AutismKB 2.0

Annotation Details for HCN2


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Basic Information Top
Gene Symbol:HCN2 ( BCNG-2,BCNG2,HAC-1 )
Gene Full Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Band: 19p13.3
Quick LinksEntrez ID:610; OMIM: 602781; Uniprot ID:HCN2_HUMAN; ENSEMBL ID: ENSG00000099822; HGNC ID: 4846
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane22748890
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane10228147
GO:0008076TAS-voltage-gated potassium channel complex9630217
GO:0098855IDA-HCN channel complex10228147
GO ID Evidence Qualifier GO_term References
GO:0005222IDA-intracellular cAMP activated cation channel activity10228147
GO:0005248IMP-voltage-gated sodium channel activity22748890
GO:0005249IDA-voltage-gated potassium channel activity10228147
GO:0005249IMP-voltage-gated potassium channel activity22748890
GO:0030552IEA-cAMP binding-
GO:0042802IPI-identical protein binding22006928
GO ID Evidence Qualifier GO_term References
GO:0007267TAS-cell-cell signaling9630217
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0035725IMP-sodium ion transmembrane transport22748890
GO:0042391IMP-regulation of membrane potential22748890
GO:0060078IEA-regulation of postsynaptic membrane potential-
GO:0071320IDA-cellular response to cAMP10228147
GO:0071321IDA-cellular response to cGMP22748890
GO:0071805IDA-potassium ion transmembrane transport10228147
GO:0071805IMP-potassium ion transmembrane transport22748890
GO:0086012IC-membrane depolarization during cardiac muscle cell action potential10228147
GO:0098719IDA-sodium ion import across plasma membrane10228147
GO:1990573IDA-potassium ion import across plasma membrane10228147
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HCN1HCN213154312034718 12928435 Affinity Capture-Western; Two-hybrid
HCN1HCN210708112034718 12928435 Affinity Capture-Western; Two-hybrid
HCN2HCN210708112034718 Two-hybrid
HCN4HCN210708112928435 Affinity Capture-Western
HCN4HCN211533812928435 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1298210
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-8228'