ENSEMBL ID: ENSG00000171862; HGNC ID: 9588
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005634IDA-nucleus17218261
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm9187108
GO:0005737TAS-cytoplasm9367992
GO:0005739IEA-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane10760291
GO:0009898IDA-cytoplasmic side of plasma membrane10940933
GO:0016324IMP-apical plasma membrane24862762
GO:0016605IEA-PML body-
GO:0035749ISS-myelin sheath adaxonal region-
GO:0042995IDA-cell projection10760291
GO:0043005ISS-neuron projection-
GO:0043197IEA-dendritic spine-
GO:0043220ISS-Schmidt-Lanterman incisure-
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0000287IEA-magnesium ion binding-
GO:0004438IDA-phosphatidylinositol-3-phosphatase activity9811831
GO:0004721IDA-phosphoprotein phosphatase activity21241890
GO:0004722IDA-protein serine/threonine phosphatase activity9256433
GO:0004725IDA-protein tyrosine phosphatase activity9256433
GO:0005161IEA-platelet-derived growth factor receptor binding-
GO:0005515IPI-protein binding15355975
GO:0008138IEA-protein tyrosine/serine/threonine phosphatase activity-
GO:0008289IEA-lipid binding-
GO:0010997IPI-anaphase-promoting complex binding21241890
GO:0016314IDA-phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity9593664
GO:0016314TAS-phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity-
GO:0019899IPI-enzyme binding16845383
GO:0030165IPI-PDZ domain binding10646847
GO:0035255IEA-ionotropic glutamate receptor binding-
GO:0042802IPI-identical protein binding24766807
GO:0051717IDA-inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity9593664
GO:0051717TAS-inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity-
GO:0051800IDA-phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity9811831
GO:0051800TAS-phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity-
GO:1990381IPI-ubiquitin-specific protease binding26280536
GO:1990782IEA-protein tyrosine kinase binding-
GO ID Evidence Qualifier GO_term References
GO:0000079TAS-regulation of cyclin-dependent protein serine/threonine kinase activity10918569
GO:0001525IEA-angiogenesis-
GO:0001933IDA-negative regulation of protein phosphorylation20123964
GO:0001933ISS-negative regulation of protein phosphorylation-
GO:0002902IEA-regulation of B cell apoptotic process-
GO:0006470IDA-protein dephosphorylation9256433
GO:0006470TAS-protein dephosphorylation9367992
GO:0006661TAS-phosphatidylinositol biosynthetic process-
GO:0006915ISS-apoptotic process-
GO:0007270ISS-neuron-neuron synaptic transmission-
GO:0007416ISS-synapse assembly-
GO:0007417ISS-central nervous system development-
GO:0007507ISS-heart development-
GO:0007568IEA-aging-
GO:0007584IEA-response to nutrient-
GO:0007611ISS-learning or memory-
GO:0007613IEA-memory-
GO:0007626ISS-locomotory behavior-
GO:0008283TAS-cell proliferation10918569
GO:0008284ISS-positive regulation of cell proliferation-
GO:0008285IDA-negative regulation of cell proliferation19057511
GO:0008285IMP-negative regulation of cell proliferation10468583
GO:0009749IEA-response to glucose-
GO:0010043IEA-response to zinc ion-
GO:0010628IEA-positive regulation of gene expression-
GO:0010666IEA-positive regulation of cardiac muscle cell apoptotic process-
GO:0010719IMP-negative regulation of epithelial to mesenchymal transition27919618
GO:0010975ISS-regulation of neuron projection development-
GO:0014067NAS-negative regulation of phosphatidylinositol 3-kinase signaling16762633
GO:0014067TAS-negative regulation of phosphatidylinositol 3-kinase signaling18082964
GO:0014823IEA-response to activity-
GO:0016477ISS-cell migration-
GO:0016579TAS-protein deubiquitination-
GO:0021542ISS-dentate gyrus development-
GO:0021955ISS-central nervous system neuron axonogenesis-
GO:0030336IMP-negative regulation of cell migration9616126
GO:0030534IEA-adult behavior-
GO:0031642IEA-negative regulation of myelination-
GO:0031647IMP-regulation of protein stability10866658
GO:0031658IDA-negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle21241890
GO:0032228IEA-regulation of synaptic transmission, GABAergic-
GO:0032286ISS-central nervous system myelin maintenance-
GO:0032355IEA-response to estradiol-
GO:0032535ISS-regulation of cellular component size-
GO:0032869IEA-cellular response to insulin stimulus-
GO:0033032IEA-regulation of myeloid cell apoptotic process-
GO:0033198IEA-response to ATP-
GO:0033555ISS-multicellular organismal response to stress-
GO:0035176ISS-social behavior-
GO:0035335IEA-peptidyl-tyrosine dephosphorylation-
GO:0042493IEA-response to drug-
GO:0042711IEA-maternal behavior-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043491ISS-protein kinase B signaling-
GO:0043542IEA-endothelial cell migration-
GO:0043647TAS-inositol phosphate metabolic process-
GO:0044320IEA-cellular response to leptin stimulus-
GO:0045475ISS-locomotor rhythm-
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0045792ISS-negative regulation of cell size-
GO:0046621ISS-negative regulation of organ growth-
GO:0046685IEA-response to arsenic-containing substance-
GO:0046855IDA-inositol phosphate dephosphorylation9593664
GO:0046856IDA-phosphatidylinositol dephosphorylation9593664
GO:0046856IMP-phosphatidylinositol dephosphorylation21828076
GO:0048008IEA-platelet-derived growth factor receptor signaling pathway-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048681IEA-negative regulation of axon regeneration-
GO:0048738IEA-cardiac muscle tissue development-
GO:0048853ISS-forebrain morphogenesis-
GO:0048854ISS-brain morphogenesis-
GO:0050680IEA-negative regulation of epithelial cell proliferation-
GO:0050765IEA-negative regulation of phagocytosis-
GO:0050771ISS-negative regulation of axonogenesis-
GO:0050821IDA-protein stabilization20123964
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity20123964
GO:0051548IMP-negative regulation of keratinocyte migration27919618
GO:0051895IMP-negative regulation of focal adhesion assembly9616126
GO:0051898IMP-negative regulation of protein kinase B signaling10760291
GO:0060024ISS-rhythmic synaptic transmission-
GO:0060044IEA-negative regulation of cardiac muscle cell proliferation-
GO:0060070IDA-canonical Wnt signaling pathway20123964
GO:0060074ISS-synapse maturation-
GO:0060134ISS-prepulse inhibition-
GO:0060179IEA-male mating behavior-
GO:0060291IEA-long-term synaptic potentiation-
GO:0060292IEA-long term synaptic depression-
GO:0060736IEA-prostate gland growth-
GO:0060997ISS-dendritic spine morphogenesis-
GO:0061002ISS-negative regulation of dendritic spine morphogenesis-
GO:0070373IMP-negative regulation of ERK1 and ERK2 cascade19962668
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0071257IMP-cellular response to electrical stimulus27919618
GO:0071361IEA-cellular response to ethanol-
GO:0071456IEA-cellular response to hypoxia-
GO:0090071IEA-negative regulation of ribosome biogenesis-
GO:0090344IEA-negative regulation of cell aging-
GO:0090394ISS-negative regulation of excitatory postsynaptic potential-
GO:0097105ISS-presynaptic membrane assembly-
GO:0097107ISS-postsynaptic density assembly-
GO:1901017IEA-negative regulation of potassium ion transmembrane transporter activity-
GO:1903690IMP-negative regulation of wound healing, spreading of epidermal cells27919618
GO:1903984IMP-positive regulation of TRAIL-activated apoptotic signaling pathway19962668
GO:1904668IDA-positive regulation of ubiquitin protein ligase activity21241890
GO:1990090IEA-cellular response to nerve growth factor stimulus-
GO:1990314IEA-cellular response to insulin-like growth factor stimulus-
GO:2000060IDA-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process21241890
GO:2000134IDA-negative regulation of G1/S transition of mitotic cell cycle21241890
GO:2000272IEA-negative regulation of receptor activity-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
GO:2000808ISS-negative regulation of synaptic vesicle clustering-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PTENANG11170016169070 Two-hybrid
PTENANG10678016169070 Two-hybrid
PTENAR11170015205473 Affinity Capture-Western; Reconstituted Complex
PTENAR10686215205473 Affinity Capture-Western; Reconstituted Complex
PTENCAV110730512176037 Affinity Capture-Western
PTENCAV111170012176037 Affinity Capture-Western
PTENCHGB10753916169070 Two-hybrid
PTENCHGB11170016169070 Two-hybrid
PTENCSNK2A110784112297295 Biochemical Activity; Reconstituted Complex
PTENCSNK2A111170012297295 Biochemical Activity; Reconstituted Complex
PTENCSNK2A210784212297295 Biochemical Activity; Reconstituted Complex
PTENCSNK2A211170012297295 Biochemical Activity; Reconstituted Complex
PTENESR110840315205473 Reconstituted Complex
PTENESR111170015205473 Reconstituted Complex
PTENHBA110928916169070 Two-hybrid
PTENHBA111170016169070 Two-hybrid
PTENNEDD411170018498243 Biochemical Activity; Reconstituted Complex
PTENNEDD411081118498243 Biochemical Activity; Reconstituted Complex
PTK2PTEN11171910400703 11857088 Affinity Capture-Western
PTK2PTEN11170010400703 11857088 Affinity Capture-Western
MAGI3PTEN12927710748157 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAGI3PTEN11170010748157 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PXNPTEN11178711857088 Affinity Capture-Western
PXNPTEN11170011857088 Affinity Capture-Western
MVPPTEN11528612177006 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MVPPTEN11170012177006 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TP53PTEN11170012620407 Affinity Capture-Western
TP53PTEN11301012620407 Affinity Capture-Western
UBE2IPTEN11317712620973 Affinity Capture-Western
UBE2IPTEN11170012620973 Affinity Capture-Western
UBE2L3PTEN11318012620973 Affinity Capture-Western
UBE2L3PTEN11170012620973 Affinity Capture-Western
UBCPTEN11316412743124 18498243 Affinity Capture-Western; Reconstituted Complex
UBCPTEN11170012743124 18498243 Affinity Capture-Western; Reconstituted Complex
UTP14APTEN11602616169070 Two-hybrid
UTP14APTEN11170016169070 Two-hybrid
COPS6PTEN11617616169070 Two-hybrid
COPS6PTEN11170016169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PTENrs1234213, rs1234220, rs1234224, rs1799734, rs1903858, rs2299939, rs532678, rs555895, rs926091 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
PTENrs10490920, rs1234223, rs12357281, rs1903858, rs2299939, rs2673832 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109583
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3776'