AutismKB 2.0

Annotation Details for CHD8


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Basic Information Top
Gene Symbol:CHD8 ( DKFZp686N17164,HELSNF1,KIAA1564 )
Gene Full Name: chromodomain helicase DNA binding protein 8
Band: 14q11.2
Quick LinksEntrez ID:57680; OMIM: 610528; Uniprot ID:CHD8_HUMAN; ENSEMBL ID: ENSG00000100888; HGNC ID: 20153
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus18378692
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0043234IDA-protein complex18378692
GO:0071339IDA-MLL1 complex15960975
GO ID Evidence Qualifier GO_term References
GO:0002039ISS-p53 binding-
GO:0003677IMP-DNA binding18378692
GO:0003678IMP-DNA helicase activity18378692
GO:0003682IDA-chromatin binding22083958
GO:0005515IPI-protein binding15960975
GO:0005524IDA-ATP binding18378692
GO:0008013IDA-beta-catenin binding18378692
GO:0008094IDA-DNA-dependent ATPase activity18378692
GO:0035064IDA-methylated histone binding17938208
GO:0042393ISS-histone binding-
GO:0070016IEA-armadillo repeat domain binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter25294932
GO:0001701IEA-in utero embryonic development-
GO:0006351IEA-transcription, DNA-templated-
GO:0007420IMP-brain development24998929
GO:0016569IEA-covalent chromatin modification-
GO:0030178IDA-negative regulation of Wnt signaling pathway18378692
GO:0032508IEA-DNA duplex unwinding-
GO:0043044IMP-ATP-dependent chromatin remodeling18378692
GO:0045892IMP-negative regulation of transcription, DNA-templated18378692
GO:0045893IDA-positive regulation of transcription, DNA-templated17938208
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter17938208
GO:0045945IMP-positive regulation of transcription from RNA polymerase III promoter17938208
GO:0048565IMP-digestive tract development24998929
GO:0060070IDA-canonical Wnt signaling pathway18378692
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway22083958
GO:2000270IEA-negative regulation of fibroblast apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CHD8CASR12170919151705 Affinity Capture-Western
CHD8CASR10729619151705 Affinity Capture-Western
CHD8CREB112170920936779 Two-hybrid
CHD8CREB110777520936779 Two-hybrid
CHD8CTNNB112170918378692 Affinity Capture-Western; Reconstituted Complex
CHD8CTNNB110788018378692 Affinity Capture-Western; Reconstituted Complex
CHD8RBBP512170920085832 Reconstituted Complex
CHD8RBBP511186420085832 Reconstituted Complex
CHD8TP5312170919151705 Affinity Capture-Western
CHD8TP5311301019151705 Affinity Capture-Western
CHD8USF112170917846119 Affinity Capture-MS
CHD8USF111323717846119 Affinity Capture-MS
CHD8ZNF14312170917938208 Affinity Capture-Western
CHD8ZNF14311349617938208 Affinity Capture-Western
CHD8TOP3B12170911549288 Two-hybrid
CHD8TOP3B11445211549288 Two-hybrid
CHD8ASH2L12170920085832 Co-localization; Reconstituted Complex
CHD8ASH2L11452820085832 Co-localization; Reconstituted Complex
CHD8CTDP112170919255092 Affinity Capture-Western
CHD8CTDP111459719255092 Affinity Capture-Western
CHD8CTCF12170916949368 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CHD8CTCF11590616949368 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CHD8TCERG112170915456888 Affinity Capture-MS
CHD8TCERG111612015456888 Affinity Capture-MS
CHD8WDR512170918378692 20085832 Affinity Capture-Western; Reconstituted Complex
CHD8WDR511627218378692 20085832 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1915022
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-6320'