AutismKB 2.0

Annotation Details for RPS6KB1


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Basic Information Top
Gene Symbol:RPS6KB1 ( PS6K,S6K,S6K1,STK14A,p70(S6K)-alpha,p70-S6K,p70-alpha )
Gene Full Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1
Band: 17q23.1
Quick LinksEntrez ID:6198; OMIM: 608938; Uniprot ID:KS6B1_HUMAN; ENSEMBL ID: ENSG00000108443; HGNC ID: 10436
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005739IDA-mitochondrion17936702
GO:0005741IEA-mitochondrial outer membrane-
GO:0005829TAS-cytosol-
GO:0009986IEA-cell surface-
GO:0030054IEA-cell junction-
GO:0043005IEA-neuron projection-
GO:0045202IEA-synapse-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity17936702
GO:0004674IBA-protein serine/threonine kinase activity-
GO:0004711IEA-ribosomal protein S6 kinase activity-
GO:0004712IDA-protein serine/threonine/tyrosine kinase activity22797923
GO:0005515IPI-protein binding11438723
GO:0005524IEA-ATP binding-
GO:0016301TAS-kinase activity-
GO:0030165IEA-PDZ domain binding-
GO:0042277IEA-peptide binding-
GO:0042802IEA-identical protein binding-
GO:0051721IEA-protein phosphatase 2A binding-
GO ID Evidence Qualifier GO_term References
GO:0000082IMP-G1/S transition of mitotic cell cycle14673156
GO:0001662IEA-behavioral fear response-
GO:0003009IEA-skeletal muscle contraction-
GO:0006468IEA-protein phosphorylation-
GO:0006915IEA-apoptotic process-
GO:0007165TAS-signal transduction1922062
GO:0007281IEA-germ cell development-
GO:0007568IEA-aging-
GO:0007584IEA-response to nutrient-
GO:0007616IEA-long-term memory-
GO:0009408IEA-response to heat-
GO:0009611IEA-response to wounding-
GO:0009612IEA-response to mechanical stimulus-
GO:0009636IEA-response to toxic substance-
GO:0009749IEA-response to glucose-
GO:0014732IEA-skeletal muscle atrophy-
GO:0014878IEA-response to electrical stimulus involved in regulation of muscle adaptation-
GO:0014911IEA-positive regulation of smooth muscle cell migration-
GO:0016477IEA-cell migration-
GO:0031929IDA-TOR signaling12150926
GO:0032496IEA-response to lipopolysaccharide-
GO:0032868IEA-response to insulin-
GO:0033574IEA-response to testosterone-
GO:0033762IEA-response to glucagon-
GO:0034612IEA-response to tumor necrosis factor-
GO:0042493IEA-response to drug-
GO:0043066IMP-negative regulation of apoptotic process17936702
GO:0043201IEA-response to leucine-
GO:0043491IEA-protein kinase B signaling-
GO:0045471IEA-response to ethanol-
GO:0045727IMP-positive regulation of translation18423201
GO:0045931IMP-positive regulation of mitotic cell cycle14673156
GO:0045948IMP-positive regulation of translational initiation16763566
GO:0046324IEA-regulation of glucose import-
GO:0046627IMP-negative regulation of insulin receptor signaling pathway18952604
GO:0048015TAS-phosphatidylinositol-mediated signaling9445476
GO:0048633IEA-positive regulation of skeletal muscle tissue growth-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0071363IDA-cellular response to growth factor stimulus17936702
GO:0071549IEA-cellular response to dexamethasone stimulus-
GO:2001237IEA-negative regulation of extrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RPS6KB1ACTA111211215149849 Reconstituted Complex
RPS6KB1ACTA110657315149849 Reconstituted Complex
RPS6KB1AKT111211215149849 Co-purification
RPS6KB1AKT110671015149849 Co-purification
RPS6KB1BTK10716016640565 Biochemical Activity
RPS6KB1BTK11211216640565 Biochemical Activity
RPS6KB1CSNK2A110784116895915 Reconstituted Complex
RPS6KB1CSNK2A111211216895915 Reconstituted Complex
RPS6KB1CSNK2B11211216895915 Affinity Capture-Western; Reconstituted Complex
RPS6KB1CSNK2B10784316895915 Affinity Capture-Western; Reconstituted Complex
RPS6KB1MTOR1121129465032 10567431 10971657 11914378 12150925 12150926 12604610 14679009 15809305 15854902 15896331 15899889 15905173 16183647 16922504 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPS6KB1MTOR1087579465032 10567431 10971657 11914378 12150925 12150926 12604610 14679009 15809305 15854902 15896331 15899889 15905173 16183647 16922504 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPS6KB1GDI2P111211215249583 16914728 Biochemical Activity; Reconstituted Complex
RPS6KB1GDI2P110893515249583 16914728 Biochemical Activity; Reconstituted Complex
RPS6KB1LYN11024516640565 Biochemical Activity
RPS6KB1LYN11211216640565 Biochemical Activity
RPS6KB1PDK111118911733037 Reconstituted Complex
RPS6KB1PDK111211211733037 Reconstituted Complex
RPS6KB1PPP2R2A11151210200280 16899564 Affinity Capture-Western
RPS6KB1PPP2R2A11211210200280 16899564 Affinity Capture-Western
RPS6KB1PRKCZ11211216931574 Affinity Capture-Western
RPS6KB1PRKCZ11157616931574 Affinity Capture-Western
EEF2KRPS6KB111211211500364 Reconstituted Complex
EEF2KRPS6KB111895311500364 Reconstituted Complex
RPTORRPS6KB112158212150926 12604610 15809305 16837165 Affinity Capture-Western; Reconstituted Complex
RPTORRPS6KB111211212150926 12604610 15809305 16837165 Affinity Capture-Western; Reconstituted Complex
TRAF4RPS6KB111497912801526 Affinity Capture-Western
TRAF4RPS6KB111211212801526 Affinity Capture-Western
POLDIP3RPS6KB112399815341740 Affinity Capture-Western; Biochemical Activity; Two-hybrid
POLDIP3RPS6KB111211215341740 Affinity Capture-Western; Biochemical Activity; Two-hybrid
COASYRPS6KB112325415589845 Affinity Capture-Western; Reconstituted Complex
COASYRPS6KB111211215589845 Affinity Capture-Western; Reconstituted Complex
RICTORRPS6KB111211215809305 Reconstituted Complex
RICTORRPS6KB112896215809305 Reconstituted Complex
TERTRPS6KB111211215843522 Affinity Capture-Western
TERTRPS6KB111287415843522 Affinity Capture-Western
EIF3FRPS6KB111211216286006 Affinity Capture-MS
EIF3FRPS6KB111421416286006 Affinity Capture-MS
EIF3BRPS6KB111421116286006 Affinity Capture-Western
EIF3BRPS6KB111211216286006 Affinity Capture-Western
EIF3CRPS6KB111421216286006 Affinity Capture-Western
EIF3CRPS6KB111211216286006 Affinity Capture-Western
SRCRPS6KB111259216640565 Biochemical Activity
SRCRPS6KB111211216640565 Biochemical Activity
SYKRPS6KB111211216640565 Biochemical Activity
SYKRPS6KB111271716640565 Biochemical Activity
XPO1RPS6KB111211216895915 Affinity Capture-Western
XPO1RPS6KB111334816895915 Affinity Capture-Western
UBCRPS6KB111211218279656 Affinity Capture-Western
UBCRPS6KB111316418279656 Affinity Capture-Western
RBX1RPS6KB111530118279656 Affinity Capture-Western; Reconstituted Complex
RBX1RPS6KB111211218279656 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2038'