AutismKB 2.0

Annotation Details for BCL6


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Basic Information Top
Gene Symbol:BCL6 ( BCL5,BCL6A,LAZ3,ZBTB27,ZNF51 )
Gene Full Name: B-cell CLL/lymphoma 6
Band: 3q27.3
Quick LinksEntrez ID:604; OMIM: 109565; Uniprot ID:BCL6_HUMAN; ENSEMBL ID: ENSG00000113916; HGNC ID: 1001
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus7795255
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005657IDAcolocalizes_withreplication fork10490843
GO:0005794IDA-Golgi apparatus-
GO ID Evidence Qualifier GO_term References
GO:0000977IEA-RNA polymerase II regulatory region sequence-specific DNA binding-
GO:0001161IEA-intronic transcription regulatory region sequence-specific DNA binding-
GO:0001227IEA-transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0003682IDA-chromatin binding12097386
GO:0003700IMP-transcription factor activity, sequence-specific DNA binding15577913
GO:0005515IPI-protein binding10898795
GO:0031490IEA-chromatin DNA binding-
GO:0042802IPI-identical protein binding25416956
GO:0043565IDA-sequence-specific DNA binding15577913
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000060IGI-protein import into nucleus, translocation11821949
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter11929873
GO:0000902IEA-cell morphogenesis-
GO:0001953IEA-negative regulation of cell-matrix adhesion-
GO:0002467IEA-germinal center formation-
GO:0002634NAS-regulation of germinal center formation7795255
GO:0002903NAS-negative regulation of B cell apoptotic process15577913
GO:0006351IEA-transcription, DNA-templated-
GO:0006954IEA-inflammatory response-
GO:0006974IDA-cellular response to DNA damage stimulus15577913
GO:0007266IEA-Rho protein signal transduction-
GO:0007283IEA-spermatogenesis-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0030036IEA-actin cytoskeleton organization-
GO:0030183IEA-B cell differentiation-
GO:0030308IDA-negative regulation of cell growth10490843
GO:0030890IEA-positive regulation of B cell proliferation-
GO:0031065IEA-positive regulation of histone deacetylation-
GO:0032764IEA-negative regulation of mast cell cytokine production-
GO:0035024IEA-negative regulation of Rho protein signal transduction-
GO:0042092IBA-type 2 immune response-
GO:0042127IBA-regulation of cell proliferation-
GO:0042981TAS-regulation of apoptotic process-
GO:0043065IDA-positive regulation of apoptotic process10490843
GO:0043087IEA-regulation of GTPase activity-
GO:0043380IEA-regulation of memory T cell differentiation-
GO:0045591IMP-positive regulation of regulatory T cell differentiation22387553
GO:0045629IEA-negative regulation of T-helper 2 cell differentiation-
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0045746IEA-negative regulation of Notch signaling pathway-
GO:0045892IMP-negative regulation of transcription, DNA-templated15577913
GO:0045892NAS-negative regulation of transcription, DNA-templated9135990
GO:0048294IEA-negative regulation of isotype switching to IgE isotypes-
GO:0048821IEA-erythrocyte development-
GO:0050727IBA-regulation of inflammatory response-
GO:0050776NAS-regulation of immune response16455075
GO:0051272IEA-positive regulation of cellular component movement-
GO:1903464NAS-negative regulation of mitotic cell cycle DNA replication10490843
GO:2000773IEA-negative regulation of cellular senescence-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HDAC1BCL61070769627120 9753732 10611298 15454082 Affinity Capture-Western; Reconstituted Complex
HDAC1BCL61093159627120 9753732 10611298 15454082 Affinity Capture-Western; Reconstituted Complex
SIN3ABCL61070769753732 9765306 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ABCL61174399753732 9765306 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR2BCL61070769765306 10611298 10898795 11865059 14690607 15454082 15531890 Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid
NCOR2BCL61149749765306 10611298 10898795 11865059 14690607 15454082 15531890 Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid
ZBTB7ABCL61070769927193 Affinity Capture-Western; Two-hybrid
ZBTB7ABCL61194889927193 Affinity Capture-Western; Two-hybrid
IRF4BCL610707610601358 Affinity Capture-Western; Reconstituted Complex
IRF4BCL610987010601358 Affinity Capture-Western; Reconstituted Complex
BCORBCL610707610898795 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCORBCL612022810898795 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR1BCL610707610898795 11865059 15454082 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR1BCL611497310898795 11865059 15454082 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ZBTB16BCL610707611175338 Reconstituted Complex; Two-hybrid
ZBTB16BCL611349811175338 Reconstituted Complex; Two-hybrid
PMLBCL610707611175338 Two-hybrid
PMLBCL611138411175338 Two-hybrid
HDAC5BCL610707611929873 Affinity Capture-Western; Reconstituted Complex
HDAC5BCL611533111929873 Affinity Capture-Western; Reconstituted Complex
HDAC7BCL610707611929873 Affinity Capture-Western; Reconstituted Complex
HDAC7BCL611961311929873 Affinity Capture-Western; Reconstituted Complex
HDAC4BCL610707611929873 Affinity Capture-Western; Reconstituted Complex
HDAC4BCL611510611929873 Affinity Capture-Western; Reconstituted Complex
JUNBBCL610707612165517 Reconstituted Complex
JUNBBCL610992912165517 Reconstituted Complex
JUNDBCL610707612165517 Reconstituted Complex
JUNDBCL610993012165517 Reconstituted Complex
JUNBCL610707612165517 Reconstituted Complex; Two-hybrid
JUNBCL610992812165517 Reconstituted Complex; Two-hybrid
HDAC2BCL610707612402037 Affinity Capture-Western
HDAC2BCL610931612402037 Affinity Capture-Western
EP300BCL610707612402037 Affinity Capture-Western; Biochemical Activity
EP300BCL610834712402037 Affinity Capture-Western; Biochemical Activity
BCL6BBCL612912512659862 Reconstituted Complex; Two-hybrid
BCL6BBCL610707612659862 Reconstituted Complex; Two-hybrid
MBD3BCL610707615454082 Affinity Capture-Western
MBD3BCL611978815454082 Affinity Capture-Western
CHD3BCL610707615454082 Affinity Capture-Western; Reconstituted Complex
CHD3BCL610753215454082 Affinity Capture-Western; Reconstituted Complex
MTA3BCL610707615454082 Affinity Capture-Western; Reconstituted Complex
MTA3BCL612156815454082 Affinity Capture-Western; Reconstituted Complex
BACH2BCL612191318256039 Affinity Capture-Western
BACH2BCL610707618256039 Affinity Capture-Western
SPI1BCL610707619564417 Affinity Capture-Western; Reconstituted Complex
SPI1BCL611256619564417 Affinity Capture-Western; Reconstituted Complex
CREBBPBCL610707621390126 Biochemical Activity
CREBBPBCL610777721390126 Biochemical Activity
Gene Symbol Interactant Interaction ID References Description
MBD3BCL618038015454082 BCL6 interacts with MBD3.
MTA3BCL618036215454082 BCL6 interacts with MTA3.
CHD3BCL618037915454082 BCL6 interacts with Mi2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107187
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7523'