AutismKB 2.0

Annotation Details for RB1


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Basic Information Top
Gene Symbol:RB1 ( OSRC,RB,p105-Rb,pRb,pp110 )
Gene Full Name: retinoblastoma 1
Band: 13q14.2
Quick LinksEntrez ID:5925; OMIM: 180200; Uniprot ID:RB_HUMAN; ENSEMBL ID: ENSG00000139687; HGNC ID: 9884
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000785TAS-chromatin3657987
GO:0005634IDA-nucleus17540172
GO:0005634NAS-nucleus2730637
GO:0005654IDA-nucleoplasm8245034
GO:0005654TAS-nucleoplasm-
GO:0005819IEA-spindle-
GO:0008024IDAcolocalizes_withcyclin/CDK positive transcription elongation factor complex12037672
GO:0016514TAS-SWI/SNF complex19149898
GO:0016605IDA-PML body9448006
GO:0035189IDA-Rb-E2F complex8245034
GO:0035189TAS-Rb-E2F complex19149898
GO ID Evidence Qualifier GO_term References
GO:0001047IDA-core promoter binding15735762
GO:0001102IEA-RNA polymerase II activating transcription factor binding-
GO:0003674ND-molecular_function-
GO:0003677TAS-DNA binding3657987
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding3657987
GO:0003713NAS-transcription coactivator activity15572661
GO:0005515IPI-protein binding1331501
GO:0008134IPI-transcription factor binding16360038
GO:0019900IDA-kinase binding16286473
GO:0031625IPI-ubiquitin protein ligase binding10944455
GO:0042802IPI-identical protein binding8288605
GO:0050681NAS-androgen receptor binding15572661
GO:0051219IPI-phosphoprotein binding16360038
GO:0061676IPI-importin-alpha family protein binding12695505
GO:0097718IPI-disordered domain specific binding8245034
GO ID Evidence Qualifier GO_term References
GO:0000075TAS-cell cycle checkpoint10825186
GO:0000082TAS-G1/S transition of mitotic cell cycle-
GO:0000083TAS-regulation of transcription involved in G1/S transition of mitotic cell cycle19149898
GO:0001558IEA-regulation of cell growth-
GO:0001894IEA-tissue homeostasis-
GO:0006338TAS-chromatin remodeling19149898
GO:0006351IEA-transcription, DNA-templated-
GO:0006355NAS-regulation of transcription, DNA-templated2730637
GO:0006469IPI-negative regulation of protein kinase activity9858607
GO:0007050TAS-cell cycle arrest19149898
GO:0007070TAS-negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle19149898
GO:0007093TAS-mitotic cell cycle checkpoint9529249
GO:0007265IEP-Ras protein signal transduction9054499
GO:0007346IMP-regulation of mitotic cell cycle20551165
GO:0010629IMP-negative regulation of gene expression25100735
GO:0016032IEA-viral process-
GO:0016569IEA-covalent chromatin modification-
GO:0030521NAS-androgen receptor signaling pathway15572661
GO:0031134IMP-sister chromatid biorientation20551165
GO:0031175IEA-neuron projection development-
GO:0034088IMP-maintenance of mitotic sister chromatid cohesion20551165
GO:0034349IEA-glial cell apoptotic process-
GO:0035914IEA-skeletal muscle cell differentiation-
GO:0042551IEA-neuron maturation-
GO:0043353IEA-enucleate erythrocyte differentiation-
GO:0043433TAS-negative regulation of sequence-specific DNA binding transcription factor activity9529249
GO:0043550IDA-regulation of lipid kinase activity16286473
GO:0045445IMP-myoblast differentiation15541338
GO:0045651IEA-positive regulation of macrophage differentiation-
GO:0045842IMP-positive regulation of mitotic metaphase/anaphase transition20551165
GO:0045879IEA-negative regulation of smoothened signaling pathway-
GO:0045892IDA-negative regulation of transcription, DNA-templated10783144
GO:0045892TAS-negative regulation of transcription, DNA-templated19149898
GO:0045893NAS-positive regulation of transcription, DNA-templated15572661
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048565IEA-digestive tract development-
GO:0048667IEA-cell morphogenesis involved in neuron differentiation-
GO:0050680IEA-negative regulation of epithelial cell proliferation-
GO:0051146IEA-striated muscle cell differentiation-
GO:0051301IEA-cell division-
GO:0051402IEA-neuron apoptotic process-
GO:0071459IMP-protein localization to chromosome, centromeric region20551165
GO:0071466IEA-cellular response to xenobiotic stimulus-
GO:0071922IMP-regulation of cohesin loading20551165
GO:0071930IEA-negative regulation of transcription involved in G1/S transition of mitotic cell cycle-
GO:0090230TAS-regulation of centromere complex assembly20551165
GO:0097284IEA-hepatocyte apoptotic process-
GO:2000134TAS-negative regulation of G1/S transition of mitotic cell cycle19149898
GO:2000679IDA-positive regulation of transcription regulatory region DNA binding25100735
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RB1ABL11065438242749 9071815 Affinity Capture-Western; Reconstituted Complex
RB1ABL11118608242749 9071815 Affinity Capture-Western; Reconstituted Complex
RB1AHR1066999712901 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1AHR1118609712901 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1AR1118609675141 9813067 16964284 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1AR1068629675141 9813067 16964284 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1ARNT1068989712901 Affinity Capture-Western
RB1ARNT1118609712901 Affinity Capture-Western
RB1BAG110704912845674 Affinity Capture-Western
RB1BAG111186012845674 Affinity Capture-Western
RB1CCND11070678490963 11126356 11593423 15485920 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex
RB1CCND11118608490963 11126356 11593423 15485920 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex
RB1BCR1070839071815 Affinity Capture-Western
RB1BCR1118609071815 Affinity Capture-Western
RB1BRCA110714010220405 10518542 11521194 Affinity Capture-Western; Co-localization; Reconstituted Complex
RB1BRCA111186010220405 10518542 11521194 Affinity Capture-Western; Co-localization; Reconstituted Complex
RB1CCND311186017972097 Two-hybrid
RB1CCND310733617972097 Two-hybrid
RB1CCNT210734412037672 Reconstituted Complex
RB1CCNT211186012037672 Reconstituted Complex
RB1CDK210745210938106 15003538 19225156 Biochemical Activity
RB1CDK211186010938106 15003538 19225156 Biochemical Activity
RB1CDK410745415003538 19225156 Biochemical Activity
RB1CDK411186015003538 19225156 Biochemical Activity
RB1CDK910745912037672 Affinity Capture-Western; Reconstituted Complex
RB1CDK911186012037672 Affinity Capture-Western; Reconstituted Complex
RB1CEBPB11186011596110 Reconstituted Complex
RB1CEBPB10748011596110 Reconstituted Complex
RB1ATF21118601641004 Reconstituted Complex
RB1ATF21077761641004 Reconstituted Complex
RB1CUX111186012891711 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1CUX110790312891711 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1DNMT110812310888886 11847125 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RB1DNMT111186010888886 11847125 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RB1DNMT3A11186011350943 Reconstituted Complex
RB1DNMT3A10812511350943 Reconstituted Complex
RB1E2F11082017739537 8230483 8896460 9422723 10869426 11470869 11839806 12397079 12963846 15485920 15670817 16766265 18216119 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1E2F11118607739537 8230483 8896460 9422723 10869426 11470869 11839806 12397079 12963846 15485920 15670817 16766265 18216119 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1E2F210820212502741 Co-crystal Structure; Reconstituted Complex
RB1E2F211186012502741 Co-crystal Structure; Reconstituted Complex
RB1E2F41082069858615 10869426 Affinity Capture-Western; Two-hybrid
RB1E2F41118609858615 10869426 Affinity Capture-Western; Two-hybrid
RB1E4F110820910869426 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1E4F111186010869426 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1FOXM111186015024056 Affinity Capture-Western
RB1FOXM110859415024056 Affinity Capture-Western
RB1FRK1087267664264 Affinity Capture-Western; Reconstituted Complex
RB1FRK1118607664264 Affinity Capture-Western; Reconstituted Complex
RB1BRF111186010330166 11997511 Affinity Capture-Western; Reconstituted Complex
RB1BRF110922710330166 11997511 Affinity Capture-Western; Reconstituted Complex
RB1HDAC11093159468139 9468140 9491888 9724731 9988677 10490602 10615135 10778858 10779361 10958676 11158299 11583987 11684023 11839806 12466959 12473678 15003538 15044952 15485920 16766265 17827154 19081374 Affinity Capture-Western; Reconstituted Complex
RB1HDAC11118609468139 9468140 9491888 9724731 9988677 10490602 10615135 10778858 10779361 10958676 11158299 11583987 11684023 11839806 12466959 12473678 15003538 15044952 15485920 16766265 17827154 19081374 Affinity Capture-Western; Reconstituted Complex
RB1HDAC210931610490602 11583987 11593423 17827154 Affinity Capture-Western; Reconstituted Complex
RB1HDAC211186010490602 11583987 11593423 17827154 Affinity Capture-Western; Reconstituted Complex
RB1HMGB111186011748221 Reconstituted Complex
RB1HMGB110938911748221 Reconstituted Complex
RB1JUN10992810026157 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1JUN11186010026157 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1LMNA1118608278403 Reconstituted Complex
RB1LMNA1101868278403 Reconstituted Complex
RB1MCM71118609566894 16912045 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1MCM71103449566894 16912045 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1MDM211186010078201 15044952 Affinity Capture-Western; Reconstituted Complex
RB1MDM211035810078201 15044952 Affinity Capture-Western; Reconstituted Complex
RB1MNAT111186011113200 Reconstituted Complex
RB1MNAT111047411113200 Reconstituted Complex
RB1MYC1118607838535 Two-hybrid
RB1MYC1106947838535 Two-hybrid
RB1MYOD11107378381715 11285237 Affinity Capture-Western; Reconstituted Complex
RB1MYOD11118608381715 11285237 Affinity Capture-Western; Reconstituted Complex
RB1NFIX11085611896613 Affinity Capture-Western
RB1NFIX11186011896613 Affinity Capture-Western
RB1PA2G411107511268000 Affinity Capture-Western; Reconstituted Complex
RB1PA2G411186011268000 Affinity Capture-Western; Reconstituted Complex
RB1SERPINB211109212944478 16397580 Affinity Capture-Western; Reconstituted Complex
RB1SERPINB211186012944478 16397580 Affinity Capture-Western; Reconstituted Complex
RB1PAX611111410359315 Reconstituted Complex
RB1PAX611186010359315 Reconstituted Complex
RB1PHB11126410376528 10523633 16964284 Affinity Capture-Western; Reconstituted Complex
RB1PHB11186010376528 10523633 16964284 Affinity Capture-Western; Reconstituted Complex
RB1PML1113849448006 Affinity Capture-Western; Reconstituted Complex
RB1PML1118609448006 Affinity Capture-Western; Reconstituted Complex
RB1POLA11114189395244 Affinity Capture-Western; Co-purification
RB1POLA11118609395244 Affinity Capture-Western; Co-purification
RB1PPA111146017008050 Affinity Capture-Western
RB1PPA111186017008050 Affinity Capture-Western
RB1PPARG11146412479814 Affinity Capture-Western; Reconstituted Complex
RB1PPARG11186012479814 Affinity Capture-Western; Reconstituted Complex
RB1RAF11118319819434 10523633 15485920 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
RB1RAF11118609819434 10523633 15485920 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
RBBP4RB11118637503932 10734134 11283269 11470869 Affinity Capture-Western; Reconstituted Complex
RBBP4RB11118607503932 10734134 11283269 11470869 Affinity Capture-Western; Reconstituted Complex
RBBP7RB11118667503932 10220405 11283269 Affinity Capture-Western; Reconstituted Complex
RBBP7RB11118607503932 10220405 11283269 Affinity Capture-Western; Reconstituted Complex
THOC1RB11153057525595 Reconstituted Complex; Two-hybrid
THOC1RB11118607525595 Reconstituted Complex; Two-hybrid
PRDM2RB11135757538672 Affinity Capture-Western; Reconstituted Complex
PRDM2RB11118607538672 Affinity Capture-Western; Reconstituted Complex
RBBP5RB11118607558034 Reconstituted Complex
RBBP5RB11118647558034 Reconstituted Complex
TAF1RB11127357724524 9242374 9858607 11126356 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
TAF1RB11118607724524 9242374 9858607 11126356 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
TFDP1RB11128857739537 Affinity Capture-Western
TFDP1RB11118607739537 Affinity Capture-Western
TFDP2RB11128877739537 Affinity Capture-Western
TFDP2RB11118607739537 Affinity Capture-Western
SMARCA4RB11124817923370 9128241 10778858 15485920 17666433 19081374 Affinity Capture-Western; Co-fractionation
SMARCA4RB11118607923370 9128241 10778858 15485920 17666433 19081374 Affinity Capture-Western; Co-fractionation
KDM5ARB11118627935440 11358960 Affinity Capture-Western; Reconstituted Complex
KDM5ARB11118607935440 11358960 Affinity Capture-Western; Reconstituted Complex
TRAP1RB11154358756626 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAP1RB11118608756626 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRKRARB11141439010216 Affinity Capture-Western; Reconstituted Complex
PRKRARB11118609010216 Affinity Capture-Western; Reconstituted Complex
HBP1RB11179279178770 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HBP1RB11118609178770 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TBPRB11118609242374 Reconstituted Complex
TBPRB11127719242374 Reconstituted Complex
TRIP11RB11147329256431 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRIP11RB11118609256431 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGM2RB11129109315663 Affinity Capture-Western
TGM2RB11118609315663 Affinity Capture-Western
ENC1RB11140799566959 Affinity Capture-Western; Reconstituted Complex
ENC1RB11118609566959 Affinity Capture-Western; Reconstituted Complex
RBBP9RB11159649697699 Affinity Capture-Western; Two-hybrid
RBBP9RB11118609697699 Affinity Capture-Western; Two-hybrid
CREG1RB11143329710587 Reconstituted Complex
CREG1RB11118609710587 Reconstituted Complex
RBBP8RB11118679721205 10779361 16581787 Affinity Capture-Western; Two-hybrid
RBBP8RB11118609721205 10779361 16581787 Affinity Capture-Western; Two-hybrid
SKIRB11123889988677 Affinity Capture-Western
SKIRB11118609988677 Affinity Capture-Western
SKILRB11123899988677 Affinity Capture-Western
SKILRB11118609988677 Affinity Capture-Western
CCNA1RB111441710022926 Affinity Capture-Western; Reconstituted Complex
CCNA1RB111186010022926 Affinity Capture-Western; Reconstituted Complex
RFC1RB111191310353443 Affinity Capture-Western
RFC1RB111186010353443 Affinity Capture-Western
ARID3BRB111186010446990 Reconstituted Complex
ARID3BRB111586510446990 Reconstituted Complex
ARID4ARB111186110490602 11283269 Affinity Capture-Western
ARID4ARB111186010490602 11283269 Affinity Capture-Western
RBL1RB111186810490602 Affinity Capture-Western
RBL1RB111186010490602 Affinity Capture-Western
RBL2RB111186910490602 Affinity Capture-Western
RBL2RB111186010490602 Affinity Capture-Western
HDAC3RB111436810490602 10958676 12479814 Affinity Capture-Western
HDAC3RB111186010490602 10958676 12479814 Affinity Capture-Western
AATFRB111186010783144 12450794 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AATFRB111774310783144 12450794 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBTFRB111319011042686 Affinity Capture-Western; Reconstituted Complex
UBTFRB111186011042686 Affinity Capture-Western; Reconstituted Complex
EID1RB111724311073989 11073990 11964378 15044952 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EID1RB111186011073989 11073990 11964378 15044952 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SNAPC1RB111250111094070 Affinity Capture-Western; Reconstituted Complex
SNAPC1RB111186011094070 Affinity Capture-Western; Reconstituted Complex
SNAPC3RB111250311094070 Reconstituted Complex
SNAPC3RB111186011094070 Reconstituted Complex
SP1RB111255011158299 11896613 Affinity Capture-Western
SP1RB111186011158299 11896613 Affinity Capture-Western
VDRRB111326411358960 Reconstituted Complex
VDRRB111186011358960 Reconstituted Complex
CBX5RB111703011484059 15485920 Affinity Capture-Western
CBX5RB111186011484059 15485920 Affinity Capture-Western
SUV39H1RB111270611484059 11533237 Affinity Capture-Western; Reconstituted Complex
SUV39H1RB111186011484059 11533237 Affinity Capture-Western; Reconstituted Complex
MRFAP1RB112503911500496 12397079 Affinity Capture-Western; Co-purification
MRFAP1RB111186011500496 12397079 Affinity Capture-Western; Co-purification
MORF4L1RB111613411500496 12397079 Affinity Capture-Western; Co-purification; Reconstituted Complex
MORF4L1RB111186011500496 12397079 Affinity Capture-Western; Co-purification; Reconstituted Complex
USP4RB111186011571651 11571652 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
USP4RB111322111571651 11571652 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RING1RB111194711583618 Affinity Capture-Western
RING1RB111186011583618 Affinity Capture-Western
CBX4RB111410511583618 Affinity Capture-Western; Phenotypic Enhancement
CBX4RB111186011583618 Affinity Capture-Western; Phenotypic Enhancement
SNW1RB111659712466551 Reconstituted Complex
SNW1RB111186012466551 Reconstituted Complex
TMPORB111186012475961 Affinity Capture-Western
TMPORB111296712475961 Affinity Capture-Western
PIK3R3RB111407512588990 Affinity Capture-Western; Reconstituted Complex
PIK3R3RB111186012588990 Affinity Capture-Western; Reconstituted Complex
PELP1RB111186012682072 Affinity Capture-Western; Reconstituted Complex
PELP1RB111797312682072 Affinity Capture-Western; Reconstituted Complex
CBX1RB111186012711675 Reconstituted Complex
CBX1RB111615112711675 Reconstituted Complex
GNB2L1RB111186012761493 Affinity Capture-Western
GNB2L1RB111567112761493 Affinity Capture-Western
TP73RB111301412761493 Affinity Capture-Western
TP73RB111186012761493 Affinity Capture-Western
MORF4L2RB111186014506250 Reconstituted Complex
MORF4L2RB111500114506250 Reconstituted Complex
NCOA6RB111669114645241 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA6RB111186014645241 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KAT2BRB111437515044952 Affinity Capture-Western; Reconstituted Complex
KAT2BRB111186015044952 Affinity Capture-Western; Reconstituted Complex
SKP2RB111239315469821 Affinity Capture-Western
SKP2RB111186015469821 Affinity Capture-Western
LIN9RB113042015479636 15538385 Affinity Capture-Western; Reconstituted Complex
LIN9RB111186015479636 15538385 Affinity Capture-Western; Reconstituted Complex
LIN54RB112632815479636 Reconstituted Complex
LIN54RB111186015479636 Reconstituted Complex
STAT3RB111265115677471 Affinity Capture-Western; Co-localization; Reconstituted Complex
STAT3RB111186015677471 Affinity Capture-Western; Co-localization; Reconstituted Complex
KDM4ARB111503515927959 Affinity Capture-Western; Two-hybrid
KDM4ARB111186015927959 Affinity Capture-Western; Two-hybrid
KDM5BRB111598416645588 Affinity Capture-Western
KDM5BRB111186016645588 Affinity Capture-Western
HMGA2RB111376316766265 Affinity Capture-Western; Far Western; Reconstituted Complex
HMGA2RB111186016766265 Affinity Capture-Western; Far Western; Reconstituted Complex
L3MBTL1RB111186017540172 Affinity Capture-Western
L3MBTL1RB111748617540172 Affinity Capture-Western
L3MBTL2RB112375317540172 Affinity Capture-Western
L3MBTL2RB111186017540172 Affinity Capture-Western
KDM1ARB111186018216119 Affinity Capture-Western
KDM1ARB111666718216119 Affinity Capture-Western
ZBTB7ARB111948818801742 Affinity Capture-Western
ZBTB7ARB111186018801742 Affinity Capture-Western
AURKBRB111464619225156 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
AURKBRB111186019225156 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
RB1MCM71833119566894 MCM7 interacts with Rb.
RB1MDM219721515577944 Rb interacts with Mdm2.
RB1MITF21494915716956 An unspecified isoform of Mitf interacts with Rb.
RB1MAPK118223615489336 RB1 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97874
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040428-1'