AutismKB 2.0

Annotation Details for PTPRC


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Basic Information Top
Gene Symbol:PTPRC ( B220,CD45,CD45R,GP180,LCA,LY5,T200 )
Gene Full Name: protein tyrosine phosphatase, receptor type, C
Band: 1q31.3-q32.1
Quick LinksEntrez ID:5788; OMIM: 151460; Uniprot ID:PTPRC_HUMAN; ENSEMBL ID: ENSG00000081237; HGNC ID: 9666
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887ISS-integral component of plasma membrane-
GO:0005925ISS-focal adhesion-
GO:0009897IDA-external side of plasma membrane17213291
GO:0009986IDA-cell surface24337748
GO:0016020IDA-membrane19946888
GO:0030667TAS-secretory granule membrane-
GO:0045121IEA-membrane raft-
GO:0070062IDA-extracellular exosome12519789
GO ID Evidence Qualifier GO_term References
GO:0004725IDA-protein tyrosine phosphatase activity2853967
GO:0004725TAS-protein tyrosine phosphatase activity-
GO:0005001TAS-transmembrane receptor protein tyrosine phosphatase activity2845400
GO:0005515IPI-protein binding1970422
GO:0019901IPI-protein kinase binding14625311
GO ID Evidence Qualifier GO_term References
GO:0001915ISS-negative regulation of T cell mediated cytotoxicity-
GO:0001960ISS-negative regulation of cytokine-mediated signaling pathway-
GO:0002244IMP-hematopoietic progenitor cell differentiation21911094
GO:0002378IMP-immunoglobulin biosynthetic process1793833
GO:0006469IDA-negative regulation of protein kinase activity9197241
GO:0006469ISS-negative regulation of protein kinase activity-
GO:0006470ISS-protein dephosphorylation-
GO:0006933IMP-negative regulation of cell adhesion involved in substrate-bound cell migration21911094
GO:0007166TAS-cell surface receptor signaling pathway2845400
GO:0016311ISS-dephosphorylation-
GO:0030217ISS-T cell differentiation-
GO:0030890IMP-positive regulation of B cell proliferation1793833
GO:0035335IEA-peptidyl-tyrosine dephosphorylation-
GO:0042100ISS-B cell proliferation-
GO:0042102ISS-positive regulation of T cell proliferation-
GO:0043312TAS-neutrophil degranulation-
GO:0044770IMP-cell cycle phase transition1793833
GO:0045860NAS-positive regulation of protein kinase activity15275963
GO:0048539IMP-bone marrow development21911094
GO:0048864IMP-stem cell development21911094
GO:0050852IDA-T cell receptor signaling pathway10358156
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050853ISS-B cell receptor signaling pathway-
GO:0050857ISS-positive regulation of antigen receptor-mediated signaling pathway-
GO:0051209ISS-release of sequestered calcium ion into cytosol-
GO:0051607ISS-defense response to virus-
GO:0051726ISS-regulation of cell cycle-
GO:2000473IMP-positive regulation of hematopoietic stem cell migration21911094
GO:2000648IMP-positive regulation of stem cell proliferation21911094
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PTPRCCD1D11175210473580 Affinity Capture-Western
PTPRCCD1D10735010473580 Affinity Capture-Western
PTPRCCD21117521970422 Reconstituted Complex
PTPRCCD21073521970422 Reconstituted Complex
PTPRCCD2471073577526385 Reconstituted Complex
PTPRCCD2471117527526385 Reconstituted Complex
PTPRCCD41073581834739 FRET
PTPRCCD41117521834739 FRET
PTPRCCD8A1073631834739 FRET
PTPRCCD8A1117521834739 FRET
PTPRCCD2211175210228003 Affinity Capture-Western
PTPRCCD2210737110228003 Affinity Capture-Western
PTPRCCD441117529573028 Co-fractionation
PTPRCCD441073989573028 Co-fractionation
PTPRCCD79A1117527516335 Affinity Capture-Western
PTPRCCD79A1074117516335 Affinity Capture-Western
PTPRCCD79B1117527516335 Affinity Capture-Western
PTPRCCD79B1074127516335 Affinity Capture-Western
PTPRCPLK311175211551930 Affinity Capture-Western
PTPRCPLK310766311551930 Affinity Capture-Western
PTPRCLCK1117528473339 8576115 15085197 Affinity Capture-Western; Reconstituted Complex
PTPRCLCK1101248473339 8576115 15085197 Affinity Capture-Western; Reconstituted Complex
PTPRCLGALS111175210490978 Affinity Capture-Western
PTPRCLGALS111014710490978 Affinity Capture-Western
PTPRCLYN1102457516335 Affinity Capture-Western; Reconstituted Complex
PTPRCLYN1117527516335 Affinity Capture-Western; Reconstituted Complex
PTPRCPAEP11175212556471 Co-localization
PTPRCPAEP11108412556471 Co-localization
PTPRCPRKCSH1115759148925 Affinity Capture-Western
PTPRCPRKCSH1117529148925 Affinity Capture-Western
PTPRCAPPTPRC1117528537410 Reconstituted Complex
PTPRCAPPTPRC1117548537410 Reconstituted Complex
SEMA4DPTPRC1117528955171 Affinity Capture-Western
SEMA4DPTPRC1157668955171 Affinity Capture-Western
GANABPTPRC1117529148925 10921916 11564800 Affinity Capture-Western; Reconstituted Complex
GANABPTPRC1168029148925 10921916 11564800 Affinity Capture-Western; Reconstituted Complex
SLAMF1PTPRC11175210229804 Affinity Capture-Western
SLAMF1PTPRC11239510229804 Affinity Capture-Western
SKAP1PTPRC11175211909961 Affinity Capture-Western; Two-hybrid
SKAP1PTPRC11418411909961 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97810
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050208-585'