AutismKB 2.0

Annotation Details for NLGN2


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Basic Information Top
Gene Symbol:NLGN2 ( KIAA1366 )
Gene Full Name: neuroligin 2
Band: 17p13.1
Quick LinksEntrez ID:57555; OMIM: 606479; Uniprot ID:NLGN2_HUMAN; ENSEMBL ID: ENSG00000169992; HGNC ID: 14290
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0009986IBA-cell surface-
GO:0009986ISS-cell surface-
GO:0016020NAS-membrane10892652
GO:0030054IEA-cell junction-
GO:0042734IEA-presynaptic membrane-
GO:0045202IBA-synapse-
GO:0045202ISS-synapse-
GO:0045211NAS-postsynaptic membrane10892652
GO:0060077ISS-inhibitory synapse-
GO:0099055ISS-integral component of postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004872IBA-receptor activity-
GO:0042043IBA-neurexin family protein binding-
GO:0042043ISS-neurexin family protein binding-
GO:0042043NAS-neurexin family protein binding10892652
GO:0050839ISS-cell adhesion molecule binding-
GO:0052689IBA-carboxylic ester hydrolase activity-
GO ID Evidence Qualifier GO_term References
GO:0002087ISS-regulation of respiratory gaseous exchange by neurological system process-
GO:0007158IBA-neuron cell-cell adhesion-
GO:0007158ISS-neuron cell-cell adhesion-
GO:0007416IBA-synapse assembly-
GO:0007416ISS-synapse assembly-
GO:0007416NAS-synapse assembly10892652
GO:0016337NAS-single organismal cell-cell adhesion10892652
GO:0019233IEA-sensory perception of pain-
GO:0032024IMP-positive regulation of insulin secretion22528485
GO:0032230ISS-positive regulation of synaptic transmission, GABAergic-
GO:0035418ISS-protein localization to synapse-
GO:0035641IEA-locomotory exploration behavior-
GO:0045217NAS-cell-cell junction maintenance10892652
GO:0050804IBA-modulation of synaptic transmission-
GO:0050804ISS-modulation of synaptic transmission-
GO:0050808ISS-synapse organization-
GO:0050885IEA-neuromuscular process controlling balance-
GO:0051965ISS-positive regulation of synapse assembly-
GO:0051968ISS-positive regulation of synaptic transmission, glutamatergic-
GO:0072553ISS-terminal button organization-
GO:0097104ISS-postsynaptic membrane assembly-
GO:0097105ISS-presynaptic membrane assembly-
GO:0097116ISS-gephyrin clustering involved in postsynaptic density assembly-
GO:0097119ISS-postsynaptic density protein 95 clustering-
GO:0097151ISS-positive regulation of inhibitory postsynaptic potential-
GO:1902474IDA-positive regulation of protein localization to synapse24613359
GO:1904862IEA-inhibitory synapse assembly-
GO:2000311ISS-regulation of AMPA receptor activity-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
GO:2000809IEA-positive regulation of synaptic vesicle clustering-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLGN2DLG21080849278515 Two-hybrid
NLGN2DLG21216119278515 Two-hybrid
NLGN2DLG31216119278515 Two-hybrid
NLGN2DLG31080859278515 Two-hybrid
NLGN2DLG41216119278515 Two-hybrid
NLGN2DLG41080869278515 Two-hybrid
NLGN2NRXN31147708576240 Reconstituted Complex
NLGN2NRXN31216118576240 Reconstituted Complex
NLGN2NRXN11216118576240 Reconstituted Complex
NLGN2NRXN11147798576240 Reconstituted Complex
NLGN2NRXN21216118576240 Reconstituted Complex
NLGN2NRXN21147808576240 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2681835
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090918-2'