AutismKB 2.0

Annotation Details for RAC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAC1 ( MGC111543,TC-25,p21-Rac1 )
Gene Full Name: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Band: 7p22.1
Quick LinksEntrez ID:5879; OMIM: 602048; Uniprot ID:RAC1_HUMAN; ENSEMBL ID: ENSG00000136238; HGNC ID: 9801
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005737IDA-cytoplasm19625648
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005802IDA-trans-Golgi network12915445
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005884IDAcolocalizes_withactin filament19625648
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0016020ISS-membrane-
GO:0030027IDA-lamellipodium19625648
GO:0030667TAS-secretory granule membrane-
GO:0031012IDA-extracellular matrix23979707
GO:0036464IDA-cytoplasmic ribonucleoprotein granule15121898
GO:0042470IEA-melanosome-
GO:0043197IDA-dendritic spine24352656
GO:0070062IDA-extracellular exosome20458337
GO:0101003TAS-ficolin-1-rich granule membrane-
GO ID Evidence Qualifier GO_term References
GO:0003924TAS-GTPase activity9312003
GO:0005515IPI-protein binding7673236
GO:0005525IDA-GTP binding15467718
GO:0005525IMP-GTP binding19625648
GO:0017137IEA-Rab GTPase binding-
GO:0019899IPI-enzyme binding16636067
GO:0019901IPI-protein kinase binding8625410
GO:0031996IPI-thioesterase binding12612085
GO:0042826IEA-histone deacetylase binding-
GO:0051022ISS-Rho GDP-dissociation inhibitor binding-
GO:0051117IEA-ATPase binding-
GO ID Evidence Qualifier GO_term References
GO:0001934IMP-positive regulation of protein phosphorylation23633677
GO:0002551IEA-mast cell chemotaxis-
GO:0006928TAS-movement of cell or subcellular component9572733
GO:0006954TAS-inflammatory response9572733
GO:0007155TAS-cell adhesion9572733
GO:0007160NAS-cell-matrix adhesion18156211
GO:0007596TAS-blood coagulation-
GO:0008283IEA-cell proliferation-
GO:0008361IGI-regulation of cell size22467863
GO:0008361IMP-regulation of cell size22467863
GO:0009611TAS-response to wounding9572733
GO:0009653TAS-anatomical structure morphogenesis9572733
GO:0010310TAS-regulation of hydrogen peroxide metabolic process16636067
GO:0010591IGI-regulation of lamellipodium assembly8625410
GO:0010592IDA-positive regulation of lamellipodium assembly15467718
GO:0010592IMP-positive regulation of lamellipodium assembly8625410
GO:0010811IGI-positive regulation of cell-substrate adhesion20926685
GO:0016601IEA-Rac protein signal transduction-
GO:0030032IMP-lamellipodium assembly9312003
GO:0030036IGI-actin cytoskeleton organization19890013
GO:0030041TAS-actin filament polymerization9312003
GO:0030168TAS-platelet activation-
GO:0030334IMP-regulation of cell migration19934221
GO:0031116IMP-positive regulation of microtubule polymerization25198505
GO:0031295TAS-T cell costimulation-
GO:0031529IDA-ruffle organization15467718
GO:0031529TAS-ruffle organization9312003
GO:0032707IDA-negative regulation of interleukin-23 production16982892
GO:0034446IMP-substrate adhesion-dependent cell spreading19625648
GO:0035025TAS-positive regulation of Rho protein signal transduction9312003
GO:0035556TAS-intracellular signal transduction9572733
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043312TAS-neutrophil degranulation-
GO:0045453IEA-bone resorption-
GO:0045740IEA-positive regulation of DNA replication-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048012IMP-hepatocyte growth factor receptor signaling pathway25198505
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048261TAS-negative regulation of receptor-mediated endocytosis9312003
GO:0048870IDA-cell motility19403692
GO:0050690TAS-regulation of defense response to virus by virus-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0051492IGI-regulation of stress fiber assembly8625410
GO:0051496IDA-positive regulation of stress fiber assembly23129259
GO:0051496IMP-positive regulation of stress fiber assembly8625410
GO:0051668IMP-localization within membrane16636067
GO:0051894IDA-positive regulation of focal adhesion assembly23129259
GO:0060071NAS-Wnt signaling pathway, planar cell polarity pathway24431302
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0060263IDA-regulation of respiratory burst16636067
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071526ISS-semaphorin-plexin signaling pathway-
GO:0090023IMP-positive regulation of neutrophil chemotaxis19625648
GO:1900026IDA-positive regulation of substrate adhesion-dependent cell spreading23129259
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAC1ACTB10657511027608 Far Western
RAC1ACTB11181711027608 Far Western
RAC1ARHGAP11068859535855 Reconstituted Complex
RAC1ARHGAP11118179535855 Reconstituted Complex
RAC1ARHGDIA1068899490022 10673424 11368848 11513578 11513579 17353931 Affinity Capture-MS; Co-crystal Structure; Co-purification; Reconstituted Complex; Two-hybrid
RAC1ARHGDIA1118179490022 10673424 11368848 11513578 11513579 17353931 Affinity Capture-MS; Co-crystal Structure; Co-purification; Reconstituted Complex; Two-hybrid
RAC1BCR1070839535855 Reconstituted Complex
RAC1BCR1118179535855 Reconstituted Complex
RAC1FMNL110720810958683 Affinity Capture-Western; Reconstituted Complex
RAC1FMNL111181710958683 Affinity Capture-Western; Reconstituted Complex
RAC1CDC421118179427749 Two-hybrid
RAC1CDC421074339427749 Two-hybrid
RAC1CSN210783420936779 Two-hybrid
RAC1CSN211181720936779 Two-hybrid
RAC1DMPK10810010869570 Reconstituted Complex
RAC1DMPK11181710869570 Reconstituted Complex
RAC1DOCK11081289808620 Reconstituted Complex
RAC1DOCK11118179808620 Reconstituted Complex
RAC1DOCK211181710559471 Reconstituted Complex
RAC1DOCK210812910559471 Reconstituted Complex
RAC1IL1RAP10977111416133 Affinity Capture-Western
RAC1IL1RAP11181711416133 Affinity Capture-Western
RAC1KPNA411003820936779 Two-hybrid
RAC1KPNA411181720936779 Two-hybrid
RAC1KTN11100928769096 Two-hybrid
RAC1KTN11118178769096 Two-hybrid
RAC1MAP3K41103809079650 Reconstituted Complex
RAC1MAP3K41118179079650 Reconstituted Complex
RAC1MAP3K101104409427749 Reconstituted Complex
RAC1MAP3K101118179427749 Reconstituted Complex
RAC1MYD8811181711416133 Affinity Capture-Western; Reconstituted Complex
RAC1MYD8811070011416133 Affinity Capture-Western; Reconstituted Complex
RAC1MYH911071220936779 Two-hybrid
RAC1MYH911181720936779 Two-hybrid
RAC1NCF21107689624165 9642115 11090627 Co-crystal Structure; Reconstituted Complex
RAC1NCF21118179624165 9642115 11090627 Co-crystal Structure; Reconstituted Complex
RAC1NME111181711274357 Biochemical Activity
RAC1NME111089411274357 Biochemical Activity
RAC1NOS211181711457725 Reconstituted Complex
RAC1NOS211090611457725 Reconstituted Complex
RAC1OPHN11110299582072 Biochemical Activity
RAC1OPHN11118179582072 Biochemical Activity
RAC1PAK11110959535855 12650940 12879077 20936779 Reconstituted Complex; Two-hybrid
RAC1PAK11118179535855 12650940 12879077 20936779 Reconstituted Complex; Two-hybrid
RAC1PAK21110989535855 20936779 Reconstituted Complex; Two-hybrid
RAC1PAK21118179535855 20936779 Reconstituted Complex; Two-hybrid
RAC1PAK311109911478794 Reconstituted Complex; Two-hybrid
RAC1PAK311181711478794 Reconstituted Complex; Two-hybrid
RAC1PARK211110516169070 Two-hybrid
RAC1PARK211181716169070 Two-hybrid
RAC1PTK211171920936779 Two-hybrid
RAC1PTK211181720936779 Two-hybrid
RAC1RGL21118018939933 Two-hybrid
RAC1RGL21118178939933 Two-hybrid
RALBP1RAC11161317673236 Two-hybrid
RALBP1RAC11118177673236 Two-hybrid
MCF2LRAC11168657957046 14701795 Affinity Capture-Western; Reconstituted Complex
MCF2LRAC11118177957046 14701795 Affinity Capture-Western; Reconstituted Complex
CITRAC11118178543060 Far Western
CITRAC11162908543060 Far Western
WASRAC11132938643625 Reconstituted Complex
WASRAC11118178643625 Reconstituted Complex
IQGAP1RAC11143538670801 8798539 9535855 12110184 Affinity Capture-Western; Reconstituted Complex
IQGAP1RAC11118178670801 8798539 9535855 12110184 Affinity Capture-Western; Reconstituted Complex
ARFIP2RAC11171748670882 11346801 11478794 Co-crystal Structure; Reconstituted Complex; Two-hybrid
ARFIP2RAC11118178670882 11346801 11478794 Co-crystal Structure; Reconstituted Complex; Two-hybrid
IQGAP2RAC11118178756646 Affinity Capture-Western; Reconstituted Complex
IQGAP2RAC11160048756646 Affinity Capture-Western; Reconstituted Complex
KALRNRAC11144789139723 Reconstituted Complex
KALRNRAC11118179139723 Reconstituted Complex
NCKAP1RAC11118179148763 Affinity Capture-Western; Reconstituted Complex
NCKAP1RAC11160039148763 Affinity Capture-Western; Reconstituted Complex
CNTNAP1RAC11140789535855 Reconstituted Complex
CNTNAP1RAC11118179535855 Reconstituted Complex
VAV3RAC111571510523675 Reconstituted Complex
VAV3RAC111181710523675 Reconstituted Complex
CDC42SE1RAC112121510816584 Two-hybrid
CDC42SE1RAC111181710816584 Two-hybrid
CDC42SE2RAC112130610816584 Two-hybrid
CDC42SE2RAC111181710816584 Two-hybrid
PARD6ARAC111181710873802 11260256 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PARD6ARAC111915710873802 11260256 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGEF4RAC111911410947987 20936779 Reconstituted Complex; Two-hybrid
ARHGEF4RAC111181710947987 20936779 Reconstituted Complex; Two-hybrid
STAT3RAC111265111021801 Affinity Capture-Western; Two-hybrid
STAT3RAC111181711021801 Affinity Capture-Western; Two-hybrid
SYNJ2RAC111439111084340 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SYNJ2RAC111181711084340 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TIAM1RAC111181711130063 11595749 Co-crystal Structure; Reconstituted Complex
TIAM1RAC111293011130063 11595749 Co-crystal Structure; Reconstituted Complex
BAIAP2RAC111572111130076 Reconstituted Complex
BAIAP2RAC111181711130076 Reconstituted Complex
RAC1RAC111181711134022 Reconstituted Complex
PARD6GRAC112413511260256 Reconstituted Complex
PARD6GRAC111181711260256 Reconstituted Complex
PARD6BRAC112414511260256 Reconstituted Complex; Two-hybrid
PARD6BRAC111181711260256 Reconstituted Complex; Two-hybrid
VAV1RAC111325211287617 Affinity Capture-Western
VAV1RAC111181711287617 Affinity Capture-Western
TECRAC111181711328862 Phenotypic Enhancement
TECRAC111286511328862 Phenotypic Enhancement
ARHGAP17RAC112042411431473 Biochemical Activity
ARHGAP17RAC111181711431473 Biochemical Activity
ARHGAP44RAC111524111431473 Biochemical Activity
ARHGAP44RAC111181711431473 Biochemical Activity
FHOD1RAC111181711590143 Affinity Capture-Western; Reconstituted Complex
FHOD1RAC111887711590143 Affinity Capture-Western; Reconstituted Complex
TRIORAC111305511595749 Reconstituted Complex
TRIORAC111181711595749 Reconstituted Complex
ARHGEF2RAC111461811595749 Reconstituted Complex
ARHGEF2RAC111181711595749 Reconstituted Complex
PAK4RAC111558611756552 Affinity Capture-Western
PAK4RAC111181711756552 Affinity Capture-Western
PAK7RAC112140211756552 Affinity Capture-Western
PAK7RAC111181711756552 Affinity Capture-Western
PLEKHG2RAC112233011839748 Reconstituted Complex
PLEKHG2RAC111181711839748 Reconstituted Complex
RAP1GDS1RAC111184511948427 20936779 Two-hybrid
RAP1GDS1RAC111181711948427 20936779 Two-hybrid
TNFRAC111181712006387 Phenotypic Suppression
TNFRAC111297912006387 Phenotypic Suppression
CLIP1RAC111216312110184 Affinity Capture-Western
CLIP1RAC111181712110184 Affinity Capture-Western
ARHGAP32RAC111509112454018 12819203 Biochemical Activity
ARHGAP32RAC111181712454018 12819203 Biochemical Activity
ARHGEF25RAC112543812547822 Reconstituted Complex
ARHGEF25RAC111181712547822 Reconstituted Complex
TBC1D3FRAC112395212612085 Reconstituted Complex
TBC1D3FRAC111181712612085 Reconstituted Complex
ARHGAP15RAC112094512650940 Reconstituted Complex
ARHGAP15RAC111181712650940 Reconstituted Complex
DEF6RAC111909915023524 Reconstituted Complex
DEF6RAC111181715023524 Reconstituted Complex
ARHGAP27RAC112836915147912 Biochemical Activity
ARHGAP27RAC111181715147912 Biochemical Activity
CDC42BPGRAC112071915194684 Reconstituted Complex
CDC42BPGRAC111181715194684 Reconstituted Complex
DOCK8RAC111181715304341 Two-hybrid
DOCK8RAC112357715304341 Two-hybrid
COG5RAC111572920936779 Two-hybrid
COG5RAC111181720936779 Two-hybrid
CCDC104RAC112521820936779 Two-hybrid
CCDC104RAC111181720936779 Two-hybrid
ARHGAP33RAC112544820936779 Two-hybrid
ARHGAP33RAC111181720936779 Two-hybrid
ARL2BPRAC111181720936779 Two-hybrid
ARL2BPRAC111711020936779 Two-hybrid
KPNA6RAC111716320936779 Two-hybrid
KPNA6RAC111181720936779 Two-hybrid
ARHGAP31RAC111181720936779 Two-hybrid
ARHGAP31RAC112157820936779 Two-hybrid
SH3RF1RAC112167320936779 Two-hybrid
SH3RF1RAC111181720936779 Two-hybrid
SFPQRAC111231920936779 Two-hybrid
SFPQRAC111181720936779 Two-hybrid
UBCRAC111316420936779 Two-hybrid
UBCRAC111181720936779 Two-hybrid
MCM3APRAC111440620936779 Two-hybrid
MCM3APRAC111181720936779 Two-hybrid
HPS4RAC112460020936779 Two-hybrid
HPS4RAC111181720936779 Two-hybrid
LATS1RAC111456320936779 Two-hybrid
LATS1RAC111181720936779 Two-hybrid
MAGI1RAC111465520936779 Two-hybrid
MAGI1RAC111181720936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
ARHGEF6RAC119709815649357 ARHGEF6 (Cool-2) interacts with Rac1.
RALBP1RAC11968297673236 Rac1 interacts with RLIP76.
TNFRSF12ARAC118182714573547 Fn14 interacts with Rac1.
DEF6RAC118242215023524 DEF6 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human DEF6 and Rac1 from an unspecified species.
TCF7L2RAC120938115377999 Rac1 interacts with TCF4.
ARHGAP8RAC129737912944407 BPGAP1 interacts with Rac1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97845
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-5415'