AutismKB 2.0

Annotation Details for RET


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Basic Information Top
Gene Symbol:RET ( CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51 )
Gene Full Name: ret proto-oncogene
Band: 10q11.21
Quick LinksEntrez ID:5979; OMIM: 164761; Uniprot ID:RET_HUMAN; ENSEMBL ID: ENSG00000165731; HGNC ID: 9967
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005769IEA-early endosome-
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane19823924
GO:0010008IDA-endosome membrane19823924
GO:0030424IEA-axon-
GO:0030425IEA-dendrite-
GO:0043025IEA-neuronal cell body-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0043235IDA-receptor complex23382219
GO:0045121IEA-membrane raft-
GO:0098797IDA-plasma membrane protein complex10545102
GO ID Evidence Qualifier GO_term References
GO:0004713TAS-protein tyrosine kinase activity7824936
GO:0004714TAS-transmembrane receptor protein tyrosine kinase activity-
GO:0004872TAS-receptor activity7824936
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005509IDA-calcium ion binding11445581
GO:0005515IPI-protein binding8628282
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001657IEA-ureteric bud development-
GO:0001755IEA-neural crest cell migration-
GO:0001838IEA-embryonic epithelial tube formation-
GO:0006468TAS-protein phosphorylation7824936
GO:0007156IEA-homophilic cell adhesion via plasma membrane adhesion molecules-
GO:0007158IMP-neuron cell-cell adhesion21357690
GO:0007165TAS-signal transduction7824936
GO:0007169IEA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007411TAS-axon guidance-
GO:0007497TAS-posterior midgut development8114939
GO:0010976IMP-positive regulation of neuron projection development17910947
GO:0014042IEA-positive regulation of neuron maturation-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030155IDA-regulation of cell adhesion21357690
GO:0030335IDA-positive regulation of cell migration20702524
GO:0033141IEA-positive regulation of peptidyl-serine phosphorylation of STAT protein-
GO:0033619IDA-membrane protein proteolysis21357690
GO:0033630IDA-positive regulation of cell adhesion mediated by integrin20702524
GO:0035799IEA-ureter maturation-
GO:0042493IEA-response to drug-
GO:0042551IEA-neuron maturation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045793IEA-positive regulation of cell size-
GO:0045893ISS-positive regulation of transcription, DNA-templated17047028
GO:0048265ISS-response to pain-
GO:0048484IEA-enteric nervous system development-
GO:0050770IEA-regulation of axonogenesis-
GO:0060041IEA-retina development in camera-type eye-
GO:0060384IEA-innervation-
GO:0061146ISS-Peyer's patch morphogenesis-
GO:0071300IMP-cellular response to retinoic acid17910947
GO:0072300ISS-positive regulation of metanephric glomerulus development17047028
GO:0097021ISS-lymphocyte migration into lymphoid organs-
GO:2001241TAS-positive regulation of extrinsic apoptotic signaling pathway in absence of ligand21357690
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RETCRK1119119393871 Reconstituted Complex
RETCRK1077889393871 Reconstituted Complex
RETDOK111191112087092 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RETDOK110813112087092 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RETGFRA11089429192898 10829012 Reconstituted Complex
RETGFRA11119119192898 10829012 Reconstituted Complex
RETGRB21091427665556 8183561 Reconstituted Complex
RETGRB21119117665556 8183561 Reconstituted Complex
RETGRB71091438631863 Far Western; Reconstituted Complex
RETGRB71119118631863 Far Western; Reconstituted Complex
RETGRB101119117665556 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RETGRB101091447665556 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RETNRTN1109589192898 Affinity Capture-Western
RETNRTN1119119192898 Affinity Capture-Western
RETPLCG11119118628282 Reconstituted Complex
RETPLCG11113518628282 Reconstituted Complex
RETPTPRF11191111121408 Reconstituted Complex
RETPTPRF11175611121408 Reconstituted Complex
SHC1RET1119118183561 9047384 Affinity Capture-Western; Reconstituted Complex
SHC1RET1123618183561 9047384 Affinity Capture-Western; Reconstituted Complex
SRCRET11259210070972 Affinity Capture-Western
SRCRET11191110070972 Affinity Capture-Western
FRS2RET11603111360177 Reconstituted Complex
FRS2RET11191111360177 Reconstituted Complex
DOK4RET12083711470823 Affinity Capture-Western
DOK4RET11191111470823 Affinity Capture-Western
DOK2RET11191111470823 Affinity Capture-Western
DOK2RET11450811470823 Affinity Capture-Western
DOK5RET11191111470823 15286081 Affinity Capture-Western; Reconstituted Complex
DOK5RET12092611470823 15286081 Affinity Capture-Western; Reconstituted Complex
STAT3RET11191111536047 12637586 15485908 Affinity Capture-Western
STAT3RET11265111536047 12637586 15485908 Affinity Capture-Western
PDLIM7RET11468212176011 Affinity Capture-Western
PDLIM7RET11191112176011 Affinity Capture-Western
DOK6RET12863615286081 Affinity Capture-Western
DOK6RET11191115286081 Affinity Capture-Western
MCRS1RET11191116186106 Affinity Capture-Western
MCRS1RET11571016186106 Affinity Capture-Western
IKBKGRET11408920098747 Reconstituted Complex
IKBKGRET11191120098747 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
RETrs1799939, rs1800858, rs1800863, rs2075912, rs2075914, rs2472737, rs2505515, rs2505535, rs2506011, rs3026720, rs3026737, rs741763 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
RETrs1800863, rs2075914, rs2472737, rs2472740, rs2505515, rs2505535, rs2742240, rs3026737, rs3026762, rs741763 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97902
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-307'