AutismKB 2.0

Annotation Details for RIT2


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Basic Information Top
Gene Symbol:RIT2 ( RIBA,RIN,ROC2 )
Gene Full Name: Ras-like without CAAX 2
Band: 18q12.3
Quick LinksEntrez ID:6014; OMIM: 609592; Uniprot ID:RIT2_HUMAN; ENSEMBL ID: ENSG00000152214; HGNC ID: 10017
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16122393
GO:0005634ISS-nucleus-
GO:0005737ISS-cytoplasm-
GO:0005886IDA-plasma membrane16122393
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane8824319
GO:0043005IDA-neuron projection21957239
GO:0044297ISS-cell body-
GO:0045121IDA-membrane raft21957239
GO:0097447ISS-dendritic tree-
GO ID Evidence Qualifier GO_term References
GO:0003682IEA-chromatin binding-
GO:0003924ISS-GTPase activity-
GO:0003924NAS-GTPase activity8824319
GO:0005515IPI-protein binding21957239
GO:0005516IDA-calmodulin binding8918462
GO:0005516ISS-calmodulin binding-
GO:0005525ISS-GTP binding-
GO:0030215IPI-semaphorin receptor binding16122393
GO:0042802IDANOTidentical protein binding21957239
GO ID Evidence Qualifier GO_term References
GO:0000165ISSNOTMAPK cascade-
GO:0007264NAS-small GTPase mediated signal transduction8824319
GO:0007265ISS-Ras protein signal transduction-
GO:0007268TAS-chemical synaptic transmission8918462
GO:0010976IGI-positive regulation of neuron projection development16157584
GO:0010976ISS-positive regulation of neuron projection development-
GO:0010977IEA-negative regulation of neuron projection development-
GO:0030100IMP-regulation of endocytosis21957239
GO:0032489ISS-regulation of Cdc42 protein signal transduction-
GO:0032507IMP-maintenance of protein location in cell21957239
GO:0035556IDA-intracellular signal transduction21957239
GO:0043410ISS-positive regulation of MAPK cascade-
GO:0045762IEA-positive regulation of adenylate cyclase activity-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0050848ISS-regulation of calcium-mediated signaling-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RIT2CALM11119468824319 Reconstituted Complex
RIT2CALM11072528824319 Reconstituted Complex
RIT2POU4F111194612934100 Reconstituted Complex; Two-hybrid
RIT2POU4F111145312934100 Reconstituted Complex; Two-hybrid
RIT2RAB5A11194611703925 Biochemical Activity
RIT2RAB5A11180611703925 Biochemical Activity
RLFRIT211194610545207 Reconstituted Complex
RLFRIT211195010545207 Reconstituted Complex
SOS1RIT211253712099688 Affinity Capture-Western
SOS1RIT211194612099688 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:108054
  • Data Attributes: MGI curated and HomoloGene calculated
No data