AutismKB 2.0

Annotation Details for PLEKHA1


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Basic Information Top
Gene Symbol:PLEKHA1 ( TAPP1 )
Gene Full Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Band: 10q26.13
Quick LinksEntrez ID:59338; OMIM: 607772; Uniprot ID:PKHA1_HUMAN; ENSEMBL ID: ENSG00000107679; HGNC ID: 14335
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm12101241
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane12101241
GO:0005886TAS-plasma membrane-
GO:0032587IDA-ruffle membrane12101241
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11802782
GO:0030165IPI-PDZ domain binding11802782
GO:0043325IDA-phosphatidylinositol-3,4-bisphosphate binding11001876
GO ID Evidence Qualifier GO_term References
GO:0001553IEA-luteinization-
GO:0006661TAS-phosphatidylinositol biosynthetic process-
GO:0007283IEA-spermatogenesis-
GO:0008209IEA-androgen metabolic process-
GO:0008210IEA-estrogen metabolic process-
GO:0009791IEA-post-embryonic development-
GO:0014065IDA-phosphatidylinositol 3-kinase signaling12101241
GO:0031529IDA-ruffle organization15485858
GO:0033327IEA-Leydig cell differentiation-
GO:0035264IEA-multicellular organism growth-
GO:0045184IDA-establishment of protein localization14516276
GO:0048008IEA-platelet-derived growth factor receptor signaling pathway-
GO:0048705IEA-skeletal system morphogenesis-
GO:0050853IDA-B cell receptor signaling pathway12101241
GO:0051898IMP-negative regulation of protein kinase B signaling14516276
GO:0060021IEA-palate development-
GO:0060325IEA-face morphogenesis-
GO:0070301IDA-cellular response to hydrogen peroxide14516276
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PLEKHA1MPDZ11430711802782 Affinity Capture-Western; Two-hybrid
PLEKHA1MPDZ12188011802782 Affinity Capture-Western; Two-hybrid
PLEKHA2PLEKHA112188011802782 Two-hybrid
PLEKHA2PLEKHA112188111802782 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2442213
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2780'