AutismKB 2.0

Annotation Details for BCR


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Basic Information Top
Gene Symbol:BCR ( ALL,BCR1,CML,D22S11,D22S662,FLJ16453,PHL )
Gene Full Name: breakpoint cluster region
Band: 22q11.23
Quick LinksEntrez ID:613; OMIM: 151410; Uniprot ID:BCR_HUMAN; ENSEMBL ID: ENSG00000186716; HGNC ID: 1014
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0014069ISS-postsynaptic density-
GO:0016020IBA-membrane-
GO:0016020IDA-membrane19946888
GO:0030054IEA-cell junction-
GO:0043234IDA-protein complex23382219
GO:0045211IEA-postsynaptic membrane-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004674IEA-protein serine/threonine kinase activity-
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005089IEA-Rho guanyl-nucleotide exchange factor activity-
GO:0005096IBA-GTPase activator activity-
GO:0005096TAS-GTPase activator activity-
GO:0005515IPI-protein binding8112292
GO:0005524IEA-ATP binding-
GO:0016301TAS-kinase activity-
GO:0019899IEA-enzyme binding-
GO ID Evidence Qualifier GO_term References
GO:0002692IEA-negative regulation of cellular extravasation-
GO:0003014IEA-renal system process-
GO:0006468TAS-protein phosphorylation1657398
GO:0007165TAS-signal transduction1657398
GO:0007420IEA-brain development-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030036IEA-actin cytoskeleton organization-
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0035556IEA-intracellular signal transduction-
GO:0042472IEA-inner ear morphogenesis-
GO:0043114IEA-regulation of vascular permeability-
GO:0043314IEA-negative regulation of neutrophil degranulation-
GO:0043547IBA-positive regulation of GTPase activity-
GO:0046777IEA-protein autophosphorylation-
GO:0048008IEA-platelet-derived growth factor receptor signaling pathway-
GO:0048872IEA-homeostasis of number of cells-
GO:0050728IEA-negative regulation of inflammatory response-
GO:0050766IEA-positive regulation of phagocytosis-
GO:0050885IEA-neuromuscular process controlling balance-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0051171IEA-regulation of nitrogen compound metabolic process-
GO:0051726IEA-regulation of cell cycle-
GO:0060216IEA-definitive hemopoiesis-
GO:0060268IEA-negative regulation of respiratory burst-
GO:0060313IEA-negative regulation of blood vessel remodeling-
GO:0065002IEA-intracellular protein transmembrane transport-
GO:0071222IEA-cellular response to lipopolysaccharide-
GO:2000378IEA-negative regulation of reactive oxygen species metabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BCRABL11065431712671 8112292 12543778 Affinity Capture-Western; Reconstituted Complex
BCRABL11070831712671 8112292 12543778 Affinity Capture-Western; Reconstituted Complex
BCRRHOA1068809535855 Reconstituted Complex
BCRRHOA1070839535855 Reconstituted Complex
SOS1BCR1125377529874 8112292 Affinity Capture-Western
SOS1BCR1070837529874 8112292 Affinity Capture-Western
GRB2BCR1070837529874 8112292 9178913 9747873 10887132 15143164 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
GRB2BCR1091427529874 8112292 9178913 9747873 10887132 15143164 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
FESBCR1070837529874 10706130 Affinity Capture-Western; Reconstituted Complex
FESBCR1085337529874 10706130 Affinity Capture-Western; Reconstituted Complex
PXNBCR1070837534286 8641358 Affinity Capture-Western; Co-purification
PXNBCR1117877534286 8641358 Affinity Capture-Western; Co-purification
PIK3CGBCR1113127606002 8641358 9747873 Affinity Capture-Western; Co-purification; Two-hybrid
PIK3CGBCR1070837606002 8641358 9747873 Affinity Capture-Western; Co-purification; Two-hybrid
TLN1BCR1129498641358 Co-purification
TLN1BCR1070838641358 Co-purification
CBLBCR1070838641358 Co-purification
CBLBCR1073158641358 Co-purification
KITBCR1100158757502 Affinity Capture-Western
KITBCR1070838757502 Affinity Capture-Western
CRKLBCR1070838978305 9747873 10194128 15143164 Affinity Capture-Western; Far Western; Two-hybrid
CRKLBCR1077898978305 9747873 10194128 15143164 Affinity Capture-Western; Far Western; Two-hybrid
RB1BCR1070839071815 Affinity Capture-Western
RB1BCR1118609071815 Affinity Capture-Western
IL3BCR1070839209414 Affinity Capture-Western
IL3BCR1097779209414 Affinity Capture-Western
RAC1BCR1070839535855 Reconstituted Complex
RAC1BCR1118179535855 Reconstituted Complex
CDC42BCR1070839535855 Reconstituted Complex
CDC42BCR1074339535855 Reconstituted Complex
GRB10BCR1091449747873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRB10BCR1070839747873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PTPN6BCR1070839788431 Affinity Capture-Western
PTPN6BCR1117429788431 Affinity Capture-Western
ERCC3BCR1070839874796 17643375 Affinity Capture-MS; Far Western; Two-hybrid
ERCC3BCR1083839874796 17643375 Affinity Capture-MS; Far Western; Two-hybrid
HCKBCR10930510849448 12592324 Affinity Capture-Western
HCKBCR10708310849448 12592324 Affinity Capture-Western
HOXA9BCR10944512393433 Phenotypic Enhancement
HOXA9BCR10708312393433 Phenotypic Enhancement
MLLT4BCR11044712808105 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MLLT4BCR10708312808105 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
GAB2BCR10708315143164 Affinity Capture-Western
GAB2BCR11518115143164 Affinity Capture-Western
TP53BCR11301016169070 Two-hybrid
TP53BCR10708316169070 Two-hybrid
IGSF21BCR10708316169070 Two-hybrid
IGSF21BCR12439616169070 Two-hybrid
UNC119BCR11454816169070 Two-hybrid
UNC119BCR10708316169070 Two-hybrid
VPS28BCR11934116778200 Affinity Capture-Western
VPS28BCR10708316778200 Affinity Capture-Western
TSG101BCR11310216778200 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TSG101BCR10708316778200 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WDR48BCR12164919615732 Affinity Capture-MS
WDR48BCR10708319615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
BCRrs9608099 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:88141
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040724-43'