AutismKB 2.0

Annotation Details for REST


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Basic Information Top
Gene Symbol:REST ( NRSF,XBR )
Gene Full Name: RE1-silencing transcription factor
Band: 4q12
Quick LinksEntrez ID:5978; OMIM: 600571; Uniprot ID:REST_HUMAN; ENSEMBL ID: ENSG00000084093; HGNC ID: 9966
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus7697725
GO:0005634NAS-nucleus7871435
GO:0005654TAS-nucleoplasm-
GO:0005829IEA-cytosol-
GO:0017053IDA-transcriptional repressor complex10734093
GO ID Evidence Qualifier GO_term References
GO:0001046IDA-core promoter sequence-specific DNA binding8568247
GO:0001047IDA-core promoter binding17984088
GO:0001078IDA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding10449787
GO:0001228IEA-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0003682ISS-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding19342457
GO:0004407TAS-histone deacetylase activity-
GO:0005515IPI-protein binding10449787
GO:0008134IPI-transcription factor binding17130167
GO:0015271IMP-outward rectifier potassium channel activity18570921
GO:0044212IDA-transcription regulatory region DNA binding17555596
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter8568247
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter7697725
GO:0002244IEA-hematopoietic progenitor cell differentiation-
GO:0006355NAS-regulation of transcription, DNA-templated7871435
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0008285IMP-negative regulation of cell proliferation20564196
GO:0010629IMP-negative regulation of gene expression20564196
GO:0032348IMP-negative regulation of aldosterone biosynthetic process19342457
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0035690IMP-cellular response to drug20564196
GO:0043065IMP-positive regulation of apoptotic process20564196
GO:0043280IMP-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process20564196
GO:0043922IDA-negative regulation by host of viral transcription17555596
GO:0045665IMP-negative regulation of neuron differentiation18570921
GO:0045892IDA-negative regulation of transcription, DNA-templated7697725
GO:0045892IMP-negative regulation of transcription, DNA-templated18570921
GO:0045892NAS-negative regulation of transcription, DNA-templated7871435
GO:0045893IDA-positive regulation of transcription, DNA-templated17984088
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0045955ISS-negative regulation of calcium ion-dependent exocytosis-
GO:0046676IMP-negative regulation of insulin secretion20942606
GO:0050768ISS-negative regulation of neurogenesis-
GO:0060379ISS-cardiac muscle cell myoblast differentiation-
GO:0070933IDA-histone H4 deacetylation17555596
GO:0071257IMP-cellular response to electrical stimulus18570921
GO:0071385IDA-cellular response to glucocorticoid stimulus17984088
GO:0071805IEA-potassium ion transmembrane transport-
GO:2000065IMP-negative regulation of cortisol biosynthetic process19342457
GO:2000706ISS-negative regulation of dense core granule biogenesis-
GO:2000740IMP-negative regulation of mesenchymal stem cell differentiation18570921
GO:2000798IMP-negative regulation of amniotic stem cell differentiation20942606
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RESTGTF2B11191015197246 Reconstituted Complex
RESTGTF2B10921415197246 Reconstituted Complex
RESTHDAC110931510491605 18806873 Affinity Capture-Western; Reconstituted Complex
RESTHDAC111191010491605 18806873 Affinity Capture-Western; Reconstituted Complex
RESTHDAC210931617468742 Affinity Capture-MS
RESTHDAC211191017468742 Affinity Capture-MS
RCOR1REST11679610449787 15897453 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RCOR1REST11191010449787 15897453 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3AREST11191010491605 Affinity Capture-Western
SIN3AREST11743910491605 Affinity Capture-Western
SMARCA4REST11191012192000 17023429 Affinity Capture-Western
SMARCA4REST11248112192000 17023429 Affinity Capture-Western
SMARCC2REST11191012192000 Affinity Capture-Western
SMARCC2REST11248512192000 Affinity Capture-Western
SMARCE1REST11248912192000 Affinity Capture-Western
SMARCE1REST11191012192000 Affinity Capture-Western
SIN3BREST11690115197246 Affinity Capture-Western
SIN3BREST11191015197246 Affinity Capture-Western
TBPREST11191015197246 Affinity Capture-Western; Reconstituted Complex
TBPREST11277115197246 Affinity Capture-Western; Reconstituted Complex
SP1REST11191015528196 Affinity Capture-Western
SP1REST11255015528196 Affinity Capture-Western
HDAC5REST11533117011572 Affinity Capture-Western
HDAC5REST11191017011572 Affinity Capture-Western
HDAC4REST11191017011572 Affinity Capture-Western
HDAC4REST11510617011572 Affinity Capture-Western
RNF2REST11197217468742 Affinity Capture-MS
RNF2REST11191017468742 Affinity Capture-MS
KDM5CREST11387017468742 Affinity Capture-MS
KDM5CREST11191017468742 Affinity Capture-MS
NCOR1REST11191017468742 Affinity Capture-MS
NCOR1REST11497317468742 Affinity Capture-MS
CDYLREST11481819061646 Affinity Capture-MS; Reconstituted Complex
CDYLREST11191019061646 Affinity Capture-MS; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104897
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080415-1'