AutismKB 2.0

Annotation Details for NLGN4X


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Basic Information Top
Gene Symbol:NLGN4X ( ASPGX2,AUTSX2,HLNX,HNLX,KIAA1260,MGC22376,NLGN,NLGN4 )
Gene Full Name: neuroligin 4, X-linked
Band: Xp22.32-p22.31
Quick LinksEntrez ID:57502; OMIM: 300427; Uniprot ID:NLGNX_HUMAN; ENSEMBL ID: ENSG00000146938; HGNC ID: 14287
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane19726642
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane11368788
GO:0009986IDA-cell surface15150161
GO:0014069IEA-postsynaptic density-
GO:0016021NAS-integral component of membrane16377159
GO:0030054IEA-cell junction-
GO:0030425IDA-dendrite19726642
GO:0045202ISS-synapse18227507
GO:0045211IEA-postsynaptic membrane-
GO:0060076IDA-excitatory synapse15620359
GO ID Evidence Qualifier GO_term References
GO:0004872IBA-receptor activity-
GO:0005515IPI-protein binding11368788
GO:0031404IDA-chloride ion binding18093521
GO:0042043IDA-neurexin family protein binding19726642
GO:0042043IPI-neurexin family protein binding18093521
GO:0042803IDA-protein homodimerization activity18093521
GO:0050839TAS-cell adhesion molecule binding18923512
GO:0052689IBA-carboxylic ester hydrolase activity-
GO:0097110IPI-scaffold protein binding11368788
GO ID Evidence Qualifier GO_term References
GO:0003360ISS-brainstem development18227507
GO:0007158TAS-neuron cell-cell adhesion18923512
GO:0007612IMP-learning12669065
GO:0021549ISS-cerebellum development18227507
GO:0030182NAS-neuron differentiation21278334
GO:0030534IMP-adult behavior12669065
GO:0035176IMP-social behavior12669065
GO:0035265ISS-organ growth18227507
GO:0045216NAS-cell-cell junction organization11368788
GO:0050808IMP-synapse organization15150161
GO:0050808NAS-synapse organization11368788
GO:0071625IMP-vocalization behavior12669065
GO:0071625ISS-vocalization behavior18227507
GO:0090394IDA-negative regulation of excitatory postsynaptic potential19726642
GO:0097105IDA-presynaptic membrane assembly19726642
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLGN4XDLG412156711368788 Affinity Capture-Western
NLGN4XDLG410808611368788 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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