AutismKB 2.0

Annotation Details for RAC2


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Basic Information Top
Gene Symbol:RAC2 ( EN-7,Gx,HSPC022 )
Gene Full Name: ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Band: 22q13.1
Quick LinksEntrez ID:5880; OMIM: 602049; Uniprot ID:RAC2_HUMAN; ENSEMBL ID: ENSG00000128340; HGNC ID: 9802
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005635IEA-nuclear envelope-
GO:0005829IDA-cytosol19625648
GO:0005829TAS-cytosol-
GO:0005884IDAcolocalizes_withactin filament19625648
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0030027IDA-lamellipodium19625648
GO:0030670TAS-phagocytic vesicle membrane-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0003924IEA-GTPase activity-
GO:0005525IMP-GTP binding19625648
GO:0019887IEA-protein kinase regulator activity-
GO ID Evidence Qualifier GO_term References
GO:0006935IEA-chemotaxis-
GO:0007015IMP-actin filament organization21167572
GO:0007165TAS-signal transduction2674130
GO:0007186IEA-G-protein coupled receptor signaling pathway-
GO:0007264IEA-small GTPase mediated signal transduction-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0010310TAS-regulation of hydrogen peroxide metabolic process16636067
GO:0010592IMP-positive regulation of lamellipodium assembly19625648
GO:0010810IMP-regulation of cell-substrate adhesion21167572
GO:0030031IEA-cell projection assembly-
GO:0030168TAS-platelet activation-
GO:0042129IEA-regulation of T cell proliferation-
GO:0043304IEA-regulation of mast cell degranulation-
GO:0045453IEA-bone resorption-
GO:0045859IEA-regulation of protein kinase activity-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0060263IDA-regulation of respiratory burst16636067
GO:0060753IEA-regulation of mast cell chemotaxis-
GO:0071593IMP-lymphocyte aggregation21167572
GO:0090023IMP-positive regulation of neutrophil chemotaxis19625648
GO:1902622IMP-regulation of neutrophil migration21167572
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24270810
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAC2ACTB10657511027608 Far Western
RAC2ACTB11181811027608 Far Western
RAC2ARHGDIA1068899490022 11368848 Co-purification; Two-hybrid
RAC2ARHGDIA1118189490022 11368848 Co-purification; Two-hybrid
RAC2ARHGDIB10689010655614 Co-crystal Structure
RAC2ARHGDIB11181810655614 Co-crystal Structure
RAC2DOCK211181810559471 Reconstituted Complex
RAC2DOCK210812910559471 Reconstituted Complex
RAC2NCF21107689624165 9642115 Reconstituted Complex; Two-hybrid
RAC2NCF21118189624165 9642115 Reconstituted Complex; Two-hybrid
RAC2NOS211181811457725 Affinity Capture-Western; Reconstituted Complex
RAC2NOS211090611457725 Affinity Capture-Western; Reconstituted Complex
RAC2PAK211109812176041 Reconstituted Complex
RAC2PAK211181812176041 Reconstituted Complex
ICMTRAC21118189614111 Biochemical Activity
ICMTRAC21170269614111 Biochemical Activity
CUL1RAC211403211445862 Two-hybrid
CUL1RAC211181811445862 Two-hybrid
DEF6RAC211909915023524 Reconstituted Complex
DEF6RAC211181815023524 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
RAC2rs739043 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:97846
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040625-27'