AutismKB 2.0

Annotation Details for TRPV4


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Basic Information Top
Gene Symbol:TRPV4 ( CMT2C,HMSN2C,OTRPC4,SPSMA,TRP12,VRL2,VROAC )
Gene Full Name: transient receptor potential cation channel, subfamily V, member 4
Band: 12q24.11
Quick LinksEntrez ID:59341; OMIM: 605427; Uniprot ID:TRPV4_HUMAN; ENSEMBL ID: ENSG00000111199; HGNC ID: 18083
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005881ISScolocalizes_withcytoplasmic microtubule-
GO:0005886IDA-plasma membrane15753126
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0005912ISS-adherens junction-
GO:0005925ISS-focal adhesion-
GO:0005929IBA-cilium-
GO:0009986IEA-cell surface-
GO:0016021NAS-integral component of membrane11025659
GO:0016324IEA-apical plasma membrane-
GO:0030027ISS-lamellipodium-
GO:0030175ISS-filopodium-
GO:0030426ISS-growth cone-
GO:0030864ISS-cortical actin cytoskeleton-
GO:0031410IEA-cytoplasmic vesicle-
GO:0032587ISS-ruffle membrane-
GO ID Evidence Qualifier GO_term References
GO:0003779ISS-actin binding-
GO:0005034IEA-osmosensor activity-
GO:0005080ISS-protein kinase C binding-
GO:0005261IDA-cation channel activity12724311
GO:0005262IDA-calcium channel activity18458941
GO:0005262TAS-calcium channel activity-
GO:0005515IPI-protein binding16293632
GO:0005516IMP-calmodulin binding12724311
GO:0005524IEA-ATP binding-
GO:0008017ISS-microtubule binding-
GO:0015275IMP-stretch-activated, cation-selective, calcium channel activity23136043
GO:0019901IPI-protein kinase binding12538589
GO:0042169ISS-SH2 domain binding-
GO:0043014ISS-alpha-tubulin binding-
GO:0048487ISS-beta-tubulin binding-
GO:0051015ISS-actin filament binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0002024IEA-diet induced thermogenesis-
GO:0006816IDA-calcium ion transport18458941
GO:0006816NAS-calcium ion transport11025659
GO:0006874IDA-cellular calcium ion homeostasis12724311
GO:0006884TAS-cell volume homeostasis12724311
GO:0007015IBA-actin filament organization-
GO:0007015ISS-actin filament organization-
GO:0007043ISS-cell-cell junction assembly-
GO:0007204IDA-positive regulation of cytosolic calcium ion concentration18458941
GO:0007231ISS-osmosensory signaling pathway-
GO:0007231TAS-osmosensory signaling pathway12724311
GO:0009612TAS-response to mechanical stimulus15753126
GO:0010628IEA-positive regulation of gene expression-
GO:0010759IEA-positive regulation of macrophage chemotaxis-
GO:0010977ISS-negative regulation of neuron projection development-
GO:0030103IEA-vasopressin secretion-
GO:0031117ISS-positive regulation of microtubule depolymerization-
GO:0031532ISS-actin cytoskeleton reorganization-
GO:0032868IEA-response to insulin-
GO:0034605ISS-cellular response to heat-
GO:0042538IEA-hyperosmotic salinity response-
GO:0042593IEA-glucose homeostasis-
GO:0043117IMP-positive regulation of vascular permeability23136043
GO:0043622ISS-cortical microtubule organization-
GO:0046330IEA-positive regulation of JNK cascade-
GO:0046785ISS-microtubule polymerization-
GO:0047484IEA-regulation of response to osmotic stress-
GO:0050729IEA-positive regulation of inflammatory response-
GO:0050891IMP-multicellular organismal water homeostasis23136043
GO:0060351IMP-cartilage development involved in endochondral bone morphogenesis26249260
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0070509ISS-calcium ion import-
GO:0070588IMP-calcium ion transmembrane transport23136043
GO:0070588TAS-calcium ion transmembrane transport-
GO:0071470ISS-cellular response to osmotic stress-
GO:0071476IMP-cellular hypotonic response23136043
GO:0071476ISS-cellular hypotonic response-
GO:0071477IEA-cellular hypotonic salinity response-
GO:0071639IEA-positive regulation of monocyte chemotactic protein-1 production-
GO:0071642IEA-positive regulation of macrophage inflammatory protein 1 alpha production-
GO:0071651IEA-positive regulation of chemokine (C-C motif) ligand 5 production-
GO:0097497IMP-blood vessel endothelial cell delamination23136043
GO:1903444IEA-negative regulation of brown fat cell differentiation-
GO:1903759IEA-signal transduction involved in regulation of aerobic respiration-
GO:2000340IEA-positive regulation of chemokine (C-X-C motif) ligand 1 production-
GO:2000507IEA-positive regulation of energy homeostasis-
GO:2000778IEA-positive regulation of interleukin-6 secretion-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRPV4FYN12188312538589 Affinity Capture-Western
TRPV4FYN10881012538589 Affinity Capture-Western
TRPV4HCK12188312538589 Affinity Capture-Western
TRPV4HCK10930512538589 Affinity Capture-Western
TRPV4LCK12188312538589 Affinity Capture-Western
TRPV4LCK11012412538589 Affinity Capture-Western
TRPV4LYN11024512538589 Affinity Capture-Western; Biochemical Activity
TRPV4LYN12188312538589 Affinity Capture-Western; Biochemical Activity
TRPV4SRC11259212538589 Affinity Capture-Western
TRPV4SRC12188312538589 Affinity Capture-Western
TRPV4UBC11316417932042 Affinity Capture-Western
TRPV4UBC12188317932042 Affinity Capture-Western
TRPV4YES112188312538589 Affinity Capture-Western
TRPV4YES111335712538589 Affinity Capture-Western
TRPV4MAP712188314517216 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRPV4MAP711451514517216 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRPV4OS912188317932042 Affinity Capture-Western
TRPV4OS911615617932042 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1926945
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030912-7'