AutismKB 2.0

Annotation Details for ROS1


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Basic Information Top
Gene Symbol:ROS1 ( MCF3,ROS,c-ros-1 )
Gene Full Name: c-ros oncogene 1 , receptor tyrosine kinase
Band: 6q22.1
Quick LinksEntrez ID:6098; OMIM: 165020; Uniprot ID:ROS_HUMAN; ENSEMBL ID: ENSG00000047936; HGNC ID: 10261
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IEA-plasma membrane-
GO:0009986IEA-cell surface-
GO:0016020TAS-membrane3785223
GO:0016021IEA-integral component of membrane-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004713IDA-protein tyrosine kinase activity16885344
GO:0004714IEA-transmembrane receptor protein tyrosine kinase activity-
GO:0005515IPI-protein binding17416557
GO:0005524IEA-ATP binding-
GO:0019903IPI-protein phosphatase binding16885344
GO ID Evidence Qualifier GO_term References
GO:0002066ISS-columnar/cuboidal epithelial cell development-
GO:0006468IDA-protein phosphorylation16885344
GO:0007169IEA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007283ISS-spermatogenesis-
GO:0008283ISS-cell proliferation-
GO:0010629IEA-negative regulation of gene expression-
GO:0010966IEA-regulation of phosphate transport-
GO:0016049IDA-cell growth16885344
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030154ISS-cell differentiation-
GO:0032006IDA-regulation of TOR signaling16885344
GO:0038083IEA-peptidyl-tyrosine autophosphorylation-
GO:0070372ISS-regulation of ERK1 and ERK2 cascade-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ROS1EGFR11202511094073 Affinity Capture-Western
ROS1EGFR10827611094073 Affinity Capture-Western
ROS1PTPN611174211266449 Affinity Capture-Western; Biochemical Activity; Two-hybrid
ROS1PTPN611202511266449 Affinity Capture-Western; Biochemical Activity; Two-hybrid
ROS1PTPN1111202511266449 Two-hybrid
ROS1PTPN1111174511266449 Two-hybrid
VAV3ROS111571511094073 Affinity Capture-Western
VAV3ROS111202511094073 Affinity Capture-Western
IKBKGROS111408920098747 Reconstituted Complex
IKBKGROS111202520098747 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97999
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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