AutismKB 2.0

Annotation Details for ALS2


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Basic Information Top
Gene Symbol:ALS2 ( ALS2CR6,ALSJ,FLJ31851,IAHSP,KIAA1563,MGC87187,PLSJ )
Gene Full Name: amyotrophic lateral sclerosis 2 (juvenile)
Band: 2q33.1
Quick LinksEntrez ID:57679; OMIM: 606352; Uniprot ID:ALS2_HUMAN; ENSEMBL ID: ENSG00000003393; HGNC ID: 443
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726ISS-ruffle-
GO:0005769IDA-early endosome12837691
GO:0005813IDA-centrosome16085057
GO:0005829IDA-cytosol12837691
GO:0005829TAS-cytosol-
GO:0014069IEA-postsynaptic density-
GO:0016020IEA-membrane-
GO:0030027ISS-lamellipodium-
GO:0030424IEA-axon-
GO:0030425IDA-dendrite15371724
GO:0030426ISS-growth cone-
GO:0031982IDA-vesicle12837691
GO:0043025IEA-neuronal cell body-
GO:0043197IEA-dendritic spine-
GO:0043231IEA-intracellular membrane-bounded organelle-
GO:0043234IDA-protein complex15247254
GO ID Evidence Qualifier GO_term References
GO:0005085IDAcontributes_toguanyl-nucleotide exchange factor activity15247254
GO:0005515IPI-protein binding21300063
GO:0017112IDA-Rab guanyl-nucleotide exchange factor activity12837691
GO:0017112TAS-Rab guanyl-nucleotide exchange factor activity-
GO:0017137IDA-Rab GTPase binding15247254
GO:0017137NAS-Rab GTPase binding16670179
GO:0030676IDA-Rac guanyl-nucleotide exchange factor activity16049005
GO:0042803IPI-protein homodimerization activity15247254
GO:0043539IDA-protein serine/threonine kinase activator activity16049005
GO ID Evidence Qualifier GO_term References
GO:0001662IEA-behavioral fear response-
GO:0001701IEA-in utero embryonic development-
GO:0001881IEA-receptor recycling-
GO:0006979IEA-response to oxidative stress-
GO:0007032IGI-endosome organization17239822
GO:0007032NAS-endosome organization12837691
GO:0007409IEA-axonogenesis-
GO:0007528IEA-neuromuscular junction development-
GO:0007626IEA-locomotory behavior-
GO:0008104IEA-protein localization-
GO:0008219IEA-cell death-
GO:0016197IEA-endosomal transport-
GO:0016601IEA-Rac protein signal transduction-
GO:0035022IC-positive regulation of Rac protein signal transduction16049005
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0035249IEA-synaptic transmission, glutamatergic-
GO:0043547IDA-positive regulation of GTPase activity16049005
GO:0045860IDA-positive regulation of protein kinase activity16049005
GO:0048812IDA-neuron projection morphogenesis16049005
GO:0051036IEP-regulation of endosome size15247254
GO:0061024TAS-membrane organization-
GO:0071902IEA-positive regulation of protein serine/threonine kinase activity-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1921268
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070402-2'