AutismKB 2.0

Annotation Details for RAF1


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Basic Information Top
Gene Symbol:RAF1 ( CRAF,NS5,Raf-1,c-Raf )
Gene Full Name: v-raf-1 murine leukemia viral oncogene homolog 1
Band: 3p25.2
Quick LinksEntrez ID:5894; OMIM: 164760; Uniprot ID:RAF1_HUMAN; ENSEMBL ID: ENSG00000132155; HGNC ID: 9829
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm17724343
GO:0005737ISS-cytoplasm-
GO:0005741TAS-mitochondrial outer membrane8929532
GO:0005794IPI-Golgi apparatus17724343
GO:0005829IDA-cytosol16009725
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane17724343
GO:0005886IDAcolocalizes_withplasma membrane16009725
GO:0005886TAS-plasma membrane-
GO:0016607IDA-nuclear speck-
GO:0031143IEA-pseudopodium-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity8063729
GO:0004674IDA-protein serine/threonine kinase activity19667065
GO:0004709IBA-MAP kinase kinase kinase activity-
GO:0005515IPI-protein binding7644510
GO:0005524IEA-ATP binding-
GO:0016301TAS-kinase activity-
GO:0019899IPI-enzyme binding23509299
GO:0031267IPINOTsmall GTPase binding12194967
GO:0031434IBA-mitogen-activated protein kinase kinase binding-
GO:0042802IPI-identical protein binding17979178
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000186IDA-activation of MAPKK activity10644344
GO:0001666IEA-response to hypoxia-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006468TAS-protein phosphorylation8063729
GO:0006915TAS-apoptotic process8929532
GO:0007165TAS-signal transduction8063729
GO:0007190NAS-activation of adenylate cyclase activity15385642
GO:0007275IBA-multicellular organism development-
GO:0007507IEA-heart development-
GO:0008283TAS-cell proliferation8063729
GO:0008285IDA-negative regulation of cell proliferation9765203
GO:0009968IBA-negative regulation of signal transduction-
GO:0030154IEA-cell differentiation-
GO:0030168TAS-platelet activation-
GO:0030878IEA-thyroid gland development-
GO:0031333IDA-negative regulation of protein complex assembly19667065
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation19667065
GO:0034220TAS-ion transmembrane transport-
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035023TAS-regulation of Rho protein signal transduction16649144
GO:0035773IEA-insulin secretion involved in cellular response to glucose stimulus-
GO:0035994IEA-response to muscle stretch-
GO:0042060TAS-wound healing15943972
GO:0042981TAS-regulation of apoptotic process21779496
GO:0043066IDA-negative regulation of apoptotic process19667065
GO:0043154TAS-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process21779496
GO:0045104IEA-intermediate filament cytoskeleton organization-
GO:0045595TAS-regulation of cell differentiation21779496
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048011IEA-neurotrophin TRK receptor signaling pathway-
GO:0048538IEA-thymus development-
GO:0060324IEA-face development-
GO:0070374IBA-positive regulation of ERK1 and ERK2 cascade-
GO:0071550IEA-death-inducing signaling complex assembly-
GO:1902042IEA-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:2000145TAS-regulation of cell motility21779496
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAF1AKT110671010576742 Affinity Capture-Western; Biochemical Activity
RAF1AKT111183110576742 Affinity Capture-Western; Biochemical Activity
RAF1BIRC210682619011619 Reconstituted Complex
RAF1BIRC211183119011619 Reconstituted Complex
RAF1BIRC310682719011619 Reconstituted Complex
RAF1BIRC311183119011619 Reconstituted Complex
RAF1XIAP10682819011619 Affinity Capture-Western
RAF1XIAP11183119011619 Affinity Capture-Western
RAF1AR1118318349631 Co-purification
RAF1AR1068628349631 Co-purification
RAF1BAG11070498692945 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1BAG11118318692945 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1BCL21070688929532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1BCL21118318929532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1BCL2L11070708929532 Reconstituted Complex
RAF1BCL2L11118318929532 Reconstituted Complex
RAF1BRAF10714111325826 Affinity Capture-Western
RAF1BRAF11183111325826 Affinity Capture-Western
RAF1CDC25A1074287744247 9230211 Affinity Capture-Western; Reconstituted Complex
RAF1CDC25A1118317744247 9230211 Affinity Capture-Western; Reconstituted Complex
RAF1TSC22D311183112391160 Affinity Capture-Western; Reconstituted Complex
RAF1TSC22D310816512391160 Affinity Capture-Western; Reconstituted Complex
RAF1EEF1A111183117332776 Affinity Capture-Western; Co-localization
RAF1EEF1A110823717332776 Affinity Capture-Western; Co-localization
RAF1FYN1088107517401 Affinity Capture-Western; Reconstituted Complex
RAF1FYN1118317517401 Affinity Capture-Western; Reconstituted Complex
RAF1GNB21118317782277 Affinity Capture-Western
RAF1GNB21090457782277 Affinity Capture-Western
RAF1GNG41118317782277 Reconstituted Complex
RAF1GNG41090487782277 Reconstituted Complex
RAF1SFN11183115778465 Affinity Capture-MS
RAF1SFN10907215778465 Affinity Capture-MS
RAF1GRB101118319553107 10585452 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
RAF1GRB101091449553107 10585452 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
RAF1NR3C111183111005817 Affinity Capture-Western
RAF1NR3C110916511005817 Affinity Capture-Western
RAF1HRAS1118317862125 7969158 8530446 8628317 9150145 9154803 9523700 10369681 10783161 10882715 10922060 12379659 12620389 14654780 14724584 15031288 16803888 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1HRAS1095017862125 7969158 8530446 8628317 9150145 9154803 9523700 10369681 10783161 10882715 10922060 12379659 12620389 14654780 14724584 15031288 16803888 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1ERAS11183112774123 Affinity Capture-Western
RAF1ERAS10950212774123 Affinity Capture-Western
RAF1HSP90AA11118318408024 16504566 17409432 17699868 19011619 20159553 Affinity Capture-Western
RAF1HSP90AA11095528408024 16504566 17409432 17699868 19011619 20159553 Affinity Capture-Western
RAF1JAK11118319446616 Affinity Capture-Western
RAF1JAK11099199446616 Affinity Capture-Western
RAF1JAK21118318876196 Reconstituted Complex
RAF1JAK21099208876196 Reconstituted Complex
RAF1KRAS11183110783161 10882715 Affinity Capture-Western; Two-hybrid
RAF1KRAS11004310783161 10882715 Affinity Capture-Western; Two-hybrid
RAF1LCK1118318939988 Affinity Capture-Western
RAF1LCK1101248939988 Affinity Capture-Western
RAF1LRPAP111183110783161 Two-hybrid
RAF1LRPAP111022110783161 Two-hybrid
RAF1LTK1118318084603 Affinity Capture-Western
RAF1LTK1102368084603 Affinity Capture-Western
RAF1MAP3K111183110969079 Affinity Capture-Western; Reconstituted Complex
RAF1MAP3K111037810969079 Affinity Capture-Western; Reconstituted Complex
RAF1MAP3K511183111427728 Affinity Capture-Western; Reconstituted Complex
RAF1MAP3K511038111427728 Affinity Capture-Western; Reconstituted Complex
RAF1MYC1118319315742 Reconstituted Complex
RAF1MYC1106949315742 Reconstituted Complex
RAF1NRAS11183110882715 Affinity Capture-Western
RAF1NRAS11095210882715 Affinity Capture-Western
RAF1PEBP111183110757792 Affinity Capture-Western; Reconstituted Complex
RAF1PEBP111107610757792 Affinity Capture-Western; Reconstituted Complex
RAF1PAK111183111733498 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RAF1PAK111109511733498 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RAF1PDGFRB1118312475255 Reconstituted Complex
RAF1PDGFRB1111852475255 Reconstituted Complex
RAF1PHB11126410523633 Affinity Capture-Western; Reconstituted Complex
RAF1PHB11183110523633 Affinity Capture-Western; Reconstituted Complex
RAF1PHKA211127412620389 Two-hybrid
RAF1PHKA211183112620389 Two-hybrid
RAF1PRKCE11183111350735 Affinity Capture-Western
RAF1PRKCE11156711350735 Affinity Capture-Western
RAF1PRKCZ11183110620507 Affinity Capture-Western; Reconstituted Complex
RAF1PRKCZ11157610620507 Affinity Capture-Western; Reconstituted Complex
RAF1PRKG111183112237340 Affinity Capture-Western
RAF1PRKG111157812237340 Affinity Capture-Western
RAF1MAPK111183111409918 Affinity Capture-Western
RAF1MAPK111158011409918 Affinity Capture-Western
RAF1MAPK311183111409918 Affinity Capture-Western
RAF1MAPK311158111409918 Affinity Capture-Western
RAF1MAPK711183110531364 Affinity Capture-Western; Reconstituted Complex
RAF1MAPK711158410531364 Affinity Capture-Western; Reconstituted Complex
RAF1MAP2K111183110757792 15485920 Affinity Capture-Western; Reconstituted Complex
RAF1MAP2K111159010757792 15485920 Affinity Capture-Western; Reconstituted Complex
SRCRAF11118317517401 Affinity Capture-Western; Reconstituted Complex
SRCRAF11125927517401 Affinity Capture-Western; Reconstituted Complex
YWHAZRAF11133667628630 9261098 10611249 10620507 10887173 Affinity Capture-Western; Reconstituted Complex
YWHAZRAF11118317628630 9261098 10611249 10620507 10887173 Affinity Capture-Western; Reconstituted Complex
YWHABRAF11118317644510 8702721 10620507 10848612 12360521 12620389 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABRAF11133617644510 8702721 10620507 10848612 12360521 12620389 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAERAF11133637644510 8702721 Affinity Capture-Western; Two-hybrid
YWHAERAF11118317644510 8702721 Affinity Capture-Western; Two-hybrid
RAP1ARAF11118317791872 7862125 9867809 10454553 Co-crystal Structure; Reconstituted Complex; Two-hybrid
RAP1ARAF11118417791872 7862125 9867809 10454553 Co-crystal Structure; Reconstituted Complex; Two-hybrid
YWHAQRAF11161688663231 10620507 10757792 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
YWHAQRAF11118318663231 10620507 10757792 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
YWHAHRAF11133658702721 10620507 11969417 Affinity Capture-Western
YWHAHRAF11118318702721 10620507 11969417 Affinity Capture-Western
VAV1RAF11118318900182 Affinity Capture-Western
VAV1RAF11132528900182 Affinity Capture-Western
RHEBRAF11118319001246 15150271 15854902 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RHEBRAF11119419001246 15150271 15854902 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1RAF11118319819434 10523633 15485920 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
RB1RAF11118609819434 10523633 15485920 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
RBL2RAF11118319819434 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RBL2RAF11118699819434 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAGRAF111183110433554 10620507 17353931 Affinity Capture-MS; Affinity Capture-Western
YWHAGRAF111336410433554 10620507 17353931 Affinity Capture-MS; Affinity Capture-Western
MRASRAF111648610498616 Reconstituted Complex
MRASRAF111183110498616 Reconstituted Complex
MAPK8IP3RAF111183110523642 11044439 Affinity Capture-Western; Reconstituted Complex
MAPK8IP3RAF111677410523642 11044439 Affinity Capture-Western; Reconstituted Complex
RRAS2RAF111648010557073 10783161 Reconstituted Complex; Two-hybrid
RRAS2RAF111183110557073 10783161 Reconstituted Complex; Two-hybrid
SHOC2RAF111372910783161 Affinity Capture-Western
SHOC2RAF111183110783161 Affinity Capture-Western
CFLARRAF111436410837247 16537561 Affinity Capture-Western
CFLARRAF111183110837247 16537561 Affinity Capture-Western
RRASRAF111183110848612 19805522 Affinity Capture-Western; Two-hybrid
RRASRAF111215110848612 19805522 Affinity Capture-Western; Two-hybrid
PRPF6RAF111729810848612 Two-hybrid
PRPF6RAF111183110848612 Two-hybrid
MST4RAF111972211306563 Two-hybrid
MST4RAF111183111306563 Two-hybrid
UBE2D2RAF111183111676916 Biochemical Activity
UBE2D2RAF111317011676916 Biochemical Activity
VDAC1RAF111183112079506 Affinity Capture-Western
VDAC1RAF111325912079506 Affinity Capture-Western
OIP5RAF111646712620389 Two-hybrid
OIP5RAF111183112620389 Two-hybrid
CCT3RAF111183112620389 Two-hybrid
CCT3RAF111305412620389 Two-hybrid
SPRY2RAF111554712717443 Affinity Capture-Western
SPRY2RAF111183112717443 Affinity Capture-Western
SPRY4RAF112359912717443 Affinity Capture-Western
SPRY4RAF111183112717443 Affinity Capture-Western
CNKSR2RAF111653414597674 Affinity Capture-Western
CNKSR2RAF111183114597674 Affinity Capture-Western
RASD2RAF111709514724584 Reconstituted Complex
RASD2RAF111183114724584 Reconstituted Complex
CNKSR1RAF111555015075335 Reconstituted Complex
CNKSR1RAF111183115075335 Reconstituted Complex
PEBP4RAF112759215302887 Affinity Capture-Western; Reconstituted Complex
PEBP4RAF111183115302887 Affinity Capture-Western; Reconstituted Complex
UBCRAF111183116504566 Affinity Capture-Western
UBCRAF111316416504566 Affinity Capture-Western
STUB1RAF111556319011619 Affinity Capture-Western; Reconstituted Complex
STUB1RAF111183119011619 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
RAF1EFEMP121768712620389 RAF1 (C-Raf) interacts with an unspecified isoform of EFEMP1 (FBNL).
RAF1HRAS21869115705808 Hras interacts with Raf. This interaction was modelled on a demonstrated interaction between Hras and Raf, both from an unspecified species.
RAF1PHB31250916041367 RAF1 (c-Raf) interacts with PHB.
RAF1PPP2R2B31250716041367 RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2B (PP2A-B).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97847
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090826-2'