AutismKB 2.0

Annotation Details for ROBO1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ROBO1 ( DUTT1,FLJ21882,MGC131599,MGC133277,SAX3 )
Gene Full Name: roundabout, axon guidance receptor, homolog 1 (Drosophila)
Band: 3p12.3
Quick LinksEntrez ID:6091; OMIM: 602430; Uniprot ID:ROBO1_HUMAN; ENSEMBL ID: ENSG00000169855; HGNC ID: 10249
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm18566128
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane9608531
GO:0009986IDA-cell surface12504588
GO:0030424IEA-axon-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding12504588
GO:0008046TAS-axon guidance receptor activity9458045
GO:0030275IPI-LRR domain binding17848514
GO:0042802IDA-identical protein binding12504588
GO ID Evidence Qualifier GO_term References
GO:0002042IMP-cell migration involved in sprouting angiogenesis19351956
GO:0006919IMP-activation of cysteine-type endopeptidase activity involved in apoptotic process18566128
GO:0007155TAS-cell adhesion9608531
GO:0007156IDA-homophilic cell adhesion via plasma membrane adhesion molecules12504588
GO:0007399TAS-nervous system development9608531
GO:0007411TAS-axon guidance-
GO:0007507IEA-heart development-
GO:0016199ISS-axon midline choice point recognition-
GO:0021836IDA-chemorepulsion involved in postnatal olfactory bulb interneuron migration15207848
GO:0030336IMP-negative regulation of cell migration26529257
GO:0033600IMP-negative regulation of mammary gland epithelial cell proliferation18829537
GO:0035025IMP-positive regulation of Rho protein signal transduction26529257
GO:0035385IMP-Roundabout signaling pathway18829537
GO:0050772IDA-positive regulation of axonogenesis12504588
GO:0050925IDA-negative regulation of negative chemotaxis11748139
GO:0070100IMP-negative regulation of chemokine-mediated signaling pathway18829537
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ROBO1MAPK1410781920936779 Two-hybrid
ROBO1MAPK1411201820936779 Two-hybrid
TUBB3ROBO111565416169070 Two-hybrid
TUBB3ROBO111201816169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1274781
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000209-3'