AutismKB 2.0

Annotation Details for CCL5


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Basic Information Top
Gene Symbol:CCL5 ( D17S136E,MGC17164,RANTES,SCYA5,SISd,TCP228 )
Gene Full Name: chemokine (C-C motif) ligand 5
Band: 17q12
Quick LinksEntrez ID:6352; OMIM: 187011; Uniprot ID:CCL5_HUMAN; ENSEMBL ID: ENSG00000161570; HGNC ID: 10632
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0005737IEA-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004435IDA-phosphatidylinositol phospholipase C activity10734056
GO:0004672IDA-protein kinase activity10734056
GO:0005515IPI-protein binding8699119
GO:0008009IDA-chemokine activity1699135
GO:0008009NAS-chemokine activity7524281
GO:0016004IDA-phospholipase activator activity10734056
GO:0030298IDA-receptor signaling protein tyrosine kinase activator activity10488085
GO:0031726IDA-CCR1 chemokine receptor binding10910894
GO:0031726IPI-CCR1 chemokine receptor binding7545673
GO:0031726TAS-CCR1 chemokine receptor binding9417081
GO:0031729TAS-CCR4 chemokine receptor binding9417081
GO:0031730IPI-CCR5 chemokine receptor binding9139699
GO:0042056IDA-chemoattractant activity15001559
GO:0042379IPI-chemokine receptor binding7517217
GO:0042803IDA-protein homodimerization activity10488085
GO:0043621IDA-protein self-association10488085
GO:0046817IDA-chemokine receptor antagonist activity8631850
GO ID Evidence Qualifier GO_term References
GO:0000165IMP-MAPK cascade21147091
GO:0002407TAS-dendritic cell chemotaxis18337562
GO:0002548IC-monocyte chemotaxis10660125
GO:0002676TAS-regulation of chronic inflammatory response10488085
GO:0006816IDA-calcium ion transport10734056
GO:0006874IDA-cellular calcium ion homeostasis10734056
GO:0006887IDA-exocytosis10734056
GO:0006935NAS-chemotaxis1380064
GO:0006954IDA-inflammatory response21147091
GO:0007159IDA-leukocyte cell-cell adhesion8558019
GO:0007186IDA-G-protein coupled receptor signaling pathway17001303
GO:0007267IDA-cell-cell signaling8558019
GO:0009615TAS-response to virus10488085
GO:0009636IDA-response to toxic substance10841574
GO:0010536TAS-positive regulation of activation of Janus kinase activity11278738
GO:0010759IDA-positive regulation of macrophage chemotaxis16778803
GO:0010820IDA-positive regulation of T cell chemotaxis1699135
GO:0014068IDA-positive regulation of phosphatidylinositol 3-kinase signaling7544376
GO:0014911IDA-positive regulation of smooth muscle cell migration21297082
GO:0030335IDA-positive regulation of cell migration7545673
GO:0030593IBA-neutrophil chemotaxis-
GO:0031328IDA-positive regulation of cellular biosynthetic process18337562
GO:0031584IDA-activation of phospholipase D activity9469451
GO:0031663IDA-lipopolysaccharide-mediated signaling pathway21147091
GO:0033634IDA-positive regulation of cell-cell adhesion mediated by integrin8558019
GO:0034112IDA-positive regulation of homotypic cell-cell adhesion10488085
GO:0042102IDA-positive regulation of T cell proliferation18832695
GO:0042119IDA-neutrophil activation10488085
GO:0042327IDA-positive regulation of phosphorylation18337562
GO:0042531IDA-positive regulation of tyrosine phosphorylation of STAT protein9417081
GO:0043491IMP-protein kinase B signaling21147091
GO:0043547IBA-positive regulation of GTPase activity-
GO:0043623IDA-cellular protein complex assembly18337562
GO:0043922IDA-negative regulation by host of viral transcription10841574
GO:0044344IEP-cellular response to fibroblast growth factor stimulus9407497
GO:0045070TAS-positive regulation of viral genome replication10488085
GO:0045071IDA-negative regulation of viral genome replication10490959
GO:0045089TAS-positive regulation of innate immune response21148810
GO:0045744IDA-negative regulation of G-protein coupled receptor protein signaling pathway10734056
GO:0045785IDA-positive regulation of cell adhesion10910894
GO:0045948NAS-positive regulation of translational initiation18337562
GO:0046427TAS-positive regulation of JAK-STAT cascade11278738
GO:0048245IDA-eosinophil chemotaxis16778803
GO:0048246TAS-macrophage chemotaxis18337562
GO:0048661IDA-positive regulation of smooth muscle cell proliferation21297082
GO:0050679IEA-positive regulation of epithelial cell proliferation-
GO:0050796IDA-regulation of insulin secretion23979485
GO:0050863IDA-regulation of T cell activation10488085
GO:0050918IEA-positive chemotaxis-
GO:0051262IDA-protein tetramerization10488085
GO:0051928IDA-positive regulation of calcium ion transport8699119
GO:0061098IEA-positive regulation of protein tyrosine kinase activity-
GO:0070098IDA-chemokine-mediated signaling pathway17001303
GO:0070098TAS-chemokine-mediated signaling pathway18337562
GO:0070100IEA-negative regulation of chemokine-mediated signaling pathway-
GO:0070233IDA-negative regulation of T cell apoptotic process10488085
GO:0070234IDA-positive regulation of T cell apoptotic process10488085
GO:0070374IBA-positive regulation of ERK1 and ERK2 cascade-
GO:0071346IEP-cellular response to interferon-gamma9407497
GO:0071347IEP-cellular response to interleukin-19407497
GO:0071356IEP-cellular response to tumor necrosis factor9407497
GO:0071407IDA-cellular response to organic cyclic compound21147091
GO:0090026IDA-positive regulation of monocyte chemotaxis1699135
GO:1901214IDA-regulation of neuron death17001303
GO:2000110IEA-negative regulation of macrophage apoptotic process-
GO:2000406IDA-positive regulation of T cell migration23620790
GO:2000503IDA-positive regulation of natural killer cell chemotaxis7545673
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CCL5CCR110763511116158 11449371 Reconstituted Complex
CCL5CCR111225511116158 11449371 Reconstituted Complex
CCL5CCR31076378642344 11449371 Reconstituted Complex
CCL5CCR31122558642344 11449371 Reconstituted Complex
CCL5CCR41076388573157 Reconstituted Complex
CCL5CCR41122558573157 Reconstituted Complex
CCL5CCR510763911116158 11449371 14637022 Affinity Capture-Western; Reconstituted Complex
CCL5CCR511225511116158 11449371 14637022 Affinity Capture-Western; Reconstituted Complex
CCL5CCBP21076439405404 Reconstituted Complex
CCL5CCBP21122559405404 Reconstituted Complex
CCL5VCAN11225511083865 Reconstituted Complex
CCL5VCAN10784411083865 Reconstituted Complex
CCL5IL811225511509627 Reconstituted Complex
CCL5IL810979011509627 Reconstituted Complex
CCL5CCL211225111350939 Phenotypic Enhancement
CCL5CCL211225511350939 Phenotypic Enhancement
SDC1CCL511228414637022 Affinity Capture-Western
SDC1CCL511225514637022 Affinity Capture-Western
SDC4CCL511228614637022 Affinity Capture-Western
SDC4CCL511225514637022 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CCL5rs8069014 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
CCL5rs8069014 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:98262
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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