AutismKB 2.0

Annotation Details for RARA


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Basic Information Top
Gene Symbol:RARA ( NR1B1,RAR )
Gene Full Name: retinoic acid receptor, alpha
Band: 17q21.2
Quick LinksEntrez ID:5914; OMIM: 180240; Uniprot ID:RARA_HUMAN; ENSEMBL ID: ENSG00000131759; HGNC ID: 9864
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin17363140
GO:0005634IDA-nucleus18845237
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm19850744
GO:0005829IDA-cytosol-
GO:0009986IC-cell surface2825025
GO:0015629IDA-actin cytoskeleton-
GO:0030425IEA-dendrite-
GO:0043025IEA-neuronal cell body-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000900IEA-translation repressor activity, nucleic acid binding-
GO:0000977IEA-RNA polymerase II regulatory region sequence-specific DNA binding-
GO:0001972IDA-retinoic acid binding2825025
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding18922886
GO:0003707IEA-steroid hormone receptor activity-
GO:0003708IDA-retinoic acid receptor activity2825025
GO:0003713IDA-transcription coactivator activity2825025
GO:0003713IMP-transcription coactivator activity19917671
GO:0003714IDA-transcription corepressor activity20080953
GO:0005102IDA-receptor binding19628791
GO:0005515IPI-protein binding9653119
GO:0008134IPI-transcription factor binding17641689
GO:0008144IEA-drug binding-
GO:0008270IEA-zinc ion binding-
GO:0019899IPI-enzyme binding9628876
GO:0019904IPI-protein domain specific binding20413580
GO:0031490IDA-chromatin DNA binding19917671
GO:0042826IEA-histone deacetylase binding-
GO:0043422IPI-protein kinase B binding16417524
GO:0044323IDA-retinoic acid-responsive element binding19917671
GO:0046982IDA-protein heterodimerization activity19917671
GO:0048027IEA-mRNA 5'-UTR binding-
GO:0051018IDA-protein kinase A binding20215566
GO:0051393IPI-alpha-actinin binding22351778
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001657IEA-ureteric bud development-
GO:0001843IEA-neural tube closure-
GO:0001889IEA-liver development-
GO:0002068IEA-glandular epithelial cell development-
GO:0003148IEA-outflow tract septum morphogenesis-
GO:0003417IEA-growth plate cartilage development-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006468IMP-protein phosphorylation16456540
GO:0007165IDA-signal transduction2825025
GO:0007281IEA-germ cell development-
GO:0007283IEA-spermatogenesis-
GO:0007565IEA-female pregnancy-
GO:0008284IMP-positive regulation of cell proliferation20080953
GO:0008285IEA-negative regulation of cell proliferation-
GO:0021766IEA-hippocampus development-
GO:0030850IEA-prostate gland development-
GO:0030853IDA-negative regulation of granulocyte differentiation19917671
GO:0031076IEA-embryonic camera-type eye development-
GO:0031641IEA-regulation of myelination-
GO:0032355IEA-response to estradiol-
GO:0032526IMP-response to retinoic acid17538076
GO:0032689IDA-negative regulation of interferon-gamma production18416830
GO:0032720IDA-negative regulation of tumor necrosis factor production18416830
GO:0032736IDA-positive regulation of interleukin-13 production18416830
GO:0032753IDA-positive regulation of interleukin-4 production18416830
GO:0032754IDA-positive regulation of interleukin-5 production18416830
GO:0033189IEA-response to vitamin A-
GO:0034097IEA-response to cytokine-
GO:0035264IEA-multicellular organism growth-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043277IMP-apoptotic cell clearance19628791
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0045471IEA-response to ethanol-
GO:0045630IDA-positive regulation of T-helper 2 cell differentiation18416830
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0045787IMP-positive regulation of cell cycle20080953
GO:0045892IDA-negative regulation of transcription, DNA-templated20080953
GO:0045893IDA-positive regulation of transcription, DNA-templated18845237
GO:0045893IMP-positive regulation of transcription, DNA-templated19628791
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter19850744
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter20080953
GO:0045947IEA-negative regulation of translational initiation-
GO:0048167IEA-regulation of synaptic plasticity-
GO:0048384IMP-retinoic acid receptor signaling pathway17538076
GO:0051099IMP-positive regulation of binding20080953
GO:0055012IEA-ventricular cardiac muscle cell differentiation-
GO:0060010IEA-Sertoli cell fate commitment-
GO:0060173IEA-limb development-
GO:0060324IEA-face development-
GO:0060534IEA-trachea cartilage development-
GO:0060591IEA-chondroblast differentiation-
GO:0061037IEA-negative regulation of cartilage development-
GO:0071222IEA-cellular response to lipopolysaccharide-
GO:0071300IDA-cellular response to retinoic acid19917671
GO:0071391IDA-cellular response to estrogen stimulus20080953
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RARAPARP111184915808511 Affinity Capture-Western
RARAPARP110665215808511 Affinity Capture-Western
RARAARNTL11184911439184 Reconstituted Complex
RARAARNTL10689911439184 Reconstituted Complex
RARABAG11118499642262 Reconstituted Complex; Two-hybrid
RARABAG11070499642262 Reconstituted Complex; Two-hybrid
RARAKLF511184921383775 Affinity Capture-Western
RARAKLF510715321383775 Affinity Capture-Western
RARARUNX111184918073335 Affinity Capture-Western
RARARUNX110730918073335 Affinity Capture-Western
RARACCND311184912482873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RARACCND310733612482873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RARACREBBP11184917475621 Affinity Capture-Western
RARACREBBP10777717475621 Affinity Capture-Western
RARAGADD45A11184910872826 Affinity Capture-Western
RARAGADD45A10801410872826 Affinity Capture-Western
RARAEP30010834711980644 17475621 Affinity Capture-Western
RARAEP30011184911980644 17475621 Affinity Capture-Western
RARAHDAC210931618073335 21383775 Affinity Capture-Western; Co-localization
RARAHDAC211184918073335 21383775 Affinity Capture-Western; Co-localization
RARAHMGA111184910428834 Reconstituted Complex; Two-hybrid
RARAHMGA110940210428834 Reconstituted Complex; Two-hybrid
RARAHNRNPU11184918212063 Affinity Capture-MS
RARAHNRNPU10943318212063 Affinity Capture-MS
RARANPAS211092311439184 Reconstituted Complex; Two-hybrid
RARANPAS211184911439184 Reconstituted Complex; Two-hybrid
RARANPM111184918212063 Affinity Capture-MS
RARANPM111092918212063 Affinity Capture-MS
RARANR4A21118497705655 Reconstituted Complex; Two-hybrid
RARANR4A21109837705655 Reconstituted Complex; Two-hybrid
RARAPIN111184915670742 Reconstituted Complex
RARAPIN111131715670742 Reconstituted Complex
RARAPML11138410610177 10882117 18073335 Affinity Capture-Western; Co-purification; Reconstituted Complex
RARAPML11184910610177 10882117 18073335 Affinity Capture-Western; Co-purification; Reconstituted Complex
RARAPOU2F111144710480874 Reconstituted Complex
RARAPOU2F111184910480874 Reconstituted Complex
RARAMED111146510760302 Affinity Capture-Western; FRET; Reconstituted Complex
RARAMED111184910760302 Affinity Capture-Western; FRET; Reconstituted Complex
RARAPSMC511167812503607 Reconstituted Complex
RARAPSMC511184912503607 Reconstituted Complex
RXRARARA1118491314167 9415406 12052862 15171703 15528208 Affinity Capture-Western; Co-crystal Structure; Co-purification; Far Western; Reconstituted Complex
RXRARARA1121681314167 9415406 12052862 15171703 15528208 Affinity Capture-Western; Co-crystal Structure; Co-purification; Far Western; Reconstituted Complex
NR0B2RARA1140128650544 9773978 Reconstituted Complex; Two-hybrid
NR0B2RARA1118498650544 9773978 Reconstituted Complex; Two-hybrid
NRIP1RARA1138438887632 10082574 12503607 12549917 14581481 Affinity Capture-Western; Reconstituted Complex
NRIP1RARA1118498887632 10082574 12503607 12549917 14581481 Affinity Capture-Western; Reconstituted Complex
TRIM24RARA1143339115274 12503607 Reconstituted Complex
TRIM24RARA1118499115274 12503607 Reconstituted Complex
NCOA1RARA1142009192892 10082574 10760302 17475621 Affinity Capture-Western; FRET; Reconstituted Complex
NCOA1RARA1118499192892 10082574 10760302 17475621 Affinity Capture-Western; FRET; Reconstituted Complex
NCOA2RARA1157619192892 12503607 12612084 Reconstituted Complex; Two-hybrid
NCOA2RARA1118499192892 12503607 12612084 Reconstituted Complex; Two-hybrid
NCOA3RARA1138419192892 17475621 Reconstituted Complex; Two-hybrid
NCOA3RARA1118499192892 17475621 Reconstituted Complex; Two-hybrid
NCOR2RARA1149749256429 9415406 10082574 11929748 17475621 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
NCOR2RARA1118499256429 9415406 10082574 11929748 17475621 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
KAT2BRARA1143759445475 14581481 17475621 Affinity Capture-Western
KAT2BRARA1118499445475 14581481 17475621 Affinity Capture-Western
NCOR1RARA1149739486655 9531570 10336495 10882117 15336696 18978041 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR1RARA1118499486655 9531570 10336495 10882117 15336696 18978041 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MECRRARA1192919795230 Two-hybrid
MECRRARA1118499795230 Two-hybrid
SP1RARA11255010361124 18270252 19401466 Affinity Capture-Western; Co-localization; Reconstituted Complex
SP1RARA11184910361124 18270252 19401466 Affinity Capture-Western; Co-localization; Reconstituted Complex
TRIP4RARA11473510454579 Reconstituted Complex
TRIP4RARA11184910454579 Reconstituted Complex
SRCRARA11259210454579 12612084 Reconstituted Complex; Two-hybrid
SRCRARA11184910454579 12612084 Reconstituted Complex; Two-hybrid
NCOA6RARA11669110567404 10823961 11158331 Reconstituted Complex; Two-hybrid
NCOA6RARA11184910567404 10823961 11158331 Reconstituted Complex; Two-hybrid
NR2E3RARA11532010611353 Reconstituted Complex
NR2E3RARA11184910611353 Reconstituted Complex
NKX2-1RARA11293610617585 Two-hybrid
NKX2-1RARA11184910617585 Two-hybrid
NRBF2RARA11900910786636 Two-hybrid
NRBF2RARA11184910786636 Two-hybrid
GADD45GRARA11611710872826 Reconstituted Complex
GADD45GRARA11184910872826 Reconstituted Complex
KDM5ARARA11186211358960 Reconstituted Complex
KDM5ARARA11184911358960 Reconstituted Complex
IRX4RARA11912511382777 Reconstituted Complex; Two-hybrid
IRX4RARA11184911382777 Reconstituted Complex; Two-hybrid
CLOCKRARA11494411439184 Reconstituted Complex; Two-hybrid
CLOCKRARA11184911439184 Reconstituted Complex; Two-hybrid
TADA3RARA11573712235159 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
TADA3RARA11184912235159 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
TDGRARA11184912874288 Reconstituted Complex
TDGRARA11285512874288 Reconstituted Complex
HDAC3RARA11436812943985 Reconstituted Complex
HDAC3RARA11184912943985 Reconstituted Complex
HDAC4RARA11184912943985 Reconstituted Complex
HDAC4RARA11510612943985 Reconstituted Complex
RARARARA11184914521715 18073335 Affinity Capture-Western; Reconstituted Complex
ZBTB16RARA11349814521715 Reconstituted Complex; Two-hybrid
ZBTB16RARA11184914521715 Reconstituted Complex; Two-hybrid
UBCRARA11316415171703 Affinity Capture-Western
UBCRARA11184915171703 Affinity Capture-Western
SUMO1RARA11318815171703 Affinity Capture-Western
SUMO1RARA11184915171703 Affinity Capture-Western
MED6RARA11531915808511 Affinity Capture-Western
MED6RARA11184915808511 Affinity Capture-Western
RXRBRARA11184916189514 Two-hybrid
RXRBRARA11216916189514 Two-hybrid
RXRGRARA11217016189514 Two-hybrid
RXRGRARA11184916189514 Two-hybrid
SKIRARA11238816424870 19341714 Affinity Capture-Western; Co-localization
SKIRARA11184916424870 19341714 Affinity Capture-Western; Co-localization
SUV39H1RARA11270616449642 Affinity Capture-Western
SUV39H1RARA11184916449642 Affinity Capture-Western
C1orf103RARA12090517455211 Far Western; Reconstituted Complex; Two-hybrid
C1orf103RARA11184917455211 Far Western; Reconstituted Complex; Two-hybrid
SIAH1RARA11237218073335 Affinity Capture-Western
SIAH1RARA11184918073335 Affinity Capture-Western
RUVBL1RARA11416618087039 Affinity Capture-Western
RUVBL1RARA11184918087039 Affinity Capture-Western
MRTO4RARA11933718212063 Affinity Capture-MS
MRTO4RARA11184918212063 Affinity Capture-MS
RFC4RARA11184918212063 Affinity Capture-MS
RFC4RARA11191618212063 Affinity Capture-MS
SAP130RARA12273518212063 Affinity Capture-MS
SAP130RARA11184918212063 Affinity Capture-MS
SNRNP40RARA11480518212063 Affinity Capture-MS
SNRNP40RARA11184918212063 Affinity Capture-MS
TOP2BRARA11300818212063 Affinity Capture-MS; Reconstituted Complex
TOP2BRARA11184918212063 Affinity Capture-MS; Reconstituted Complex
WTIPRARA12598520133701 Affinity Capture-Western
WTIPRARA11184920133701 Affinity Capture-Western
LIMD1RARA11447520133701 Affinity Capture-Western
LIMD1RARA11184920133701 Affinity Capture-Western
JUBRARA12439320133701 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
JUBRARA11184920133701 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
HRRARA11184920211142 Two-hybrid
HRRARA12091720211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97856
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-284'