AutismKB 2.0

Annotation Details for ROCK1


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Basic Information Top
Gene Symbol:ROCK1 ( MGC131603,MGC43611,P160ROCK,PRO0435 )
Gene Full Name: Rho-associated, coiled-coil containing protein kinase 1
Band: 18q11.1
Quick LinksEntrez ID:6093; OMIM: 601702; Uniprot ID:ROCK1_HUMAN; ENSEMBL ID: ENSG00000067900; HGNC ID: 10251
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0001726ISS-ruffle-
GO:0005576TAS-extracellular region-
GO:0005814IEA-centriole-
GO:0005829TAS-cytosol-
GO:0005856ISS-cytoskeleton-
GO:0005886ISS-plasma membrane-
GO:0030027ISS-lamellipodium-
GO:0032059IEA-bleb-
GO:0034774TAS-secretory granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity8798490
GO:0004674IDA-protein serine/threonine kinase activity10652353
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding10652353
GO:0005524IEA-ATP binding-
GO:0017049IEA-GTP-Rho binding-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0003383IEA-apical constriction-
GO:0006468IEA-protein phosphorylation-
GO:0006939TAS-smooth muscle contraction12778124
GO:0007159IDA-leukocyte cell-cell adhesion12082081
GO:0007165TAS-signal transduction10436159
GO:0007249IMP-I-kappaB kinase/NF-kappaB signaling25816133
GO:0007266IEA-Rho protein signal transduction-
GO:0016525IMP-negative regulation of angiogenesis19181962
GO:0022614IDA-membrane to membrane docking12082081
GO:0030036TAS-actin cytoskeleton organization10436159
GO:0030155TAS-regulation of cell adhesion12778124
GO:0030866IGI-cortical actin cytoskeleton organization25816133
GO:0030866IMP-cortical actin cytoskeleton organization25816133
GO:0032060IEA-bleb assembly-
GO:0032091IDA-negative regulation of protein binding18573880
GO:0032956IDA-regulation of actin cytoskeleton organization25911094
GO:0032956TAS-regulation of actin cytoskeleton organization12778124
GO:0035509IGI-negative regulation of myosin-light-chain-phosphatase activity25816133
GO:0035509IMP-negative regulation of myosin-light-chain-phosphatase activity25816133
GO:0043312TAS-neutrophil degranulation-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045616IMP-regulation of keratinocyte differentiation19997641
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0050900IDA-leukocyte migration12082081
GO:0050901IDA-leukocyte tethering or rolling12082081
GO:0051451ISS-myoblast migration-
GO:0051492TAS-regulation of stress fiber assembly12778124
GO:0051893TAS-regulation of focal adhesion assembly12778124
GO:0051894ISS-positive regulation of focal adhesion assembly-
GO:0090002IGI-establishment of protein localization to plasma membrane25816133
GO:0090002IMP-establishment of protein localization to plasma membrane25816133
GO:0097194TAS-execution phase of apoptosis-
GO:1903140IGI-regulation of establishment of endothelial barrier25816133
GO:1903140IMP-regulation of establishment of endothelial barrier25816133
GO:1903347IGI-negative regulation of bicellular tight junction assembly25816133
GO:2000114TAS-regulation of establishment of cell polarity20803696
GO:2000145TAS-regulation of cell motility12778124
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ROCK1RHOA1120208798490 8816443 12773565 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
ROCK1RHOA1068808798490 8816443 12773565 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
ROCK1RND310688312773565 Reconstituted Complex
ROCK1RND311202012773565 Reconstituted Complex
ROCK1CDC25A10742814657354 Biochemical Activity
ROCK1CDC25A11202014657354 Biochemical Activity
ROCK1CFL110749910436159 Affinity Capture-Western
ROCK1CFL111202010436159 Affinity Capture-Western
ROCK1GAB110882412748184 Co-crystal Structure
ROCK1GAB111202012748184 Co-crystal Structure
ROCK1HNRNPA110942017643375 Affinity Capture-MS
ROCK1HNRNPA111202017643375 Affinity Capture-MS
ROCK1LIMK211202010436159 Biochemical Activity
ROCK1LIMK211017310436159 Biochemical Activity
ROCK1PFN211123814517206 Affinity Capture-Western
ROCK1PFN211202014517206 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107927
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100712-2'