AutismKB 2.0

Annotation Details for PTPN11


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Basic Information Top
Gene Symbol:PTPN11 ( BPTP3,CFC,MGC14433,NS1,PTP-1D,PTP2C,SH-PTP2,SH-PTP3,SHP2 )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 11
Band: 12q24.13
Quick LinksEntrez ID:5781; OMIM: 176876; Uniprot ID:PTN11_HUMAN; ENSEMBL ID: ENSG00000179295; HGNC ID: 9644
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus15133037
GO:0005737IDA-cytoplasm10940933
GO:0005739IEA-mitochondrion-
GO:0005829TAS-cytosol-
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0004721IDA-phosphoprotein phosphatase activity15133037
GO:0004725IDA-protein tyrosine phosphatase activity15133037
GO:0004725TAS-protein tyrosine phosphatase activity-
GO:0004726IMP-non-membrane spanning protein tyrosine phosphatase activity10655584
GO:0004726TAS-non-membrane spanning protein tyrosine phosphatase activity-
GO:0005070IPI-SH3/SH2 adaptor activity7493946
GO:0005158IPI-insulin receptor binding7493946
GO:0005515IPI-protein binding7493946
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0019904IEA-protein domain specific binding-
GO:0030971IEA-receptor tyrosine kinase binding-
GO:0031748IEA-D1 dopamine receptor binding-
GO:0043274IEA-phospholipase binding-
GO:0043560IEA-insulin receptor substrate binding-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0050839IEA-cell adhesion molecule binding-
GO:0051428IEA-peptide hormone receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0000077IEA-DNA damage checkpoint-
GO:0000187IEA-activation of MAPK activity-
GO:0006641IEA-triglyceride metabolic process-
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0007411TAS-axon guidance-
GO:0007420IMP-brain development11704759
GO:0007507IMP-heart development12058348
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0009755IEA-hormone-mediated signaling pathway-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0021697IEA-cerebellar cortex formation-
GO:0030168TAS-platelet activation-
GO:0030220IEA-platelet formation-
GO:0031295TAS-T cell costimulation-
GO:0032528IEA-microvillus organization-
GO:0033277IEA-abortive mitotic cell cycle-
GO:0033628IMP-regulation of cell adhesion mediated by integrin10655584
GO:0033629IEA-negative regulation of cell adhesion mediated by integrin-
GO:0035264IEA-multicellular organism growth-
GO:0035265IEA-organ growth-
GO:0035335IDA-peptidyl-tyrosine dephosphorylation15133037
GO:0035335IMP-peptidyl-tyrosine dephosphorylation10655584
GO:0035855IEA-megakaryocyte development-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0036302IMP-atrioventricular canal development12058348
GO:0038127IDA-ERBB signaling pathway15133037
GO:0040014IEA-regulation of multicellular organism growth-
GO:0042445IEA-hormone metabolic process-
GO:0042593IEA-glucose homeostasis-
GO:0043254IDA-regulation of protein complex assembly7493946
GO:0045931IEA-positive regulation of mitotic cell cycle-
GO:0046676IEA-negative regulation of insulin secretion-
GO:0046825IEA-regulation of protein export from nucleus-
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0046887IEA-positive regulation of hormone secretion-
GO:0048008IEA-platelet-derived growth factor receptor signaling pathway-
GO:0048011IEA-neurotrophin TRK receptor signaling pathway-
GO:0048013IDA-ephrin receptor signaling pathway10655584
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048609IEA-multicellular organismal reproductive process-
GO:0048806IMP-genitalia development12058348
GO:0048839IMP-inner ear development12058348
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0050900TAS-leukocyte migration-
GO:0051463IEA-negative regulation of cortisol secretion-
GO:0060020IEA-Bergmann glial cell differentiation-
GO:0060125IEA-negative regulation of growth hormone secretion-
GO:0060325IMP-face morphogenesis11704759
GO:0060338TAS-regulation of type I interferon-mediated signaling pathway-
GO:0061582IEA-intestinal epithelial cell migration-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade28074573
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071364IMP-cellular response to epidermal growth factor stimulus28074573
GO:2001275IDA-positive regulation of glucose import in response to insulin stimulus7493946
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PTPN11CEACAM11117459867848 Affinity Capture-Western; Reconstituted Complex
PTPN11CEACAM11071039867848 Affinity Capture-Western; Reconstituted Complex
PTPN11CAV111174512176037 Affinity Capture-Western
PTPN11CAV110730512176037 Affinity Capture-Western
PTPN11CBL11174518519587 Affinity Capture-Western
PTPN11CBL10731518519587 Affinity Capture-Western
PTPN11CD3311174510206955 Affinity Capture-Western; Reconstituted Complex
PTPN11CD3310738310206955 Affinity Capture-Western; Reconstituted Complex
PTPN11CDH511174510681592 Affinity Capture-Western
PTPN11CDH510743810681592 Affinity Capture-Western
PTPN11CRKL1117459344843 Affinity Capture-Western
PTPN11CRKL1077899344843 Affinity Capture-Western
PTPN11CSF2RB1078269162089 Affinity Capture-Western; Reconstituted Complex
PTPN11CSF2RB1117459162089 Affinity Capture-Western; Reconstituted Complex
PTPN11CSF3R1078289824671 Far Western
PTPN11CSF3R1117459824671 Far Western
PTPN11CTNNB111174510681592 Affinity Capture-Western
PTPN11CTNNB110788010681592 Affinity Capture-Western
PTPN11EGFR1117457673163 16729043 Affinity Capture-MS; Affinity Capture-Western
PTPN11EGFR1082767673163 16729043 Affinity Capture-MS; Affinity Capture-Western
PTPN11EPHA211174510655584 Affinity Capture-Western
PTPN11EPHA210828810655584 Affinity Capture-Western
PTPN11EPOR1117458639815 Affinity Capture-Western
PTPN11EPOR1083718639815 Affinity Capture-Western
PTPN11ERBB211174516729043 Affinity Capture-MS
PTPN11ERBB210837616729043 Affinity Capture-MS
PTPN11ERBB411174516729043 Affinity Capture-MS
PTPN11ERBB410837816729043 Affinity Capture-MS
PTPN11PTK2B10848010880513 Affinity Capture-Western; Biochemical Activity; Far Western
PTPN11PTK2B11174510880513 Affinity Capture-Western; Biochemical Activity; Far Western
PTPN11FCGR2B11174510382761 Affinity Capture-Western
PTPN11FCGR2B10850710382761 Affinity Capture-Western
PTPN11FYN10881010212213 Affinity Capture-Western
PTPN11FYN11174510212213 Affinity Capture-Western
PTPN11GAB11088249658397 11940581 Affinity Capture-Western; Two-hybrid
PTPN11GAB11117459658397 11940581 Affinity Capture-Western; Two-hybrid
PTPN11GHR1089579632636 10976913 Reconstituted Complex
PTPN11GHR1117459632636 10976913 Reconstituted Complex
PTPN11GRB21091428041791 8702859 8995399 9362449 9632781 9824671 10080542 10212213 10747947 Affinity Capture-Western; Far Western; Reconstituted Complex
PTPN11GRB21117458041791 8702859 8995399 9362449 9632781 9824671 10080542 10212213 10747947 Affinity Capture-Western; Far Western; Reconstituted Complex
PTPN11IGF1R1097017642582 10082579 Affinity Capture-Western; Reconstituted Complex
PTPN11IGF1R1117457642582 10082579 Affinity Capture-Western; Reconstituted Complex
PTPN11IL4R10978011714803 Reconstituted Complex
PTPN11IL4R11174511714803 Reconstituted Complex
PTPN11IL6ST1117459388212 10946280 12403768 Affinity Capture-Western
PTPN11IL6ST1097869388212 10946280 12403768 Affinity Capture-Western
PTPN11INPP5D1098479110989 Affinity Capture-Western
PTPN11INPP5D1117459110989 Affinity Capture-Western
PTPN11INSR1098547493946 8135823 Affinity Capture-Western; Reconstituted Complex
PTPN11INSR1117457493946 8135823 Affinity Capture-Western; Reconstituted Complex
PTPN11IRS11117458505282 9756938 Affinity Capture-Western; Reconstituted Complex
PTPN11IRS11098748505282 9756938 Affinity Capture-Western; Reconstituted Complex
PTPN11JAK11099198995399 12403768 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PTPN11JAK11117458995399 12403768 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PTPN11JAK21099208639815 8912646 8995399 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PTPN11JAK21117458639815 8912646 8995399 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PTPN11KIT1100157523381 9528781 Affinity Capture-Western; Reconstituted Complex
PTPN11KIT1117457523381 9528781 Affinity Capture-Western; Reconstituted Complex
PTPN11LAIR11100989285412 10903717 Affinity Capture-Western
PTPN11LAIR11117459285412 10903717 Affinity Capture-Western
PTPN11LY911174511689425 Affinity Capture-Western
PTPN11LY911024111689425 Affinity Capture-Western
PTPN11PDGFRB1111857691811 11266449 Reconstituted Complex; Two-hybrid
PTPN11PDGFRB1117457691811 11266449 Reconstituted Complex; Two-hybrid
PTPN11PECAM11112019054388 9774457 10350061 10801826 Affinity Capture-Western; Far Western; Reconstituted Complex
PTPN11PECAM11117459054388 9774457 10350061 10801826 Affinity Capture-Western; Far Western; Reconstituted Complex
PTPN11PIK3R11117459918857 Affinity Capture-Western
PTPN11PIK3R11113139918857 Affinity Capture-Western
PTPN11PLCG211135212135708 Affinity Capture-Western
PTPN11PLCG211174512135708 Affinity Capture-Western
PTPN11PRLR11160310991949 Affinity Capture-Western
PTPN11PRLR11174510991949 Affinity Capture-Western
PTPN11PTK211171910082579 Affinity Capture-Western
PTPN11PTK211174510082579 Affinity Capture-Western
IRS2PTPN111142098910607 Affinity Capture-Western
IRS2PTPN111117458910607 Affinity Capture-Western
BCAR1PTPN111117459188452 Affinity Capture-Western
BCAR1PTPN111149349188452 Affinity Capture-Western
SOS1PTPN111125379344843 9632781 Affinity Capture-Western
SOS1PTPN111117459344843 9632781 Affinity Capture-Western
FRS2PTPN111160319632781 10650943 11360177 Affinity Capture-Western; Far Western; Two-hybrid
FRS2PTPN111117459632781 10650943 11360177 Affinity Capture-Western; Far Western; Two-hybrid
MPZL1PTPN111117459792637 Affinity Capture-Western
MPZL1PTPN111144869792637 Affinity Capture-Western
SYNCRIPPTPN111157559847309 Two-hybrid
SYNCRIPPTPN111117459847309 Two-hybrid
PTPN11PTPN111117459847309 Two-hybrid
LILRB4PTPN111117459973385 Protein-peptide
LILRB4PTPN111161979973385 Protein-peptide
SIT1PTPN1111808810209036 Affinity Capture-Western
SIT1PTPN1111174510209036 Affinity Capture-Western
GAB2PTPN1111518110391903 10871282 11334882 11782427 12135708 Affinity Capture-Western; Two-hybrid
GAB2PTPN1111174510391903 10871282 11334882 11782427 12135708 Affinity Capture-Western; Two-hybrid
STAT5APTPN1111265310617656 12060651 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT5APTPN1111174510617656 12060651 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT5BPTPN1111265410617656 Biochemical Activity; Reconstituted Complex
STAT5BPTPN1111174510617656 Biochemical Activity; Reconstituted Complex
PILRAPTPN1111901710903717 Affinity Capture-Western
PILRAPTPN1111174510903717 Affinity Capture-Western
ROS1PTPN1111202511266449 Two-hybrid
ROS1PTPN1111174511266449 Two-hybrid
SLAMF6PTPN1112537811489943 Affinity Capture-Western
SLAMF6PTPN1111174511489943 Affinity Capture-Western
C6orf25PTPN1112328311544253 Affinity Capture-Western
C6orf25PTPN1111174511544253 Affinity Capture-Western
STAT3PTPN1111265111594781 Affinity Capture-Western
STAT3PTPN1111174511594781 Affinity Capture-Western
SELEPTPN1111230111602579 Affinity Capture-Western
SELEPTPN1111174511602579 Affinity Capture-Western
SLAMF1PTPN1111239511689425 11806999 Affinity Capture-Western
SLAMF1PTPN1111174511689425 11806999 Affinity Capture-Western
CD84PTPN1111435911689425 Affinity Capture-Western
CD84PTPN1111174511689425 Affinity Capture-Western
GAB3PTPN1112658111739737 Affinity Capture-Western
GAB3PTPN1111174511739737 Affinity Capture-Western
SIGLEC11PTPN1112528511986327 Affinity Capture-Western
SIGLEC11PTPN1111174511986327 Affinity Capture-Western
FCRL3PTPN1112542812051764 Reconstituted Complex
FCRL3PTPN1111174512051764 Reconstituted Complex
SOCS3PTPN1111448812403768 Affinity Capture-Western; Reconstituted Complex
SOCS3PTPN1111174512403768 Affinity Capture-Western; Reconstituted Complex
BTLAPTPN1112741112796776 Affinity Capture-Western
BTLAPTPN1111174512796776 Affinity Capture-Western
TREML1PTPN1113101315128762 Affinity Capture-Western
TREML1PTPN1111174515128762 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
PTPN11CAT20900415556604 Cat interacts with Shp-2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99511
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-5911'