AutismKB 2.0

Annotation Details for RAP1GAP


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Basic Information Top
Gene Symbol:RAP1GAP ( KIAA0474,RAP1GA1,RAP1GAP1,RAP1GAPII,RAPGAP )
Gene Full Name: RAP1 GTPase activating protein
Band: 1p36.12
Quick LinksEntrez ID:5909; OMIM: 600278; Uniprot ID:RPGP1_HUMAN; ENSEMBL ID: ENSG00000076864; HGNC ID: 9858
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005829IDA-cytosol10476970
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane10476970
GO ID Evidence Qualifier GO_term References
GO:0003924NAS-GTPase activity10476970
GO:0005096EXP-GTPase activator activity16076873
GO:0005096IDA-GTPase activator activity15141215
GO:0005515IPI-protein binding18309292
GO:0017016IPI-Ras GTPase binding18309292
GO:0042803IPI-protein homodimerization activity18309292
GO ID Evidence Qualifier GO_term References
GO:0007165NAS-signal transduction10476970
GO:0007411TAS-axon guidance-
GO:0043087IDA-regulation of GTPase activity18309292
GO:0043547IDA-positive regulation of GTPase activity15141215
GO:0051056IEA-regulation of small GTPase mediated signal transduction-
GO:1903697IMP-negative regulation of microvillus assembly22797597
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAP1GAPBRAF10714111278445 Reconstituted Complex
RAP1GAPBRAF11184411278445 Reconstituted Complex
RAP1GAPGNAZ10904310593970 Reconstituted Complex
RAP1GAPGNAZ11184410593970 Reconstituted Complex
RAP1GAPMLLT411044712590145 Affinity Capture-Western; Two-hybrid
RAP1GAPMLLT411184412590145 Affinity Capture-Western; Two-hybrid
RAP1GAPPFN211123816169070 Two-hybrid
RAP1GAPPFN211184416169070 Two-hybrid
RAP1GAPRAP1A11184112842888 Biochemical Activity
RAP1GAPRAP1A11184412842888 Biochemical Activity
MEX3BRAP1GAP12394516169070 Two-hybrid
MEX3BRAP1GAP11184416169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109338
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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