AutismKB 2.0

Annotation Details for RPS6KA1


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Basic Information Top
Gene Symbol:RPS6KA1 ( HU-1,MAPKAPK1A,RSK,RSK1 )
Gene Full Name: ribosomal protein S6 kinase, 90kDa, polypeptide 1
Band: 1p36.11
Quick LinksEntrez ID:6195; OMIM: 601684; Uniprot ID:KS6A1_HUMAN; ENSEMBL ID: ENSG00000117676; HGNC ID: 10430
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005634IDA-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737IBA-cytoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0000287IEA-magnesium ion binding-
GO:0004674IDA-protein serine/threonine kinase activity10679322
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004712IDA-protein serine/threonine/tyrosine kinase activity22797923
GO:0005515IPI-protein binding21423205
GO:0005524IEA-ATP binding-
GO:0016301TAS-kinase activity-
GO:0043027IDA-cysteine-type endopeptidase inhibitor activity involved in apoptotic process18402937
GO ID Evidence Qualifier GO_term References
GO:0006468IEA-protein phosphorylation-
GO:0006915IEA-apoptotic process-
GO:0007049IEA-cell cycle-
GO:0007165TAS-signal transduction8141249
GO:0030307TAS-positive regulation of cell growth18813292
GO:0035556IBA-intracellular signal transduction-
GO:0043066IMP-negative regulation of apoptotic process11684016
GO:0043154IDA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process18402937
GO:0043555TAS-regulation of translation in response to stress18813292
GO:0043620TAS-regulation of DNA-templated transcription in response to stress18813292
GO:0045597TAS-positive regulation of cell differentiation18813292
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter22065586
GO:0072574ISS-hepatocyte proliferation-
GO:2000491IMP-positive regulation of hepatic stellate cell activation10679322
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RPS6KA1BAD10704811500364 Reconstituted Complex
RPS6KA1BAD11210911500364 Reconstituted Complex
RPS6KA1CREBBP10777715929978 Affinity Capture-Western
RPS6KA1CREBBP11210915929978 Affinity Capture-Western
RPS6KA1ESR11084039528769 Biochemical Activity
RPS6KA1ESR11121099528769 Biochemical Activity
RPS6KA1NFKBIA1108599214631 Affinity Capture-Western; Biochemical Activity
RPS6KA1NFKBIA1121099214631 Affinity Capture-Western; Biochemical Activity
RPS6KA1MAPK11115809915826 12594221 12832467 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPS6KA1MAPK11121099915826 12594221 12832467 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPS6KA1MAPK311158112832467 Affinity Capture-Western
RPS6KA1MAPK311210912832467 Affinity Capture-Western
TOB1RPS6KA111544311260258 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TOB1RPS6KA111210911260258 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EEF2KRPS6KA111895311500364 Reconstituted Complex
EEF2KRPS6KA111210911500364 Reconstituted Complex
YWHABRPS6KA111336112618428 Affinity Capture-Western; Reconstituted Complex
YWHABRPS6KA111210912618428 Affinity Capture-Western; Reconstituted Complex
TSC1RPS6KA111309915342917 Affinity Capture-Western
TSC1RPS6KA111210915342917 Affinity Capture-Western
TSC2RPS6KA111310015342917 15757502 Affinity Capture-Western; Reconstituted Complex
TSC2RPS6KA111210915342917 15757502 Affinity Capture-Western; Reconstituted Complex
CARHSP1RPS6KA111712415910284 Reconstituted Complex
CARHSP1RPS6KA111210915910284 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
RPS6KA1FGFR121506015117958 FGFR1 interacts with RSK1. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RSK1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104558
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060929-516'