AutismKB 2.0

Annotation Details for CCL2


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Basic Information Top
Gene Symbol:CCL2 ( GDCF-2,HC11,HSMCR30,MCAF,MCP-1,MCP1,MGC9434,SCYA2,SMC-CF )
Gene Full Name: chemokine (C-C motif) ligand 2
Band: 17q12
Quick LinksEntrez ID:6347; OMIM: 158105; Uniprot ID:CCL2_HUMAN; ENSEMBL ID: ENSG00000108691; HGNC ID: 10618
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region20041150
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0005622IEA-intracellular-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity9973507
GO:0005102TAS-receptor binding10542238
GO:0008009IBA-chemokine activity-
GO:0031727ISS-CCR2 chemokine receptor binding-
GO:0031727TAS-CCR2 chemokine receptor binding18021937
GO ID Evidence Qualifier GO_term References
GO:0000165IMP-MAPK cascade21147091
GO:0001525TAS-angiogenesis18334747
GO:0002548IDA-monocyte chemotaxis12207323
GO:0006468TAS-protein phosphorylation9670957
GO:0006935TAS-chemotaxis10623817
GO:0006954IDA-inflammatory response21147091
GO:0006959TAS-humoral immune response9548499
GO:0007010IDA-cytoskeleton organization10072545
GO:0007155TAS-cell adhesion10198043
GO:0007165NAS-signal transduction10770925
GO:0007166TAS-cell surface receptor signaling pathway9548499
GO:0007186TAS-G-protein coupled receptor signaling pathway10542238
GO:0007187TAS-G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger10770925
GO:0007259TAS-JAK-STAT cascade9670957
GO:0008360IDA-regulation of cell shape10072545
GO:0009617NAS-response to bacterium16034137
GO:0009887TAS-animal organ morphogenesis9364936
GO:0019079TAS-viral genome replication10985244
GO:0019221IDA-cytokine-mediated signaling pathway12207323
GO:0019725TAS-cellular homeostasis18334747
GO:0030593IBA-neutrophil chemotaxis-
GO:0031663IDA-lipopolysaccharide-mediated signaling pathway21147091
GO:0034351IDA-negative regulation of glial cell apoptotic process12753088
GO:0035684ISS-helper T cell extravasation-
GO:0036499TAS-PERK-mediated unfolded protein response-
GO:0043491IMP-protein kinase B signaling21147091
GO:0043524IDA-negative regulation of neuron apoptotic process12753088
GO:0043547IBA-positive regulation of GTPase activity-
GO:0043615IDA-astrocyte cell migration12271471
GO:0044344IEP-cellular response to fibroblast growth factor stimulus9407497
GO:0048246IDA-macrophage chemotaxis12207323
GO:0050870ISS-positive regulation of T cell activation-
GO:0051770ISS-positive regulation of nitric-oxide synthase biosynthetic process-
GO:0070098IBA-chemokine-mediated signaling pathway-
GO:0070374IBA-positive regulation of ERK1 and ERK2 cascade-
GO:0071222ISS-cellular response to lipopolysaccharide-
GO:0071346IEP-cellular response to interferon-gamma9407497
GO:0071346ISS-cellular response to interferon-gamma-
GO:0071347IEP-cellular response to interleukin-19407497
GO:0071347ISS-cellular response to interleukin-1-
GO:0071356IEP-cellular response to tumor necrosis factor9407497
GO:0071356ISS-cellular response to tumor necrosis factor-
GO:0071407IDA-cellular response to organic cyclic compound21147091
GO:0090280IDA-positive regulation of calcium ion import10925302
GO:2000427ISS-positive regulation of apoptotic cell clearance-
GO:2000502IDA-negative regulation of natural killer cell chemotaxis7545673
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CCL2CDC611225121383955 Affinity Capture-Western
CCL2CDC610742621383955 Affinity Capture-Western
CCL2CCR31122518642344 Reconstituted Complex
CCL2CCR31076378642344 Reconstituted Complex
CCL2VCAN11225111083865 Reconstituted Complex
CCL2VCAN10784411083865 Reconstituted Complex
CCL2DARC11225113679391 Reconstituted Complex
CCL2DARC10880813679391 Reconstituted Complex
CCL2MCM211225121383955 Affinity Capture-Western
CCL2MCM211033921383955 Affinity Capture-Western
CCL2MCM311225121383955 Affinity Capture-Western
CCL2MCM311034021383955 Affinity Capture-Western
CCL2MCM711225121383955 Affinity Capture-Western
CCL2MCM711034421383955 Affinity Capture-Western
CCL2ORC211225121383955 Affinity Capture-Western
CCL2ORC211104121383955 Affinity Capture-Western
CCL2ORC411104221383955 Affinity Capture-Western
CCL2ORC411225121383955 Affinity Capture-Western
CCL2PCNA11225121383955 Affinity Capture-Western
CCL2PCNA11114221383955 Affinity Capture-Western
CCL2CCL21122517651403 Reconstituted Complex
CCL5CCL211225111350939 Phenotypic Enhancement
CCL5CCL211225511350939 Phenotypic Enhancement
CDC45CCL211225121383955 Affinity Capture-Western
CDC45CCL211391521383955 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CCL2rs1024611 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
CCL2rs1024611 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
CCL2rs1024611 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:98259
  • Data Attributes: MGI curated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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