AutismKB 2.0

Annotation Details for S100A8


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Basic Information Top
Gene Symbol:S100A8 ( 60B8AG,CAGA,CFAG,CGLA,CP-10,L1Ag,MA387,MIF,MRP8,NIF,P8 )
Gene Full Name: S100 calcium binding protein A8
Band: 1q21.3
Quick LinksEntrez ID:6279; OMIM: 123885; Uniprot ID:S10A8_HUMAN; ENSEMBL ID: ENSG00000143546; HGNC ID: 10498
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region22489132
GO:0005615IDA-extracellular space16502470
GO:0005634IDA-nucleus21630459
GO:0005829TAS-cytosol22489132
GO:0005856TAS-cytoskeleton22489132
GO:0005886TAS-plasma membrane22489132
GO:0034774TAS-secretory granule lumen-
GO:0045111IDA-intermediate filament cytoskeleton-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0005509TAS-calcium ion binding22489132
GO:0005515IPI-protein binding9867828
GO:0008017TAS-microtubule binding22489132
GO:0008270TAS-zinc ion binding22489132
GO:0035662TAS-Toll-like receptor 4 binding22489132
GO:0050544TAS-arachidonic acid binding22489132
GO:0050786TAS-RAGE receptor binding22489132
GO ID Evidence Qualifier GO_term References
GO:0001816TAS-cytokine production22489132
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002523IDA-leukocyte migration involved in inflammatory response12626582
GO:0002526IEA-acute inflammatory response-
GO:0002544IEA-chronic inflammatory response-
GO:0002793IEA-positive regulation of peptide secretion-
GO:0006914IDA-autophagy19935772
GO:0006915IEA-apoptotic process-
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process19935772
GO:0006954TAS-inflammatory response3313057
GO:0010043IEA-response to zinc ion-
GO:0014002IEA-astrocyte development-
GO:0018119IMP-peptidyl-cysteine S-nitrosylation25417112
GO:0019730TAS-antimicrobial humoral response-
GO:0030307TAS-positive regulation of cell growth22489132
GO:0030593IDA-neutrophil chemotaxis12626582
GO:0032119TAS-sequestering of zinc ion22489132
GO:0032496IEA-response to lipopolysaccharide-
GO:0032602TAS-chemokine production22489132
GO:0042060IEA-wound healing-
GO:0042742TAS-defense response to bacterium22489132
GO:0043312TAS-neutrophil degranulation-
GO:0045087IEA-innate immune response-
GO:0045471IEA-response to ethanol-
GO:0050729IDA-positive regulation of inflammatory response12626582
GO:0050832TAS-defense response to fungus22489132
GO:0051092TAS-positive regulation of NF-kappaB transcription factor activity22489132
GO:0051493TAS-regulation of cytoskeleton organization22489132
GO:0070488IDA-neutrophil aggregation12626582
GO:2001244IDA-positive regulation of intrinsic apoptotic signaling pathway19935772
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
S100A8CHGB11218716169070 Two-hybrid
S100A8CHGB10753916169070 Two-hybrid
S100A8DMWD10810219615732 Affinity Capture-MS
S100A8DMWD11218719615732 Affinity Capture-MS
S100A8GDF911218716169070 Two-hybrid
S100A8GDF910893016169070 Two-hybrid
S100A8PRMT110951216169070 Two-hybrid
S100A8PRMT111218716169070 Two-hybrid
S100A8PPIA11218716169070 Two-hybrid
S100A8PPIA11147416169070 Two-hybrid
S100A8PPM1B11218717353931 Affinity Capture-MS
S100A8PPM1B11149017353931 Affinity Capture-MS
S100A8S100A811218710771424 Co-crystal Structure
C14orf1S100A811218716169070 Two-hybrid
C14orf1S100A811633216169070 Two-hybrid
PDCD11S100A811218716169070 Two-hybrid
PDCD11S100A811663316169070 Two-hybrid
C1orf103S100A811218716169070 Two-hybrid
C1orf103S100A812090516169070 Two-hybrid
TP53S100A811218716169070 Two-hybrid
TP53S100A811301016169070 Two-hybrid
IGSF21S100A811218716169070 Two-hybrid
IGSF21S100A812439616169070 Two-hybrid
UNC119S100A811454816169070 Two-hybrid
UNC119S100A811218716169070 Two-hybrid
ASB3S100A811218717353931 Affinity Capture-MS
ASB3S100A811931717353931 Affinity Capture-MS
MOBKL1BS100A811218717353931 Affinity Capture-MS
MOBKL1BS100A812052717353931 Affinity Capture-MS
USF2S100A811323817353931 Affinity Capture-MS
USF2S100A811218717353931 Affinity Capture-MS
LRRK1S100A811218717353931 Affinity Capture-MS
LRRK1S100A812282317353931 Affinity Capture-MS
NUAK1S100A811218717353931 Affinity Capture-MS
NUAK1S100A811522117353931 Affinity Capture-MS
SLX1BS100A811218719596235 Affinity Capture-MS
SLX1BS100A812247919596235 Affinity Capture-MS
S100A9S100A811218720936779 Two-hybrid
S100A9S100A811218820936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88244
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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