AutismKB 2.0

Annotation Details for NLRC4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NLRC4 ( CARD12,CLAN,CLAN1,CLANA,CLANB,CLANC,CLAND,CLR2.1,IPAF )
Gene Full Name: NLR family, CARD domain containing 4
Band: 2p22.3
Quick LinksEntrez ID:58484; OMIM: 606831; Uniprot ID:NLRC4_HUMAN; ENSEMBL ID: ENSG00000091106; HGNC ID: 16412
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622NAS-intracellular15107016
GO:0005634IBA-nucleus-
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0072557IBA-IPAF inflammasome complex-
GO:0072557ISS-IPAF inflammasome complex-
GO ID Evidence Qualifier GO_term References
GO:0000287TAS-magnesium ion binding15882992
GO:0004842IBA-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11374873
GO:0005524IDA-ATP binding15882992
GO:0042802IPI-identical protein binding11374873
GO:0042803IDA-protein homodimerization activity15107016
GO:0043027IBA-cysteine-type endopeptidase inhibitor activity involved in apoptotic process-
GO ID Evidence Qualifier GO_term References
GO:0002218ISS-activation of innate immune response-
GO:0006915IEA-apoptotic process-
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process15030775
GO:0006954ISS-inflammatory response-
GO:0009966IBA-regulation of signal transduction-
GO:0016045IDA-detection of bacterium15107016
GO:0016567IEA-protein ubiquitination-
GO:0042742IDA-defense response to bacterium15107016
GO:0042981TAS-regulation of apoptotic process-
GO:0043065IDA-positive regulation of apoptotic process12646168
GO:0045087IBA-innate immune response-
GO:0050702IDA-interleukin-1 beta secretion15882992
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity12646168
GO:0051260ISS-protein homooligomerization-
GO:0070269ISS-pyroptosis-
GO:0090307IBANOTmitotic spindle assembly-
GO:1990001IBA-inhibition of cysteine-type endopeptidase activity involved in apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLRC4CASP110728411472070 15107016 Affinity Capture-Western
NLRC4CASP112181411472070 15107016 Affinity Capture-Western
NLRC4NA11074515107016 Affinity Capture-Western
NLRC4NA12181415107016 Affinity Capture-Western
NLRC4NAIP11075215107016 Affinity Capture-Western
NLRC4NAIP12181415107016 Affinity Capture-Western
NLRC4BCL1011442911472070 Affinity Capture-Western
NLRC4BCL1012181411472070 Affinity Capture-Western
NLRC4NOD111566415107016 Affinity Capture-Western
NLRC4NOD112181415107016 Affinity Capture-Western
NLRC4NLRP112181411472070 Affinity Capture-Western
NLRC4NLRP111652911472070 Affinity Capture-Western
NLRC4PYCARD12181411374873 Two-hybrid
NLRC4PYCARD11887611374873 Two-hybrid
NLRC4NLRC412181411472070 15107016 Affinity Capture-Western
NOD2NLRC412207711472070 15107016 Affinity Capture-Western
NOD2NLRC412181411472070 15107016 Affinity Capture-Western
NLRP3NLRC412531915107016 Affinity Capture-Western
NLRP3NLRC412181415107016 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
NLRC4CASP121660815107016 CARD12 (CLAN) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD12 and CASP1 from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:3036243
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved