AutismKB 2.0

Annotation Details for RYK


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Basic Information Top
Gene Symbol:RYK ( D3S3195,JTK5,JTK5A,RYK1 )
Gene Full Name: RYK receptor-like tyrosine kinase
Band: 3q22.2
Quick LinksEntrez ID:6259; OMIM: 600524; Uniprot ID:RYK_HUMAN; ENSEMBL ID: ENSG00000163785; HGNC ID: 10481
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005634NAS-nucleus20004982
GO:0005737ISS-cytoplasm-
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane8386829
GO:0016020ISS-membrane-
GO:0016021NAS-integral component of membrane8726462
GO ID Evidence Qualifier GO_term References
GO:0004713IDANOTprotein tyrosine kinase activity10454588
GO:0004888IDA-transmembrane signaling receptor activity10454588
GO:0005109ISS-frizzled binding-
GO:0005109NAS-frizzled binding20004982
GO:0005515IPI-protein binding15454084
GO:0005524IEA-ATP binding-
GO:0017147ISS-Wnt-protein binding-
GO:0017147NAS-Wnt-protein binding20004982
GO:0042813ISS-Wnt-activated receptor activity-
GO:1904929TAS-coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway24431302
GO ID Evidence Qualifier GO_term References
GO:0006468IDANOTprotein phosphorylation10454588
GO:0007165TAS-signal transduction8386829
GO:0007409ISS-axonogenesis-
GO:0007409TAS-axonogenesis24431302
GO:0007411ISS-axon guidance-
GO:0007411NAS-axon guidance20004982
GO:0007416NAS-synapse assembly20004982
GO:0016055TAS-Wnt signaling pathway-
GO:0022008NAS-neurogenesis20004982
GO:0022038ISS-corpus callosum development-
GO:0030182ISS-neuron differentiation-
GO:0031175ISS-neuron projection development-
GO:0033278ISS-cell proliferation in midbrain-
GO:0035567NAS-non-canonical Wnt signaling pathway20004982
GO:0036518ISS-chemorepulsion of dopaminergic neuron axon-
GO:0043410IDA-positive regulation of MAPK cascade10454588
GO:0060070NAS-canonical Wnt signaling pathway20004982
GO:0071679ISS-commissural neuron axon guidance-
GO:1904938ISS-planar cell polarity pathway involved in axon guidance-
GO:1904948ISS-midbrain dopaminergic neuron differentiation-
GO:1904953ISS-Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation-
GO:1904953TAS-Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation24431302
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RYKEPHB211217111956217 Affinity Capture-Western
RYKEPHB210836211956217 Affinity Capture-Western
RYKEPHB311217111956217 Affinity Capture-Western
RYKEPHB310836311956217 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:101766
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070209-277'