AutismKB 2.0

Annotation Details for RORA


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Basic Information Top
Gene Symbol:RORA ( DKFZp686M2414,MGC119326,MGC119329,NR1F1,ROR1,ROR2,ROR3,RZR-ALPHA,RZRA )
Gene Full Name: RAR-related orphan receptor A
Band: 15q22.2
Quick LinksEntrez ID:6095; OMIM: 600825; Uniprot ID:RORA_HUMAN; ENSEMBL ID: ENSG00000069667; HGNC ID: 10258
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus18658046
GO:0005654TAS-nucleoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding19955433
GO:0001046IDA-core promoter sequence-specific DNA binding21628546
GO:0001222IPI-transcription corepressor binding9328355
GO:0001223IPI-transcription coactivator binding9862959
GO:0003677IDA-DNA binding7926749
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding7926749
GO:0003707IEA-steroid hormone receptor activity-
GO:0004879IEA-RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding-
GO:0005515IPI-protein binding14701856
GO:0008013IEA-beta-catenin binding-
GO:0008134IPI-transcription factor binding9862959
GO:0008142IDA-oxysterol binding19965867
GO:0008270IEA-zinc ion binding-
GO:0043565IDA-sequence-specific DNA binding11053433
GO:0098531IDA-transcription factor activity, direct ligand regulated sequence-specific DNA binding19965867
GO ID Evidence Qualifier GO_term References
GO:0001525IMP-angiogenesis18658046
GO:0006355IDA-regulation of transcription, DNA-templated9328355
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006805ISS-xenobiotic metabolic process-
GO:0006809IEA-nitric oxide biosynthetic process-
GO:0008589ISS-regulation of smoothened signaling pathway-
GO:0010575IMP-positive regulation of vascular endothelial growth factor production18658046
GO:0010906ISS-regulation of glucose metabolic process-
GO:0019218ISS-regulation of steroid metabolic process-
GO:0021702IEA-cerebellar Purkinje cell differentiation-
GO:0021930ISS-cerebellar granule cell precursor proliferation-
GO:0030522IDA-intracellular receptor signaling pathway19965867
GO:0032922ISS-circadian regulation of gene expression-
GO:0036315IDA-cellular response to sterol19965867
GO:0036315IMP-cellular response to sterol18658046
GO:0042692IMP-muscle cell differentiation9862959
GO:0042753ISS-positive regulation of circadian rhythm-
GO:0043030IEA-regulation of macrophage activation-
GO:0043124IMP-negative regulation of I-kappaB kinase/NF-kappaB signaling11252722
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0045599ISS-negative regulation of fat cell differentiation-
GO:0045893IDA-positive regulation of transcription, DNA-templated7926749
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter17545671
GO:0046068IEA-cGMP metabolic process-
GO:0050728IMP-negative regulation of inflammatory response11252722
GO:0060850ISS-regulation of transcription involved in cell fate commitment-
GO:0070328IMP-triglyceride homeostasis11053433
GO:0071347IEA-cellular response to interleukin-1-
GO:0071356IEA-cellular response to tumor necrosis factor-
GO:0071456IMP-cellular response to hypoxia18658046
GO:0072539ISS-T-helper 17 cell differentiation-
GO:2000188ISS-regulation of cholesterol homeostasis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RORACEBPB10748019324970 Affinity Capture-Western
RORACEBPB11202219324970 Affinity Capture-Western
RORAEP3001083479862959 Reconstituted Complex; Two-hybrid
RORAEP3001120229862959 Reconstituted Complex; Two-hybrid
RORAMYOD11107379862959 Reconstituted Complex
RORAMYOD11120229862959 Reconstituted Complex
RORANME11120228858107 Reconstituted Complex; Two-hybrid
RORANME11108948858107 Reconstituted Complex; Two-hybrid
RORAPSMC511202216189514 Two-hybrid
RORAPSMC511167816189514 Two-hybrid
C1orf103RORA11202217455211 Reconstituted Complex
C1orf103RORA12090517455211 Reconstituted Complex
RUVBL1RORA11416618087039 Affinity Capture-Western
RUVBL1RORA11202218087039 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104661
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-855'