Gene Symbol:	RPTOR ( KIAA1303,KOG1,Mip1 )
Gene Full Name:	regulatory associated protein of MTOR, complex 1
Band:	17q25.3
Quick Links	Entrez ID:57521; OMIM: 607130; Uniprot ID:RPTOR_HUMAN; ENSEMBL ID: ENSG00000141564; HGNC ID: 30287
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005654	IDA	-	nucleoplasm	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	20381137
GO:0005764	IDA	-	lysosome	20381137
GO:0005764	IMP	-	lysosome	22424946
GO:0005765	IDA	-	lysosomal membrane	17897319
GO:0005829	IDA	-	cytosol	-
GO:0005829	TAS	-	cytosol	-
GO:0010494	IDA	-	cytoplasmic stress granule	25940091
GO:0030425	IEA	-	dendrite	-
GO:0031931	IDA	-	TORC1 complex	12150926
GO:0043025	IEA	-	neuronal cell body	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001030	IDA	-	RNA polymerase III type 1 promoter DNA binding	20233713
GO:0001031	IDA	-	RNA polymerase III type 2 promoter DNA binding	20233713
GO:0001032	IDA	-	RNA polymerase III type 3 promoter DNA binding	20233713
GO:0001156	IDA	-	TFIIIC-class transcription factor binding	20543138
GO:0005515	IPI	-	protein binding	12150925
GO:0019901	IPI	-	protein kinase binding	18439900
GO:0030291	IDA	-	protein serine/threonine kinase inhibitor activity	12718876
GO:0030295	IDA	-	protein kinase activator activity	12150926
GO:0030674	IDA	-	protein binding, bridging	12150926
GO:0032403	IPI	-	protein complex binding	19211835
GO:0071889	IDA	-	14-3-3 protein binding	18439900

GO ID	Evidence	Qualifier	GO_term	References
GO:0001938	IEA	-	positive regulation of endothelial cell proliferation	-
GO:0007050	TAS	-	cell cycle arrest	-
GO:0008361	IMP	-	regulation of cell size	12150925
GO:0009267	IBA	-	cellular response to starvation	-
GO:0010506	IBA	-	regulation of autophagy	-
GO:0010800	IMP	-	positive regulation of peptidyl-threonine phosphorylation	18426977
GO:0016049	IMP	-	cell growth	20381137
GO:0016241	TAS	-	regulation of macroautophagy	-
GO:0030307	IMP	-	positive regulation of cell growth	18426977
GO:0031669	IMP	-	cellular response to nutrient levels	12150925
GO:0031929	IDA	-	TOR signaling	20381137
GO:0032008	IDA	-	positive regulation of TOR signaling	12150926
GO:0032147	IEA	-	activation of protein kinase activity	-
GO:0033138	IMP	-	positive regulation of peptidyl-serine phosphorylation	18426977
GO:0038202	IMP	-	TORC1 signaling	12718876
GO:0045945	IMP	-	positive regulation of transcription from RNA polymerase III promoter	20233713
GO:0071230	IMP	-	cellular response to amino acid stimulus	20381137
GO:0071233	IDA	-	cellular response to leucine	22424946
GO:0071901	IEA	-	negative regulation of protein serine/threonine kinase activity	-
GO:0071902	IDA	-	positive regulation of protein serine/threonine kinase activity	12150926
GO:1900034	TAS	-	regulation of cellular response to heat	-
GO:1900087	IMP	-	positive regulation of G1/S transition of mitotic cell cycle	18426977

Gene Symbol	Interactant	Interaction ID	References	Description
RPTOR	EIF4EBP1	121582	12150926 12604610 12747827 12912989 15767663 16798736 16824195 16837165	Affinity Capture-Western; Reconstituted Complex
RPTOR	EIF4EBP1	108293	12150926 12604610 12747827 12912989 15767663 16798736 16824195 16837165	Affinity Capture-Western; Reconstituted Complex
RPTOR	FKBP1A	108570	15268862 15467718	Affinity Capture-Western
RPTOR	FKBP1A	121582	15268862 15467718	Affinity Capture-Western
RPTOR	MTOR	108757	12150925 12150926 12604610 12665511 12719976 12747827 15066126 15268862 15459249 15467718 16183647 16354680 16603397 16631613 16798736 16837165 16847060 16919458 16962653 17043309 20427287	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPTOR	MTOR	121582	12150925 12150926 12604610 12665511 12719976 12747827 15066126 15268862 15459249 15467718 16183647 16354680 16603397 16631613 16798736 16837165 16847060 16919458 16962653 17043309 20427287	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPTOR	GDI2P1	121582	16354680	Affinity Capture-Western
RPTOR	GDI2P1	108935	16354680	Affinity Capture-Western
RPTOR	PDK1	111189	12150926	Affinity Capture-Western
RPTOR	PDK1	121582	12150926	Affinity Capture-Western
RPTOR	PLD2	121582	16837165	Affinity Capture-Western
RPTOR	PLD2	111354	16837165	Affinity Capture-Western
RPTOR	RHEB	111941	15854902	Affinity Capture-Western; Reconstituted Complex
RPTOR	RHEB	121582	15854902	Affinity Capture-Western; Reconstituted Complex
RPTOR	RPS6KB1	121582	12150926 12604610 15809305 16837165	Affinity Capture-Western; Reconstituted Complex
RPTOR	RPS6KB1	112112	12150926 12604610 15809305 16837165	Affinity Capture-Western; Reconstituted Complex
RPTOR	EIF3B	114211	16286006	Affinity Capture-Western
RPTOR	EIF3B	121582	16286006	Affinity Capture-Western
RPTOR	EIF3C	114212	16286006	Affinity Capture-Western
RPTOR	EIF3C	121582	16286006	Affinity Capture-Western
RICTOR	RPTOR	121582	16962653	Affinity Capture-MS
RICTOR	RPTOR	128962	16962653	Affinity Capture-MS
MAPKAP1	RPTOR	121582	16962653	Affinity Capture-MS
MAPKAP1	RPTOR	122551	16962653	Affinity Capture-MS
MLST8	RPTOR	121582	20562859	Affinity Capture-MS
MLST8	RPTOR	122113	20562859	Affinity Capture-MS

AutismKB 2.0

Annotation Details for RPTOR