AutismKB 2.0

Annotation Details for PTPN12


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Basic Information Top
Gene Symbol:PTPN12 ( PTP-PEST,PTPG1 )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 12
Band: 7q11.23
Quick LinksEntrez ID:5782; OMIM: 600079; Uniprot ID:PTN12_HUMAN; ENSEMBL ID: ENSG00000127947; HGNC ID: 9645
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0002102IEA-podosome-
GO:0005737TAS-cytoplasm1472029
GO:0005829TAS-cytosol-
GO:0005925IEA-focal adhesion-
GO:0042995IEA-cell projection-
GO ID Evidence Qualifier GO_term References
GO:0004721IDA-phosphoprotein phosphatase activity27134172
GO:0004725EXP-protein tyrosine phosphatase activity21376233
GO:0004726TAS-non-membrane spanning protein tyrosine phosphatase activity8454633
GO:0005515IPI-protein binding9285683
GO:0017124IPI-SH3 domain binding9285683
GO ID Evidence Qualifier GO_term References
GO:0006470IDA-protein dephosphorylation27134172
GO:0035335IDA-peptidyl-tyrosine dephosphorylation27134172
GO:0038128TAS-ERBB2 signaling pathway-
GO:0042058IMP-regulation of epidermal growth factor receptor signaling pathway27134172
GO:0042246IEA-tissue regeneration-
GO:0071364IMP-cellular response to epidermal growth factor stimulus27134172
GO:1901185TAS-negative regulation of ERBB signaling pathway-
GO:2000587TAS-negative regulation of platelet-derived growth factor receptor-beta signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PTPN12EGFR11174620029029 PCA
PTPN12EGFR10827620029029 PCA
PTPN12PTK2B10848011337490 Biochemical Activity
PTPN12PTK2B11174611337490 Biochemical Activity
PTPN12GRB21091429135065 Affinity Capture-Western; Reconstituted Complex
PTPN12GRB21117469135065 Affinity Capture-Western; Reconstituted Complex
PTPN12GSN10918911577104 Affinity Capture-Western
PTPN12GSN11174611577104 Affinity Capture-Western
PTPN12JAK210992011731619 Affinity Capture-Western
PTPN12JAK211174611731619 Affinity Capture-Western
PTPN12NEDD91108169748319 Reconstituted Complex
PTPN12NEDD91117469748319 Reconstituted Complex
SHC1PTPN121117467929214 8626541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHC1PTPN121123617929214 8626541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCAR1PTPN121117468887669 9285683 9748319 12714323 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BCAR1PTPN121149348887669 9285683 9748319 12714323 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PSTPIP1PTPN121117469422760 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSTPIP1PTPN121145139422760 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PXNPTPN121117469497381 10400685 10625692 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PXNPTPN121117879497381 10400685 10625692 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EFSPTPN121117469748319 Reconstituted Complex
EFSPTPN121155679748319 Reconstituted Complex
TGFB1I1PTPN1211174610092676 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGFB1I1PTPN1211289910092676 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104673
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1441'