AutismKB 2.0

Annotation Details for PTGS2


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Basic Information Top
Gene Symbol:PTGS2 ( COX-2,COX2,GRIPGHS,PGG/HS,PGHS-2,PHS-2,hCox-2 )
Gene Full Name: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Band: 1q31.1
Quick LinksEntrez ID:5743; OMIM: 600262; Uniprot ID:PGH2_HUMAN; ENSEMBL ID: ENSG00000073756; HGNC ID: 9605
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005737IDA-cytoplasm14511332
GO:0005737ISS-cytoplasm-
GO:0005783IDA-endoplasmic reticulum24089527
GO:0005788TAS-endoplasmic reticulum lumen24089527
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005901IEA-caveola-
GO:0031090IEA-organelle membrane-
GO:0043005IDA-neuron projection12355421
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0004601NAS-peroxidase activity14511332
GO:0004601TAS-peroxidase activity-
GO:0004666IDA-prostaglandin-endoperoxide synthase activity1380156
GO:0004666TAS-prostaglandin-endoperoxide synthase activity-
GO:0005515IPI-protein binding24089527
GO:0008289IEA-lipid binding-
GO:0019899IPI-enzyme binding16373578
GO:0020037ISS-heme binding-
GO:0042803IEA-protein homodimerization activity-
GO:0046872IEA-metal ion binding-
GO:0050473TAS-arachidonate 15-lipoxygenase activity-
GO ID Evidence Qualifier GO_term References
GO:0001516ISS-prostaglandin biosynthetic process-
GO:0001516NAS-prostaglandin biosynthetic process20448152
GO:0001525IEA-angiogenesis-
GO:0006693TAS-prostaglandin metabolic process9630216
GO:0006928TAS-movement of cell or subcellular component9630216
GO:0006954IEA-inflammatory response-
GO:0006979IEA-response to oxidative stress-
GO:0007566IEA-embryo implantation-
GO:0007568IEA-aging-
GO:0007612IEA-learning-
GO:0007613IEA-memory-
GO:0008217ISS-regulation of blood pressure-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0009750IEA-response to fructose-
GO:0010042IEA-response to manganese ion-
GO:0010226IEA-response to lithium ion-
GO:0010575ISS-positive regulation of vascular endothelial growth factor production9630216
GO:0019233IEA-sensory perception of pain-
GO:0019371IDA-cyclooxygenase pathway1380156
GO:0019371TAS-cyclooxygenase pathway-
GO:0019372TAS-lipoxygenase pathway-
GO:0030282IEA-bone mineralization-
GO:0030728IEA-ovulation-
GO:0031394NAS-positive regulation of prostaglandin biosynthetic process20448152
GO:0031622ISS-positive regulation of fever generation-
GO:0031915IEA-positive regulation of synaptic plasticity-
GO:0032227IEA-negative regulation of synaptic transmission, dopaminergic-
GO:0032355IEA-response to estradiol-
GO:0032496IEA-response to lipopolysaccharide-
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0033280IEA-response to vitamin D-
GO:0034356TAS-NAD biosynthesis via nicotinamide riboside salvage pathway-
GO:0034605IEA-cellular response to heat-
GO:0034612IEA-response to tumor necrosis factor-
GO:0034644IEA-cellular response to UV-
GO:0035633IEA-maintenance of permeability of blood-brain barrier-
GO:0042346IEA-positive regulation of NF-kappaB import into nucleus-
GO:0042493IEA-response to drug-
GO:0042633IEA-hair cycle-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043154IEA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0045429ISS-positive regulation of nitric oxide biosynthetic process9630216
GO:0045786IEA-negative regulation of cell cycle-
GO:0045907IEA-positive regulation of vasoconstriction-
GO:0045986IEA-negative regulation of smooth muscle contraction-
GO:0045987IEA-positive regulation of smooth muscle contraction-
GO:0046697IEA-decidualization-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0050727NAS-regulation of inflammatory response14511332
GO:0050873IEA-brown fat cell differentiation-
GO:0051384IEA-response to glucocorticoid-
GO:0051926IEA-negative regulation of calcium ion transport-
GO:0051968IEA-positive regulation of synaptic transmission, glutamatergic-
GO:0055114IEA-oxidation-reduction process-
GO:0070542IEA-response to fatty acid-
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071318IEA-cellular response to ATP-
GO:0071456IEP-cellular response to hypoxia21296955
GO:0071471IEA-cellular response to non-ionic osmotic stress-
GO:0071498IEA-cellular response to fluid shear stress-
GO:0071636ISS-positive regulation of transforming growth factor beta production9630216
GO:0090050ISS-positive regulation of cell migration involved in sprouting angiogenesis9630216
GO:0090271ISS-positive regulation of fibroblast growth factor production9630216
GO:0090336ISS-positive regulation of brown fat cell differentiation20448152
GO:0090362ISS-positive regulation of platelet-derived growth factor production-
GO:0098869IEA-cellular oxidant detoxification-
GO:1902219IEA-negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PTGS2CAV110730511432874 Affinity Capture-Western; Reconstituted Complex
PTGS2CAV111171511432874 Affinity Capture-Western; Reconstituted Complex
PTGS2NUCB11109788643612 Two-hybrid
PTGS2NUCB11117158643612 Two-hybrid
PTGS2PSMC511171517429597 Affinity Capture-Western
PTGS2PSMC511167817429597 Affinity Capture-Western
PTGS2PSMD111171517429597 Affinity Capture-Western
PTGS2PSMD111168017429597 Affinity Capture-Western
TP53PTGS211171511687965 Affinity Capture-Western
TP53PTGS211301011687965 Affinity Capture-Western
COPS7APTGS211913017429597 Affinity Capture-Western
COPS7APTGS211171517429597 Affinity Capture-Western
CUL4APTGS211402917429597 Affinity Capture-Western
CUL4APTGS211171517429597 Affinity Capture-Western
CUL1PTGS211403217429597 Affinity Capture-Western
CUL1PTGS211171517429597 Affinity Capture-Western
COPS3PTGS211171517429597 Affinity Capture-Western
COPS3PTGS211410317429597 Affinity Capture-Western
RBX1PTGS211530117429597 Affinity Capture-Western
RBX1PTGS211171517429597 Affinity Capture-Western
COPS5PTGS211618317429597 Affinity Capture-Western; Co-fractionation
COPS5PTGS211171517429597 Affinity Capture-Western; Co-fractionation
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PTGS2rs12042763, rs20417, rs20432, rs2143417, rs5275, rs689466 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
PTGS2rs20417, rs5275, rs5277, rs689466 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
PTGS2PTGS2_SNP1, PTGS2_SNP2, PTGS2_SNP3, rs2745557 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97798
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020530-2'