AutismKB 2.0

Annotation Details for UPF1


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Basic Information Top
Gene Symbol:UPF1 ( FLJ43809,FLJ46894,HUPF1,KIAA0221,NORF1,RENT1,pNORF1 )
Gene Full Name: UPF1 regulator of nonsense transcripts homolog (yeast)
Band: 19p13.11
Quick LinksEntrez ID:5976; OMIM: 601430; Uniprot ID:RENT1_HUMAN; ENSEMBL ID: ENSG00000005007; HGNC ID: 9962
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IDA-nuclear chromosome, telomeric region21829167
GO:0000785IDA-chromatin16488880
GO:0000932IEA-P-body-
GO:0005634IDA-nucleus18362360
GO:0005654IDA-nucleoplasm-
GO:0005737NAS-cytoplasm9064659
GO:0005829TAS-cytosol-
GO:0035145IDA-exon-exon junction complex16601204
GO:0044530IDA-supraspliceosomal complex18362360
GO ID Evidence Qualifier GO_term References
GO:0003682IDA-chromatin binding16488880
GO:0003723IDA-RNA binding22658674
GO:0003723NAS-RNA binding10999600
GO:0004004IDA-ATP-dependent RNA helicase activity12554878
GO:0004004TAS-ATP-dependent RNA helicase activity-
GO:0004386NAS-helicase activity9064659
GO:0005515IPI-protein binding9620853
GO:0005524IEA-ATP binding-
GO:0008270IEA-zinc ion binding-
GO:0042162IDA-telomeric DNA binding17916692
GO ID Evidence Qualifier GO_term References
GO:0000184IDA-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay17468741
GO:0000184IMP-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay18369367
GO:0000184NAS-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay10999600
GO:0000184TAS-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay8855285
GO:0000294IMP-nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay26255671
GO:0000956IMP-nuclear-transcribed mRNA catabolic process23828042
GO:0006260IMP-DNA replication16488880
GO:0006281IDA-DNA repair16488880
GO:0006406TAS-mRNA export from nucleus16488880
GO:0006449IMP-regulation of translational termination9620853
GO:0006449NAS-regulation of translational termination10999600
GO:0009048IEA-dosage compensation by inactivation of X chromosome-
GO:0032201IDA-telomere maintenance via semi-conservative replication21829167
GO:0032204IMP-regulation of telomere maintenance17916692
GO:0044770IMP-cell cycle phase transition16488880
GO:0061014IMP-positive regulation of mRNA catabolic process25225333
GO:0061158IMP-3'-UTR-mediated mRNA destabilization26255671
GO:0071044IMP-histone mRNA catabolic process16086026
GO:0071222IDA-cellular response to lipopolysaccharide26255671
GO:0071347IDA-cellular response to interleukin-126255671
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UPF1ATR10702716488880 Biochemical Activity
UPF1ATR11190816488880 Biochemical Activity
UPF1PARN11110714527413 Affinity Capture-Western
UPF1PARN11190814527413 Affinity Capture-Western
UPF1EXOSC1011190814527413 Affinity Capture-Western
UPF1EXOSC1011140314527413 Affinity Capture-Western
UPF1POLD111142016488880 Affinity Capture-Western
UPF1POLD111190816488880 Affinity Capture-Western
UPF2UPF111190811073994 11163187 11544179 12723973 14527413 16086026 16488880 Affinity Capture-MS; Affinity Capture-Western
UPF2UPF111749011073994 11163187 11544179 12723973 14527413 16086026 16488880 Affinity Capture-MS; Affinity Capture-Western
UPF3BUPF111190811163187 12723973 14527413 Affinity Capture-Western
UPF3BUPF112239611163187 12723973 14527413 Affinity Capture-Western
UPF3AUPF111190811163187 11544179 12723973 Affinity Capture-Western
UPF3AUPF112239711163187 11544179 12723973 Affinity Capture-Western
SMG1UPF111668711544179 Affinity Capture-Western; Biochemical Activity; Protein-peptide
SMG1UPF111190811544179 Affinity Capture-Western; Biochemical Activity; Protein-peptide
DCP2UPF111190812417715 14527413 Affinity Capture-Western
DCP2UPF112794412417715 14527413 Affinity Capture-Western
DCP1AUPF111190812417715 Affinity Capture-Western
DCP1AUPF112091412417715 Affinity Capture-Western
PABPC1UPF111793912723973 Affinity Capture-MS
PABPC1UPF111190812723973 Affinity Capture-MS
EXOSC2UPF111190814527413 Affinity Capture-Western
EXOSC2UPF111697714527413 Affinity Capture-Western
XRN1UPF111997014527413 Affinity Capture-Western
XRN1UPF111190814527413 Affinity Capture-Western
EXOSC4UPF112000714527413 Affinity Capture-Western
EXOSC4UPF111190814527413 Affinity Capture-Western
NAA38UPF111967915231747 Two-hybrid
NAA38UPF111190815231747 Two-hybrid
HIRAUPF111190815231747 Two-hybrid
HIRAUPF111314115231747 Two-hybrid
SLBPUPF111362716086026 Affinity Capture-Western
SLBPUPF111190816086026 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107995
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2836'