AutismKB 2.0

Annotation Details for BCL2


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Basic Information Top
Gene Symbol:BCL2 ( Bcl-2 )
Gene Full Name: B-cell CLL/lymphoma 2
Band: 18q21.33
Quick LinksEntrez ID:596; OMIM: 151430; Uniprot ID:BCL2_HUMAN; ENSEMBL ID: ENSG00000171791; HGNC ID: 990
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus7546744
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm7546744
GO:0005739IDA-mitochondrion7896880
GO:0005741IDA-mitochondrial outer membrane8402648
GO:0005741TAS-mitochondrial outer membrane-
GO:0005783IDA-endoplasmic reticulum8402648
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005829IEA-cytosol-
GO:0016020IDA-membrane7896880
GO:0031965IDA-nuclear membrane1502141
GO:0043209IEA-myelin sheath-
GO:0043234IMP-protein complex15733859
GO:0046930IDA-pore complex9219694
GO ID Evidence Qualifier GO_term References
GO:0002020IDA-protease binding10620603
GO:0005515IPI-protein binding7954800
GO:0008134IEA-transcription factor binding-
GO:0015267IDA-channel activity9219694
GO:0016248IDA-channel inhibitor activity9219694
GO:0031625IPI-ubiquitin protein ligase binding20889974
GO:0042802IPI-identical protein binding9463381
GO:0042803IPI-protein homodimerization activity9111042
GO:0043565IDA-sequence-specific DNA binding12086670
GO:0046982IPI-protein heterodimerization activity9111042
GO:0051434IPI-BH3 domain binding9111042
GO:0051721IEA-protein phosphatase 2A binding-
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination16717086
GO:0001503IEA-ossification-
GO:0001541IEA-ovarian follicle development-
GO:0001656IEA-metanephros development-
GO:0001658IEA-branching involved in ureteric bud morphogenesis-
GO:0001662IEA-behavioral fear response-
GO:0001782IEA-B cell homeostasis-
GO:0001836ISS-release of cytochrome c from mitochondria9843949
GO:0001836NAS-release of cytochrome c from mitochondria9027314
GO:0001952IEA-regulation of cell-matrix adhesion-
GO:0002320IEA-lymphoid progenitor cell differentiation-
GO:0002326IEA-B cell lineage commitment-
GO:0002931IEA-response to ischemia-
GO:0003014IEA-renal system process-
GO:0006470IEA-protein dephosphorylation-
GO:0006582IEA-melanin metabolic process-
GO:0006808IEA-regulation of nitrogen utilization-
GO:0006915IDA-apoptotic process36599
GO:0006959TAS-humoral immune response1908951
GO:0006974IMP-cellular response to DNA damage stimulus17875758
GO:0007015IEA-actin filament organization-
GO:0007409IEA-axonogenesis-
GO:0007565NAS-female pregnancy11530860
GO:0007569IEA-cell aging-
GO:0008584IEA-male gonad development-
GO:0008625IDA-extrinsic apoptotic signaling pathway via death domain receptors10597216
GO:0008631IEA-intrinsic apoptotic signaling pathway in response to oxidative stress-
GO:0009314NAS-response to radiation15799693
GO:0009636IDA-response to toxic substance16307838
GO:0009791IEA-post-embryonic development-
GO:0010039IDA-response to iron ion11264898
GO:0010224IEA-response to UV-B-
GO:0010332IEA-response to gamma radiation-
GO:0010468IEA-regulation of gene expression-
GO:0010507TAS-negative regulation of autophagy18309324
GO:0010523IEA-negative regulation of calcium ion transport into cytosol-
GO:0010559IEA-regulation of glycoprotein biosynthetic process-
GO:0014031IEA-mesenchymal cell development-
GO:0014042IEA-positive regulation of neuron maturation-
GO:0014911IEA-positive regulation of smooth muscle cell migration-
GO:0016049IEA-cell growth-
GO:0016337IEA-single organismal cell-cell adhesion-
GO:0018105IEA-peptidyl-serine phosphorylation-
GO:0018107IEA-peptidyl-threonine phosphorylation-
GO:0021747IEA-cochlear nucleus development-
GO:0022612IEA-gland morphogenesis-
GO:0022898IDA-regulation of transmembrane transporter activity9219694
GO:0030279IEA-negative regulation of ossification-
GO:0030307IDA-positive regulation of cell growth8022822
GO:0030308IEA-negative regulation of cell growth-
GO:0030318IEA-melanocyte differentiation-
GO:0030336IEA-negative regulation of cell migration-
GO:0030890IMP-positive regulation of B cell proliferation17875758
GO:0031069IEA-hair follicle morphogenesis-
GO:0031103IEA-axon regeneration-
GO:0031647IEA-regulation of protein stability-
GO:0032469TAS-endoplasmic reticulum calcium ion homeostasis18309324
GO:0032835IEA-glomerulus development-
GO:0032848IDA-negative regulation of cellular pH reduction10506221
GO:0033033IEA-negative regulation of myeloid cell apoptotic process-
GO:0033077IEA-T cell differentiation in thymus-
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0033689IEA-negative regulation of osteoblast proliferation-
GO:0034097IDA-response to cytokine9184696
GO:0035094IDA-response to nicotine12421819
GO:0035265IEA-organ growth-
GO:0040018IEA-positive regulation of multicellular organism growth-
GO:0042100IDA-B cell proliferation1373874
GO:0042149IEA-cellular response to glucose starvation-
GO:0042493IDA-response to drug36599
GO:0042493IMP-response to drug17875758
GO:0042542IEA-response to hydrogen peroxide-
GO:0043029IEA-T cell homeostasis-
GO:0043066IDA-negative regulation of apoptotic process1373874
GO:0043066IGI-negative regulation of apoptotic process9660918
GO:0043066IMP-negative regulation of apoptotic process7772249
GO:0043085IEA-positive regulation of catalytic activity-
GO:0043375IEA-CD8-positive, alpha-beta T cell lineage commitment-
GO:0043496IDA-regulation of protein homodimerization activity9111042
GO:0043497IDA-regulation of protein heterodimerization activity9111042
GO:0043524IDA-negative regulation of neuron apoptotic process7546744
GO:0043583IEA-ear development-
GO:0045069IEA-regulation of viral genome replication-
GO:0045636IEA-positive regulation of melanocyte differentiation-
GO:0046671IEA-negative regulation of retinal cell programmed cell death-
GO:0046902ISS-regulation of mitochondrial membrane permeability9843949
GO:0048041IEA-focal adhesion assembly-
GO:0048536IEA-spleen development-
GO:0048538IEA-thymus development-
GO:0048546IEA-digestive tract morphogenesis-
GO:0048599IEA-oocyte development-
GO:0048743IEA-positive regulation of skeletal muscle fiber development-
GO:0048753IEA-pigment granule organization-
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0050853IMP-B cell receptor signaling pathway17875758
GO:0051384IEA-response to glucocorticoid-
GO:0051402TAS-neuron apoptotic process16167175
GO:0051607IDA-defense response to virus10620603
GO:0051881ISS-regulation of mitochondrial membrane potential9843949
GO:0051902TAS-negative regulation of mitochondrial depolarization9027314
GO:0051924IDA-regulation of calcium ion transport8022822
GO:0055085IEA-transmembrane transport-
GO:0070059IDA-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress15776018
GO:0071310IEA-cellular response to organic substance-
GO:0071456IEA-cellular response to hypoxia-
GO:0072593IEA-reactive oxygen species metabolic process-
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
GO:1900740TAS-positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
GO:2000134IEA-negative regulation of G1/S transition of mitotic cell cycle-
GO:2000378IEA-negative regulation of reactive oxygen species metabolic process-
GO:2000811IMP-negative regulation of anoikis15006356
GO:2001234IMP-negative regulation of apoptotic signaling pathway20097879
GO:2001240IGI-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand8358790
GO:2001243IDA-negative regulation of intrinsic apoptotic signaling pathway11684014
GO:2001244TAS-positive regulation of intrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BCL2PARP110665211790116 Reconstituted Complex
BCL2PARP110706811790116 Reconstituted Complex
BCL2BAD1070487834748 15694340 Affinity Capture-Western; Two-hybrid
BCL2BAD1070687834748 15694340 Affinity Capture-Western; Two-hybrid
BCL2BAG11070499305631 Reconstituted Complex
BCL2BAG11070689305631 Reconstituted Complex
BCL2BAK110706811728179 14980220 Affinity Capture-Western; Protein-peptide
BCL2BAK110705411728179 14980220 Affinity Capture-Western; Protein-peptide
BCL2BAX1070688358790 10620799 14980220 15231068 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL2BAX1070578358790 10620799 14980220 15231068 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BNIP3BCL21071327954800 10625696 Affinity Capture-Western; Two-hybrid
BNIP3BCL21070687954800 10625696 Affinity Capture-Western; Two-hybrid
BNIP2BCL21071317954800 12901880 Reconstituted Complex; Two-hybrid
BNIP2BCL21070687954800 12901880 Reconstituted Complex; Two-hybrid
RRASBCL21121518232588 Affinity Capture-Western; Two-hybrid
RRASBCL21070688232588 Affinity Capture-Western; Two-hybrid
TP53BP2BCL21130128668206 Reconstituted Complex; Two-hybrid
TP53BP2BCL21070688668206 Reconstituted Complex; Two-hybrid
RAF1BCL21070688929532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1BCL21118318929532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPP3CABCL21115229109491 Affinity Capture-Western
PPP3CABCL21070689109491 Affinity Capture-Western
TOMM20BCL21070689119086 Reconstituted Complex
TOMM20BCL21151449119086 Reconstituted Complex
HRKBCL21142769130713 15694340 Affinity Capture-Western; Protein-peptide; Two-hybrid
HRKBCL21070689130713 15694340 Affinity Capture-Western; Protein-peptide; Two-hybrid
BCAP31BCL21154379334338 Affinity Capture-Western; Reconstituted Complex
BCAP31BCL21070689334338 Affinity Capture-Western; Reconstituted Complex
SMN1BCL21124909389483 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMN1BCL21070689389483 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL2L11BCL21070689430630 9731710 15694340 19805519 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL2L11BCL21153359430630 9731710 15694340 19805519 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BLKBCL21071099525867 Reconstituted Complex
BLKBCL21070689525867 Reconstituted Complex
TMBIM6BCL21070689660918 Affinity Capture-Western
TMBIM6BCL21128689660918 Affinity Capture-Western
BECN1BCL21142269765397 FRET; Two-hybrid
BECN1BCL21070689765397 FRET; Two-hybrid
PPP2CABCL21070689852076 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PPP2CABCL21115079852076 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BNIPLBCL21272119973195 12901880 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BNIPLBCL21070689973195 12901880 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DYNLL1BCL211420610198631 Affinity Capture-Western
DYNLL1BCL210706810198631 Affinity Capture-Western
BNIP1BCL210713010217402 Reconstituted Complex
BNIP1BCL210706810217402 Reconstituted Complex
HSPA1ABCL210953510354271 Affinity Capture-Western
HSPA1ABCL210706810354271 Affinity Capture-Western
BNIP3LBCL210713310467396 Affinity Capture-Western
BNIP3LBCL210706810467396 Affinity Capture-Western
PSEN1BCL210706810521466 Affinity Capture-Western; Two-hybrid
PSEN1BCL211164210521466 Affinity Capture-Western; Two-hybrid
RAD9ABCL211182010620799 18794804 Affinity Capture-Western; Two-hybrid
RAD9ABCL210706810620799 18794804 Affinity Capture-Western; Two-hybrid
IRS1BCL210987410679027 Affinity Capture-Western
IRS1BCL210706810679027 Affinity Capture-Western
IRS2BCL211420910679027 Affinity Capture-Western
IRS2BCL210706810679027 Affinity Capture-Western
PMAIP1BCL211137910807576 15694340 Affinity Capture-Western; Protein-peptide
PMAIP1BCL210706810807576 15694340 Affinity Capture-Western; Protein-peptide
AVENBCL210706810949025 Affinity Capture-Western; Two-hybrid
AVENBCL212136610949025 Affinity Capture-Western; Two-hybrid
MOAP1BCL212206911060313 Affinity Capture-Western
MOAP1BCL210706811060313 Affinity Capture-Western
RTN4BCL212140011126360 Affinity Capture-Western; Two-hybrid
RTN4BCL210706811126360 Affinity Capture-Western; Two-hybrid
BCL2L10BCL211533411278245 Affinity Capture-Western
BCL2L10BCL210706811278245 Affinity Capture-Western
PIN1BCL210706811326318 Affinity Capture-Western
PIN1BCL211131711326318 Affinity Capture-Western
CDK1BCL210706811326318 11774038 Affinity Capture-Western
CDK1BCL210742011326318 11774038 Affinity Capture-Western
CASP8BCL210706811406564 11832478 Affinity Capture-Western; Phenotypic Suppression
CASP8BCL210729111406564 11832478 Affinity Capture-Western; Phenotypic Suppression
BBC3BCL211800911463392 15694340 Affinity Capture-Western
BBC3BCL210706811463392 15694340 Affinity Capture-Western
BMFBCL212471611546872 Affinity Capture-Western
BMFBCL210706811546872 Affinity Capture-Western
CASP3BCL210728611752215 Biochemical Activity
CASP3BCL210706811752215 Biochemical Activity
CASP2BCL210728511832478 Phenotypic Suppression
CASP2BCL210706811832478 Phenotypic Suppression
PPP2R5ABCL210706811929874 Affinity Capture-Western
PPP2R5ABCL211151711929874 Affinity Capture-Western
CAPN2BCL210706812000759 Biochemical Activity; Reconstituted Complex
CAPN2BCL210727412000759 Biochemical Activity; Reconstituted Complex
TP53AIP1BCL212201812019168 Affinity Capture-Western
TP53AIP1BCL210706812019168 Affinity Capture-Western
ITM2BBCL211483512082633 Affinity Capture-Western
ITM2BBCL210706812082633 Affinity Capture-Western
BCL2L1BCL210706812137781 14980220 Affinity Capture-Western; Protein-peptide
BCL2L1BCL210707012137781 14980220 Affinity Capture-Western; Protein-peptide
FKBP8BCL211727012510191 Affinity Capture-Western
FKBP8BCL210706812510191 Affinity Capture-Western
SPNS1BCL212383612815463 Affinity Capture-Western
SPNS1BCL210706812815463 Affinity Capture-Western
BIKBCL210706812853473 15694340 Affinity Capture-Western; Protein-peptide
BIKBCL210710712853473 15694340 Affinity Capture-Western; Protein-peptide
NR4A1BCL210940714980220 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR4A1BCL210706814980220 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MYCBCL211069415210690 Affinity Capture-Western; Co-localization
MYCBCL210706815210690 Affinity Capture-Western; Co-localization
EPHB2BCL210836215225643 Biochemical Activity
EPHB2BCL210706815225643 Biochemical Activity
PPP2R4BCL211151615225643 Biochemical Activity
PPP2R4BCL210706815225643 Biochemical Activity
SERPINB8BCL210706815231068 Affinity Capture-Western
SERPINB8BCL211128915231068 Affinity Capture-Western
SOD1BCL211253015233914 Affinity Capture-Western; Reconstituted Complex
SOD1BCL210706815233914 Affinity Capture-Western; Reconstituted Complex
BIDBCL210706815520201 15694340 Protein-peptide
BIDBCL210710615520201 15694340 Protein-peptide
ITPR1BCL210991315613488 Affinity Capture-Western
ITPR1BCL210706815613488 Affinity Capture-Western
UBCBCL211316416980304 Affinity Capture-Western
UBCBCL210706816980304 Affinity Capture-Western
BLIDBCL213609720400521 Affinity Capture-Western
BLIDBCL210706820400521 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
BBC3BCL219645911463392 PUMA-beta interacts with Bcl-2.
BIDBCL219317715574335 Bid interacts with Bcl-2.
BAG3BCL225942111527400 Bcl-2 interacts with BAG-3. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-3.
BAG4BCL225942211527400 Bcl-2 interacts with BAG-4. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-4.
BBC3BCL219645811463392 PUMA-alpha interacts with Bcl-2.
BBC3BCL219318215574335 PUMA interacts with Bcl-2.
RTN4BCL219737911126360 RTN-XS interacts with Bcl-2.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
BCL2rs1564483, rs1801018 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
BCL2rs1564483, rs2051424, rs3810031 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:88138
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-051012-1'