AutismKB 2.0

Annotation Details for RAP1A


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Basic Information Top
Gene Symbol:RAP1A ( KREV-1,KREV1,RAP1,SMGP21 )
Gene Full Name: RAP1A, member of RAS oncogene family
Band: 1p13.2
Quick LinksEntrez ID:5906; OMIM: 179520; Uniprot ID:RAP1A_HUMAN; ENSEMBL ID: ENSG00000116473; HGNC ID: 9855
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm11359771
GO:0005769ISS-early endosome-
GO:0005770ISS-late endosome-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0030054ISS-cell junction-
GO:0032045IEA-guanyl-nucleotide exchange factor complex-
GO:0035579TAS-specific granule membrane-
GO:0043005IEA-neuron projection-
GO:0043209IEA-myelin sheath-
GO:0045335IEA-phagocytic vesicle-
GO:0048471IDA-perinuclear region of cytoplasm11359771
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0003924IEA-GTPase activity-
GO:0005515IPI-protein binding7791872
GO:0005525IEA-GTP binding-
GO:0008565IDA-protein transporter activity17916086
GO:0017016IEA-Ras GTPase binding-
GO:0017034ISS-Rap guanyl-nucleotide exchange factor activity-
GO:0032403IDA-protein complex binding17916086
GO ID Evidence Qualifier GO_term References
GO:0000186TAS-activation of MAPKK activity-
GO:0007165TAS-signal transduction2642744
GO:0010976ISS-positive regulation of neuron projection development-
GO:0015031IDA-protein transport17916086
GO:0030033IMPNOTmicrovillus assembly22797597
GO:0032486IMP-Rap protein signal transduction21840392
GO:0032966IEA-negative regulation of collagen biosynthetic process-
GO:0035690IEA-cellular response to drug-
GO:0038180ISS-nerve growth factor signaling pathway-
GO:0043312TAS-neutrophil degranulation-
GO:0043547ISS-positive regulation of GTPase activity-
GO:0045860ISS-positive regulation of protein kinase activity-
GO:0046326IEA-positive regulation of glucose import-
GO:0050796TAS-regulation of insulin secretion-
GO:0061028IMP-establishment of endothelial barrier21840392
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0071320IDA-cellular response to cAMP21840392
GO:0071333IEA-cellular response to glucose stimulus-
GO:0097327IEA-response to antineoplastic agent-
GO:0097421IEA-liver regeneration-
GO:1901888IMP-regulation of cell junction assembly21840392
GO:1905451IEA-positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:1990090ISS-cellular response to nerve growth factor stimulus-
GO:2000301IEA-negative regulation of synaptic vesicle exocytosis-
GO:2001214ISS-positive regulation of vasculogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAP1ABRAF10714110454553 Reconstituted Complex
RAP1ABRAF11184110454553 Reconstituted Complex
RAP1AKRIT11118419285558 Two-hybrid
RAP1AKRIT11073309285558 Two-hybrid
RAP1AMTOR11184115854902 Affinity Capture-Western
RAP1AMTOR10875715854902 Affinity Capture-Western
RAP1AMLLT411044710922060 Reconstituted Complex; Two-hybrid
RAP1AMLLT411184110922060 Reconstituted Complex; Two-hybrid
RAP1ANTRK111096911466412 Affinity Capture-Western
RAP1ANTRK111184111466412 Affinity Capture-Western
RAP1APDE6D11184111786539 11980706 Two-hybrid
RAP1APDE6D11117311786539 11980706 Two-hybrid
RAP1ARAF11118317791872 7862125 9867809 10454553 Co-crystal Structure; Reconstituted Complex; Two-hybrid
RAP1ARAF11118417791872 7862125 9867809 10454553 Co-crystal Structure; Reconstituted Complex; Two-hybrid
RAP1ARALA11184111786539 Two-hybrid
RAP1ARALA11183411786539 Two-hybrid
RAP1ARALGDS11184110085114 10922060 Reconstituted Complex; Two-hybrid
RAP1ARALGDS11183610085114 10922060 Reconstituted Complex; Two-hybrid
RUNDC3ARAP1A1118419523700 Reconstituted Complex
RUNDC3ARAP1A1161069523700 Reconstituted Complex
RAPGEF3RAP1A11184110777494 Biochemical Activity
RAPGEF3RAP1A11568210777494 Biochemical Activity
RAPGEF4RAP1A11625310777494 Biochemical Activity
RAPGEF4RAP1A11184110777494 Biochemical Activity
RAPGEF5RAP1A11184110777494 10934204 Biochemical Activity
RAPGEF5RAP1A11511610777494 10934204 Biochemical Activity
RGS14RAP1A11184110926822 Reconstituted Complex
RGS14RAP1A11588010926822 Reconstituted Complex
RAPGEF2RAP1A11504510934204 Biochemical Activity; Reconstituted Complex
RAPGEF2RAP1A11184110934204 Biochemical Activity; Reconstituted Complex
RAPGEF6RAP1A11184111524421 Biochemical Activity
RAPGEF6RAP1A11970511524421 Biochemical Activity
RAP1GDS1RAP1A11184111948427 Two-hybrid
RAP1GDS1RAP1A11184511948427 Two-hybrid
TSC2RAP1A11310012147258 12842888 Affinity Capture-Western; Co-purification
TSC2RAP1A11184112147258 12842888 Affinity Capture-Western; Co-purification
GABARAPL2RAP1A11647312581858 Biochemical Activity
GABARAPL2RAP1A11184112581858 Biochemical Activity
ARHGEF1RAP1A11458512581858 Biochemical Activity
ARHGEF1RAP1A11184112581858 Biochemical Activity
RAP1GAPRAP1A11184112842888 Biochemical Activity
RAP1GAPRAP1A11184412842888 Biochemical Activity
RGL4RAP1A11184112874025 Reconstituted Complex
RGL4RAP1A12933612874025 Reconstituted Complex
RHEBRAP1A11184115854902 Affinity Capture-Western
RHEBRAP1A11194115854902 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
RAP1ARAPGEF131244615856025 Rap1A interacts with an unspecified isoform of C3G.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97852
  • Data Attributes: MGI curated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040625-167'