AutismKB 2.0

Annotation Details for BAX


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Basic Information Top
Gene Symbol:BAX ( BCL2L4 )
Gene Full Name: BCL2-associated X protein
Band: 19q13.33
Quick LinksEntrez ID:581; OMIM: 600040; Uniprot ID:BAX_HUMAN; ENSEMBL ID: ENSG00000087088; HGNC ID: 959
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus12925958
GO:0005634IMP-nucleus15102863
GO:0005635IDA-nuclear envelope12925958
GO:0005737IDA-cytoplasm16302269
GO:0005739IDA-mitochondrion11912183
GO:0005741TAS-mitochondrial outer membrane-
GO:0005757IDA-mitochondrial permeability transition pore complex9843949
GO:0005783IDA-endoplasmic reticulum16424160
GO:0005789IDA-endoplasmic reticulum membrane16424160
GO:0005829IDA-cytosol11912183
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO:0046930IDA-pore complex9219694
GO:0070062IDA-extracellular exosome20458337
GO:0071944IDAcolocalizes_withcell periphery21803450
GO:0097136IDA-Bcl-2 family protein complex21199865
GO:0097144IDA-BAX complex19767770
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding9027312
GO:0008289IDA-lipid binding14522999
GO:0015267IDA-channel activity9219694
GO:0030544IEA-Hsp70 protein binding-
GO:0042802IPI-identical protein binding10620504
GO:0042803IDA-protein homodimerization activity16608847
GO:0042803IPI-protein homodimerization activity9111042
GO:0046982IPI-protein heterodimerization activity9111042
GO:0051087IEA-chaperone binding-
GO:0051434IDA-BH3 domain binding21199865
GO:0051434IPI-BH3 domain binding15705586
GO ID Evidence Qualifier GO_term References
GO:0001541IEA-ovarian follicle development-
GO:0001764IEA-neuron migration-
GO:0001777IEA-T cell homeostatic proliferation-
GO:0001782IEA-B cell homeostasis-
GO:0001783IDA-B cell apoptotic process15214043
GO:0001822IEA-kidney development-
GO:0001836IDA-release of cytochrome c from mitochondria9843949
GO:0001844TAS-protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
GO:0001974IEA-blood vessel remodeling-
GO:0002262IEA-myeloid cell homeostasis-
GO:0002352IEA-B cell negative selection-
GO:0002358IEA-B cell homeostatic proliferation-
GO:0002904IEA-positive regulation of B cell apoptotic process-
GO:0006687IEA-glycosphingolipid metabolic process-
GO:0006808IEA-regulation of nitrogen utilization-
GO:0006915IDA-apoptotic process9660918
GO:0006915IMP-apoptotic process9531611
GO:0006915NAS-apoptotic process9920818
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process11912183
GO:0006919IMP-activation of cysteine-type endopeptidase activity involved in apoptotic process11350920
GO:0006977TAS-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-
GO:0006987TAS-activation of signaling protein activity involved in unfolded protein response22013210
GO:0007281IEA-germ cell development-
GO:0008053IDA-mitochondrial fusion14769861
GO:0008625IC-extrinsic apoptotic signaling pathway via death domain receptors16199525
GO:0008630IEA-intrinsic apoptotic signaling pathway in response to DNA damage-
GO:0008635IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c15214043
GO:0008637IDA-apoptotic mitochondrial changes9843949
GO:0009566IEA-fertilization-
GO:0009636IDA-response to toxic substance16307838
GO:0009651IEA-response to salt stress-
GO:0010248IDA-establishment or maintenance of transmembrane electrochemical gradient9843949
GO:0010332IEA-response to gamma radiation-
GO:0016032IEA-viral process-
GO:0021854IEA-hypothalamus development-
GO:0021987IEA-cerebral cortex development-
GO:0032091IDA-negative regulation of protein binding9388232
GO:0032461IDA-positive regulation of protein oligomerization19805544
GO:0032469TAS-endoplasmic reticulum calcium ion homeostasis18309324
GO:0032471IEA-negative regulation of endoplasmic reticulum calcium ion concentration-
GO:0032976IDA-release of matrix enzymes from mitochondria9843949
GO:0033137IEA-negative regulation of peptidyl-serine phosphorylation-
GO:0033599IEA-regulation of mammary gland epithelial cell proliferation-
GO:0034644IEA-cellular response to UV-
GO:0035234IEA-ectopic germ cell programmed cell death-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0042981TAS-regulation of apoptotic process-
GO:0043065IMP-positive regulation of apoptotic process17289999
GO:0043496IDA-regulation of protein homodimerization activity9111042
GO:0043497IPI-regulation of protein heterodimerization activity9111042
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043525IDA-positive regulation of neuron apoptotic process15637643
GO:0043653IDA-mitochondrial fragmentation involved in apoptotic process12499352
GO:0045136IEA-development of secondary sexual characteristics-
GO:0046666IEA-retinal cell programmed cell death-
GO:0048087IEA-positive regulation of developmental pigmentation-
GO:0048147IEA-negative regulation of fibroblast proliferation-
GO:0048515IEA-spermatid differentiation-
GO:0048597IEA-post-embryonic camera-type eye morphogenesis-
GO:0048678IEA-response to axon injury-
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0051259IDA-protein oligomerization19074440
GO:0051260IDA-protein homooligomerization14522999
GO:0051281IEA-positive regulation of release of sequestered calcium ion into cytosol-
GO:0051402IEA-neuron apoptotic process-
GO:0051881IDA-regulation of mitochondrial membrane potential9843949
GO:0060011IEA-Sertoli cell proliferation-
GO:0060041IEA-retina development in camera-type eye-
GO:0060058IEA-positive regulation of apoptotic process involved in mammary gland involution-
GO:0060068IEA-vagina development-
GO:0070059IMP-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress16645094
GO:0070059TAS-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress22934019
GO:0070242IEA-thymocyte apoptotic process-
GO:0070584IEA-mitochondrion morphogenesis-
GO:0072332IEA-intrinsic apoptotic signaling pathway by p53 class mediator-
GO:0090200IDA-positive regulation of release of cytochrome c from mitochondria14963330
GO:0097190IDA-apoptotic signaling pathway16424160
GO:0097191IDA-extrinsic apoptotic signaling pathway15214043
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
GO:0097193IDA-intrinsic apoptotic signaling pathway9219694
GO:0097296IEA-activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-
GO:1900103IMP-positive regulation of endoplasmic reticulum unfolded protein response16645094
GO:1901030TAS-positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway-
GO:1902262IEA-apoptotic process involved in blood vessel morphogenesis-
GO:1902263IEA-apoptotic process involved in embryonic digit morphogenesis-
GO:1902445IEA-regulation of mitochondrial membrane permeability involved in programmed necrotic cell death-
GO:1902512IMP-positive regulation of apoptotic DNA fragmentation11350920
GO:1903896TAS-positive regulation of IRE1-mediated unfolded protein response22013210
GO:1990117IDA-B cell receptor apoptotic signaling pathway15214043
GO:2001234IEA-negative regulation of apoptotic signaling pathway-
GO:2001241IEA-positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-
GO:2001244IMP-positive regulation of intrinsic apoptotic signaling pathway14963330
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BAXSLC25A41070579748162 Affinity Capture-Western; Two-hybrid
BAXSLC25A41067889748162 Affinity Capture-Western; Two-hybrid
BAXBAK110705711571294 Affinity Capture-Western
BAXBAK110705411571294 Affinity Capture-Western
BCL2BAX1070688358790 10620799 14980220 15231068 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL2BAX1070578358790 10620799 14980220 15231068 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL2L1BAX1070579824152 12137781 12853473 Affinity Capture-Western; Protein-peptide
BCL2L1BAX1070709824152 12137781 12853473 Affinity Capture-Western; Protein-peptide
BCL2L2BAX10705710381646 Affinity Capture-Western
BCL2L2BAX10707110381646 Affinity Capture-Western
BCL2A1BAX10705710753914 Reconstituted Complex; Two-hybrid
BCL2A1BAX10706910753914 Reconstituted Complex; Two-hybrid
MCL1BAX10705710837489 Two-hybrid
MCL1BAX11033810837489 Two-hybrid
MOAP1BAX12206911060313 Affinity Capture-Western
MOAP1BAX10705711060313 Affinity Capture-Western
SH3GLB1BAX11928911161816 11259440 Affinity Capture-Western; Two-hybrid
SH3GLB1BAX10705711161816 11259440 Affinity Capture-Western; Two-hybrid
BAXBAX10705711161816 Two-hybrid
BCL2L10BAX11533411278245 Affinity Capture-Western
BCL2L10BAX10705711278245 Affinity Capture-Western
SNCABAX10705711742726 Reconstituted Complex
SNCABAX11250611742726 Reconstituted Complex
HSPD1BAX10956112070120 Affinity Capture-Western
HSPD1BAX10705712070120 Affinity Capture-Western
YWHAQBAX11616812426317 Affinity Capture-Western; Reconstituted Complex
YWHAQBAX10705712426317 Affinity Capture-Western; Reconstituted Complex
VDAC1BAX10705712767928 15637055 Reconstituted Complex
VDAC1BAX11325912767928 15637055 Reconstituted Complex
BNIPLBAX12721112901880 Two-hybrid
BNIPLBAX10705712901880 Two-hybrid
PMAIP1BAX11137915705586 Affinity Capture-Western
PMAIP1BAX10705715705586 Affinity Capture-Western
TOMM40BAX11571617635912 Affinity Capture-Western
TOMM40BAX10705717635912 Affinity Capture-Western
TOMM22BAX12130817635912 Affinity Capture-Western
TOMM22BAX10705717635912 Affinity Capture-Western
MEPCEBAX12112217643375 Affinity Capture-MS
MEPCEBAX10705717643375 Affinity Capture-MS
UBCBAX11316418362350 Affinity Capture-Western
UBCBAX10705718362350 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
SH3GLB1BAX20923211161816 An unspecified isoform of Bax interacts with SH3GLB1.
CRYAABAX18555514752512 HalphaA-crystallin interacts with Bax.
CRYABBAX18555614752512 HalphaB-crystallin interacts with Bax.
MOAP1BAX29745615949439 MAP-1 interacts with an unspecified isoform of Bax.
BCL2L1BAX1967609372935 Bax interacts with Bcl-XL.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
BAXrs1805419 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:99702
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000511-6'