AutismKB 2.0

Annotation Details for RXRA


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Basic Information Top
Gene Symbol:RXRA ( FLJ00280,FLJ00318,FLJ16020,FLJ16733,MGC102720,NR2B1 )
Gene Full Name: retinoid X receptor, alpha
Band: 9q34.2
Quick LinksEntrez ID:6256; OMIM: 180245; Uniprot ID:RXRA_HUMAN; ENSEMBL ID: ENSG00000186350; HGNC ID: 10477
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin18511497
GO:0005634IDA-nucleus7990953
GO:0005654TAS-nucleoplasm-
GO:0043234IDA-protein complex19043829
GO:0043235IDA-receptor complex17426122
GO:0090575IDA-RNA polymerase II transcription factor complex17426122
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding7831303
GO:0001972IDA-retinoic acid binding19043829
GO:0003677IDA-DNA binding12037571
GO:0003690IMP-double-stranded DNA binding19043829
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding12037571
GO:0003700IDAcontributes_totranscription factor activity, sequence-specific DNA binding17426122
GO:0003707IEA-steroid hormone receptor activity-
GO:0003708TAS-retinoic acid receptor activity19374686
GO:0003713TAS-transcription coactivator activity1651173
GO:0004879IDA-RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding7990953
GO:0004886IEA-9-cis retinoic acid receptor activity-
GO:0005515IPI-protein binding9653119
GO:0008270IDA-zinc ion binding19043829
GO:0016922IPI-ligand-dependent nuclear receptor binding19043829
GO:0019899IPI-enzyme binding12039952
GO:0031490IEA-chromatin DNA binding-
GO:0042277IDA-peptide binding19043829
GO:0042809IPI-vitamin D receptor binding17426122
GO:0043565IDA-sequence-specific DNA binding11915042
GO:0044212IDAcontributes_totranscription regulatory region DNA binding18511497
GO:0044323IDA-retinoic acid-responsive element binding19917671
GO:0046982IDA-protein heterodimerization activity19043829
GO:0050692IDA-DBD domain binding19043829
GO:0050693IDA-LBD domain binding19043829
GO:0070644IDAcontributes_tovitamin D response element binding17426122
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter17426122
GO:0001701IEA-in utero embryonic development-
GO:0001893IEA-maternal placenta development-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006766TAS-vitamin metabolic process1651173
GO:0007566IEA-embryo implantation-
GO:0008203TAS-cholesterol metabolic process19374686
GO:0015721TAS-bile acid and bile salt transport-
GO:0019048IDA-modulation by virus of host morphology or physiology11915042
GO:0019216TAS-regulation of lipid metabolic process-
GO:0032526IMP-response to retinoic acid17538076
GO:0035357IDA-peroxisome proliferator activated receptor signaling pathway10195690
GO:0043010IEA-camera-type eye development-
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter12037571
GO:0045994IEA-positive regulation of translational initiation by iron-
GO:0048384IMP-retinoic acid receptor signaling pathway17538076
GO:0051289IDA-protein homotetramerization7831303
GO:0055010IEA-ventricular cardiac muscle tissue morphogenesis-
GO:0055012IEA-ventricular cardiac muscle cell differentiation-
GO:0060038IEA-cardiac muscle cell proliferation-
GO:0060528IEA-secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development-
GO:0060687IEA-regulation of branching involved in prostate gland morphogenesis-
GO:1901522IEA-positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RXRAARNTL10689911439184 Reconstituted Complex
RXRAARNTL11216811439184 Reconstituted Complex
RXRABCL31070749812988 Reconstituted Complex; Two-hybrid
RXRABCL31121689812988 Reconstituted Complex; Two-hybrid
RXRACTNNB110788012771132 Affinity Capture-Western
RXRACTNNB111216812771132 Affinity Capture-Western
RXRACTSL11078949837884 Biochemical Activity
RXRACTSL11121689837884 Biochemical Activity
RXRAGADD45A10801410872826 Affinity Capture-Western
RXRAGADD45A11216810872826 Affinity Capture-Western
RXRANR2F610837510318855 Two-hybrid
RXRANR2F611216810318855 Two-hybrid
RXRAFUS1087979440806 Reconstituted Complex
RXRAFUS1121689440806 Reconstituted Complex
RXRANR4A110940714980220 Reconstituted Complex; Two-hybrid
RXRANR4A111216814980220 Reconstituted Complex; Two-hybrid
RXRAIGFBP310970710874028 Affinity Capture-Western; Reconstituted Complex
RXRAIGFBP311216810874028 Affinity Capture-Western; Reconstituted Complex
RXRAMYOD11107379692544 Reconstituted Complex
RXRAMYOD11121689692544 Reconstituted Complex
RXRANFKB111085710075655 Reconstituted Complex
RXRANFKB111216810075655 Reconstituted Complex
RXRANFKBIB1108609452433 Reconstituted Complex; Two-hybrid
RXRANFKBIB1121689452433 Reconstituted Complex; Two-hybrid
RXRANPAS211092311439184 Reconstituted Complex; Two-hybrid
RXRANPAS211216811439184 Reconstituted Complex; Two-hybrid
RXRAPML11138410610177 Reconstituted Complex
RXRAPML11216810610177 Reconstituted Complex
RXRAPOLR2A11142615863722 Co-localization
RXRAPOLR2A11216815863722 Co-localization
RXRAPOU2F111144710383413 10480874 Reconstituted Complex
RXRAPOU2F111216810383413 10480874 Reconstituted Complex
RXRAPOU2F211144810383413 Reconstituted Complex
RXRAPOU2F211216810383413 Reconstituted Complex
RXRAPPARA11146110195690 Reconstituted Complex
RXRAPPARA11216810195690 Reconstituted Complex
RXRAPPARG1114647838715 10854698 10882139 Co-crystal Structure; Co-purification; Reconstituted Complex
RXRAPPARG1121687838715 10854698 10882139 Co-crystal Structure; Co-purification; Reconstituted Complex
RXRAMED111146510935544 11027271 15863722 Co-localization; Reconstituted Complex; Two-hybrid
RXRAMED111216810935544 11027271 15863722 Co-localization; Reconstituted Complex; Two-hybrid
RXRARARA1118491314167 9415406 12052862 15171703 15528208 Affinity Capture-Western; Co-crystal Structure; Co-purification; Far Western; Reconstituted Complex
RXRARARA1121681314167 9415406 12052862 15171703 15528208 Affinity Capture-Western; Co-crystal Structure; Co-purification; Far Western; Reconstituted Complex
RXRARARB11185015528208 Co-crystal Structure
RXRARARB11216815528208 Co-crystal Structure
RXRARELA11190210075655 Reconstituted Complex
RXRARELA11216810075655 Reconstituted Complex
THRARXRA1129231314167 11117530 Affinity Capture-Western; Co-purification
THRARXRA1121681314167 11117530 Affinity Capture-Western; Co-purification
TBPRXRA1127717667283 Reconstituted Complex; Two-hybrid
TBPRXRA1121687667283 Reconstituted Complex; Two-hybrid
NR1H2RXRA1121687760852 Reconstituted Complex; Two-hybrid
NR1H2RXRA1132227760852 Reconstituted Complex; Two-hybrid
NR1H4RXRA1152967760852 Reconstituted Complex; Two-hybrid
NR1H4RXRA1121687760852 Reconstituted Complex; Two-hybrid
NR1I3RXRA1152958114692 Reconstituted Complex
NR1I3RXRA1121688114692 Reconstituted Complex
NR1H3RXRA1153738621574 Reconstituted Complex
NR1H3RXRA1121688621574 Reconstituted Complex
NRIP1RXRA1138438887632 12549917 Reconstituted Complex
NRIP1RXRA1121688887632 12549917 Reconstituted Complex
TRIM24RXRA1143339115274 11851396 Reconstituted Complex
TRIM24RXRA1121689115274 11851396 Reconstituted Complex
THRBRXRA1121689171239 9368056 9415406 19211732 Far Western; Reconstituted Complex; Two-hybrid
THRBRXRA1129249171239 9368056 9415406 19211732 Far Western; Reconstituted Complex; Two-hybrid
NCOA1RXRA1142009171239 10082574 10935544 11027271 Far Western; Reconstituted Complex; Two-hybrid
NCOA1RXRA1121689171239 10082574 10935544 11027271 Far Western; Reconstituted Complex; Two-hybrid
NCOA3RXRA1138419267036 11027271 11851396 15863722 Co-localization; Reconstituted Complex
NCOA3RXRA1121689267036 11027271 11851396 15863722 Co-localization; Reconstituted Complex
NCOR2RXRA1149749415406 9878542 10082574 Reconstituted Complex; Two-hybrid
NCOR2RXRA1121689415406 9878542 10082574 Reconstituted Complex; Two-hybrid
VDRRXRA1132649632709 10037600 10224118 10733574 11075811 11149488 11514567 14726489 15647825 15805579 15890193 16357103 17786964 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
VDRRXRA1121689632709 10037600 10224118 10733574 11075811 11149488 11514567 14726489 15647825 15805579 15890193 16357103 17786964 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
MED24RXRA1151969653119 Reconstituted Complex
MED24RXRA1121689653119 Reconstituted Complex
SP1RXRA11255010361124 18270252 Affinity Capture-Western; Reconstituted Complex
SP1RXRA11216810361124 18270252 Affinity Capture-Western; Reconstituted Complex
ITGB3BPRXRA11216810490654 Reconstituted Complex; Two-hybrid
ITGB3BPRXRA11699210490654 Reconstituted Complex; Two-hybrid
SRCRXRA11259210517671 15116119 15140878 Reconstituted Complex
SRCRXRA11216810517671 15116119 15140878 Reconstituted Complex
BRD8RXRA11610810517671 Reconstituted Complex; Two-hybrid
BRD8RXRA11216810517671 Reconstituted Complex; Two-hybrid
NCOA6RXRA11216810567404 11158331 11773444 14578865 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA6RXRA11669110567404 11158331 11773444 14578865 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR0B2RXRA11401210594021 12198243 Reconstituted Complex; Two-hybrid
NR0B2RXRA11216810594021 12198243 Reconstituted Complex; Two-hybrid
NR2E3RXRA11532010611353 Reconstituted Complex
NR2E3RXRA11216810611353 Reconstituted Complex
NRBF2RXRA11900910786636 Two-hybrid
NRBF2RXRA11216810786636 Two-hybrid
GADD45GRXRA11611710872826 Reconstituted Complex
GADD45GRXRA11216810872826 Reconstituted Complex
GRIP1RXRA11216811027271 Reconstituted Complex
GRIP1RXRA11699511027271 Reconstituted Complex
CLOCKRXRA11494411439184 Reconstituted Complex; Two-hybrid
CLOCKRXRA11216811439184 Reconstituted Complex; Two-hybrid
NCOA2RXRA11576111514567 11851396 15657427 Reconstituted Complex
NCOA2RXRA11216811514567 11851396 15657427 Reconstituted Complex
SNW1RXRA11659711514567 Reconstituted Complex
SNW1RXRA11216811514567 Reconstituted Complex
PPARGC1ARXRA11609711714715 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPARGC1ARXRA11216811714715 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EDF1RXRA11426012040021 Reconstituted Complex
EDF1RXRA11216812040021 Reconstituted Complex
TADA3RXRA11573712235159 Affinity Capture-Western; Reconstituted Complex
TADA3RXRA11216812235159 Affinity Capture-Western; Reconstituted Complex
TAF1BRXRA11448312511607 Reconstituted Complex
TAF1BRXRA11216812511607 Reconstituted Complex
TDGRXRA11216812874288 Reconstituted Complex
TDGRXRA11285512874288 Reconstituted Complex
HDAC3RXRA11436812943985 Reconstituted Complex
HDAC3RXRA11216812943985 Reconstituted Complex
HDAC4RXRA11216812943985 Reconstituted Complex
HDAC4RXRA11510612943985 Reconstituted Complex
RNF8RXRA11449214981089 FRET; Reconstituted Complex; Two-hybrid
RNF8RXRA11216814981089 FRET; Reconstituted Complex; Two-hybrid
DNTTIP2RXRA11905215047147 Reconstituted Complex
DNTTIP2RXRA11216815047147 Reconstituted Complex
NCOR1RXRA11497315116119 Reconstituted Complex
NCOR1RXRA11216815116119 Reconstituted Complex
SMARCA4RXRA11248115774904 Affinity Capture-Western
SMARCA4RXRA11216815774904 Affinity Capture-Western
UBQLN4RXRA12122316169070 Two-hybrid
UBQLN4RXRA11216816169070 Two-hybrid
TMPRSS3RXRA12223616169070 Two-hybrid
TMPRSS3RXRA11216816169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
RXRARXRA_IVS8, rs1536475, rs1805343, rs1805352, rs2266677, rs3118570, rs3132293 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:98214
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070314-2'