AutismKB 2.0

Annotation Details for PTPN1


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Basic Information Top
Gene Symbol:PTPN1 ( PTP1B )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 1
Band: 20q13.13
Quick LinksEntrez ID:5770; OMIM: 176885; Uniprot ID:PTN1_HUMAN; ENSEMBL ID: ENSG00000196396; HGNC ID: 9642
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005769IDA-early endosome21135139
GO:0005783IDA-endoplasmic reticulum-
GO:0005829TAS-cytosol-
GO:0005886IDAcolocalizes_withplasma membrane21135139
GO:0097443ISS-sorting endosome-
GO:0098554IDA-cytoplasmic side of endoplasmic reticulum membrane1739967
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0004725IDA-protein tyrosine phosphatase activity18074158
GO:0004725TAS-protein tyrosine phosphatase activity-
GO:0005158IEA-insulin receptor binding-
GO:0005515IPI-protein binding8702689
GO:0008270IDA-zinc ion binding18074158
GO:0019899IPI-enzyme binding22169477
GO:0019901IPI-protein kinase binding22169477
GO:0030971IPI-receptor tyrosine kinase binding18819921
GO:0045296IDA-cadherin binding25468996
GO:0046875IPI-ephrin receptor binding21135139
GO:0051721IEA-protein phosphatase 2A binding-
GO ID Evidence Qualifier GO_term References
GO:0006470IMP-protein dephosphorylation22045810
GO:0006987TAS-activation of signaling protein activity involved in unfolded protein response22013210
GO:0007257IEA-activation of JUN kinase activity-
GO:0008286IEA-insulin receptor signaling pathway-
GO:0009966IMP-regulation of signal transduction21135139
GO:0009968TAS-negative regulation of signal transduction-
GO:0030100IDA-regulation of endocytosis21135139
GO:0030948ISS-negative regulation of vascular endothelial growth factor receptor signaling pathway-
GO:0030968IDA-endoplasmic reticulum unfolded protein response22169477
GO:0031532IMP-actin cytoskeleton reorganization21135139
GO:0033157IMP-regulation of intracellular protein transport22045810
GO:0035335IDA-peptidyl-tyrosine dephosphorylation21135139
GO:0035335IMP-peptidyl-tyrosine dephosphorylation14966296
GO:0035791IMP-platelet-derived growth factor receptor-beta signaling pathway14966296
GO:0036498IEA-IRE1-mediated unfolded protein response-
GO:0043407IMP-negative regulation of MAP kinase activity22045810
GO:0046627NAS-negative regulation of insulin receptor signaling pathway11742412
GO:0060338TAS-regulation of type I interferon-mediated signaling pathway-
GO:0060397TAS-JAK-STAT cascade involved in growth hormone signaling pathway-
GO:0061098IDA-positive regulation of protein tyrosine kinase activity21216966
GO:0070373ISS-negative regulation of ERK1 and ERK2 cascade-
GO:1902202IMP-regulation of hepatocyte growth factor receptor signaling pathway18819921
GO:1902236IEA-negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-
GO:1903896TAS-positive regulation of IRE1-mediated unfolded protein response22013210
GO:1903898IDA-negative regulation of PERK-mediated unfolded protein response21216966
GO:1990264ISS-peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity-
GO:2000646IMP-positive regulation of receptor catabolic process22045810
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PTPN1CAV110730512176037 Affinity Capture-Western
PTPN1CAV111173612176037 Affinity Capture-Western
PTPN1CRK1077888940134 Reconstituted Complex
PTPN1CRK1117368940134 Reconstituted Complex
PTPN1CTNNB110788012377785 Reconstituted Complex
PTPN1CTNNB111173612377785 Reconstituted Complex
PTPN1EGFR1117368621392 10889023 Biochemical Activity; Co-crystal Structure
PTPN1EGFR1082768621392 10889023 Biochemical Activity; Co-crystal Structure
PTPN1GHR10895712907755 Far Western; Reconstituted Complex
PTPN1GHR11173612907755 Far Western; Reconstituted Complex
PTPN1GRB21091428940134 10660596 Reconstituted Complex
PTPN1GRB21117368940134 10660596 Reconstituted Complex
PTPN1GSK3B1091877514173 Biochemical Activity
PTPN1GSK3B1117367514173 Biochemical Activity
PTPN1IGF1R1097018999839 Affinity Capture-Western
PTPN1IGF1R1117368999839 Affinity Capture-Western
PTPN1INSR10985411726652 Affinity Capture-Western
PTPN1INSR11173611726652 Affinity Capture-Western
PTPN1IRS111173610660596 11579209 Affinity Capture-Western; Reconstituted Complex
PTPN1IRS110987410660596 11579209 Affinity Capture-Western; Reconstituted Complex
PTPN1JAK210992011694501 Affinity Capture-Western
PTPN1JAK211173611694501 Affinity Capture-Western
PTPN1LTK11173612237455 Protein-peptide
PTPN1LTK11023612237455 Protein-peptide
PTPN1NTRK111096912237455 Protein-peptide
PTPN1NTRK111173612237455 Protein-peptide
PTPN1NTRK211097012237455 Protein-peptide
PTPN1NTRK211173612237455 Protein-peptide
PTPN1NTRK311097112237455 Protein-peptide
PTPN1NTRK311173612237455 Protein-peptide
BCAR1PTPN11117368940134 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BCAR1PTPN11149348940134 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
TYK2PTPN111173611694501 Affinity Capture-Western
TYK2PTPN111314811694501 Affinity Capture-Western
STAT5APTPN111265312237455 Protein-peptide
STAT5APTPN111173612237455 Protein-peptide
STAT5BPTPN111265412237455 Protein-peptide
STAT5BPTPN111173612237455 Protein-peptide
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97805
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980605-23'