AutismKB 2.0

Annotation Details for RDX


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Basic Information Top
Gene Symbol:RDX ( DFNB24 )
Gene Full Name: radixin
Band: 11q23
Quick LinksEntrez ID:5962; OMIM: 179410; Uniprot ID:RADI_HUMAN; ENSEMBL ID: ENSG00000137710; HGNC ID: 9944
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IEA-ruffle-
GO:0005615IDA-extracellular space16502470
GO:0005886IDA-plasma membrane-
GO:0005886ISScolocalizes_withplasma membrane-
GO:0005902ISS-microvillus-
GO:0005913IEA-cell-cell adherens junction-
GO:0005925IDA-focal adhesion21423176
GO:0005925IDAcolocalizes_withfocal adhesion21282464
GO:0016324IDA-apical plasma membrane17825285
GO:0030027ISS-lamellipodium-
GO:0030175ISS-filopodium-
GO:0030315IEA-T-tubule-
GO:0030496IEA-midbody-
GO:0030864ISS-cortical actin cytoskeleton-
GO:0032154IEA-cleavage furrow-
GO:0032420IEA-stereocilium-
GO:0043209IEA-myelin sheath-
GO:0051286IEA-cell tip-
GO:0070062IDA-extracellular exosome19056867
GO:0071944IDA-cell periphery22291017
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0003779IDA-actin binding17825285
GO:0005515IPI-protein binding10806479
GO:0019904IEA-protein domain specific binding-
GO:0042803ISS-protein homodimerization activity16582480
GO:0045296IDA-cadherin binding25468996
GO:0051018ISS-protein kinase A binding-
GO:0051117IPI-ATPase binding17825285
GO ID Evidence Qualifier GO_term References
GO:0008360IMP-regulation of cell shape22467863
GO:0008361IGI-regulation of cell size22467863
GO:0010628IGI-positive regulation of gene expression23264465
GO:0010737ISS-protein kinase A signaling-
GO:0030033IEA-microvillus assembly-
GO:0030335IMP-positive regulation of cell migration22467863
GO:0032231IMP-regulation of actin filament bundle assembly22467863
GO:0032487ISS-regulation of Rap protein signal transduction-
GO:0034111IMP-negative regulation of homotypic cell-cell adhesion22467863
GO:0034260IMP-negative regulation of GTPase activity22467863
GO:0036120IEA-cellular response to platelet-derived growth factor stimulus-
GO:0043087IGI-regulation of GTPase activity22467863
GO:0045176IEA-apical protein localization-
GO:0045184ISS-establishment of protein localization-
GO:0045792IMP-negative regulation of cell size22467863
GO:0051016IEA-barbed-end actin filament capping-
GO:0061028IGI-establishment of endothelial barrier23264465
GO:0090002IMP-establishment of protein localization to plasma membrane17825285
GO:0097067ISS-cellular response to thyroid hormone stimulus-
GO:1900027IMP-regulation of ruffle assembly22467863
GO:1900087ISS-positive regulation of G1/S transition of mitotic cell cycle-
GO:1902115IGI-regulation of organelle assembly21148287
GO:1902966IGI-positive regulation of protein localization to early endosome21148287
GO:1903364IGI-positive regulation of cellular protein catabolic process21148287
GO:1903392IMP-negative regulation of adherens junction organization22467863
GO:2000643IGI-positive regulation of early endosome to late endosome transport21148287
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RDXARHGDIA1068899287351 Reconstituted Complex
RDXARHGDIA1118949287351 Reconstituted Complex
RDXDRD311189414499480 Two-hybrid
RDXDRD310814814499480 Two-hybrid
RDXICAM210961111375520 Co-crystal Structure
RDXICAM211189411375520 Co-crystal Structure
GNA13RDX11591410816569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNA13RDX11189410816569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PHLPP2RDX11189419615732 Affinity Capture-MS
PHLPP2RDX11667419615732 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
TSC1RDX2485310806479 Hamartin interacts with radixin. This interaction was modeled on a demonstrated interaction between murine hamartin and human radixin.
SLC9A3R1RDX548569430655 Radixin interacts with hNHE-RF. This interaction was modeled on a demonstrated interaction between chicken radixin and human hNHE-RF.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97887
  • Data Attributes: MGI curated and HomoloGene calculated
No data