AutismKB 2.0

Annotation Details for CXCL12


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Basic Information Top
Gene Symbol:CXCL12 ( IRH,PBSF,SCYB12,SDF1,SDF1A,SDF1B,TLSF,TPAR1 )
Gene Full Name: chemokine (C-X-C motif) ligand 12
Band: 10q11.21
Quick LinksEntrez ID:6387; OMIM: 600835; Uniprot ID:SDF1_HUMAN; ENSEMBL ID: ENSG00000107562; HGNC ID: 10672
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005737IEA-cytoplasm-
GO:0009897IBA-external side of plasma membrane-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0005102TAS-receptor binding10358157
GO:0008009IDA-chemokine activity18308860
GO:0008009TAS-chemokine activity12782716
GO:0008083IEA-growth factor activity-
GO:0042056IBA-chemoattractant activity-
GO:0042379IMP-chemokine receptor binding22457824
GO:0045236IDA-CXCR chemokine receptor binding20388803
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0001764IEA-neuron migration-
GO:0001938IEA-positive regulation of endothelial cell proliferation-
GO:0006874TAS-cellular calcium ion homeostasis10772939
GO:0006935TAS-chemotaxis12782716
GO:0006952IEA-defense response-
GO:0006955IEA-immune response-
GO:0007155TAS-cell adhesion10198043
GO:0007165TAS-signal transduction10491003
GO:0007186TAS-G-protein coupled receptor signaling pathway8752280
GO:0007411IBA-axon guidance-
GO:0008015TAS-blood circulation10772939
GO:0008064TAS-regulation of actin polymerization or depolymerization10570282
GO:0008344IEA-adult locomotory behavior-
GO:0009314IEA-response to radiation-
GO:0009408IEA-response to heat-
GO:0009615TAS-response to virus10772939
GO:0022029IEA-telencephalon cell migration-
GO:0031100IEA-animal organ regeneration-
GO:0033603IEA-positive regulation of dopamine secretion-
GO:0043434IEA-response to peptide hormone-
GO:0045785IDA-positive regulation of cell adhesion23620790
GO:0048842IEA-positive regulation of axon extension involved in axon guidance-
GO:0050918IEA-positive chemotaxis-
GO:0050930IBA-induction of positive chemotaxis-
GO:0060326IDA-cell chemotaxis18308860
GO:0070098IDA-chemokine-mediated signaling pathway20388803
GO:0090026IDA-positive regulation of monocyte chemotaxis18802065
GO:0090280TAS-positive regulation of calcium ion import10925302
GO:1902230IDA-negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage20388803
GO:1903237IDA-negative regulation of leukocyte tethering or rolling18308860
GO:1990478IEA-response to ultrasound-
GO:2000107IDA-negative regulation of leukocyte apoptotic process15059845
GO:2000406IDA-positive regulation of T cell migration23620790
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CXCL12VCAN11228811083865 Reconstituted Complex
CXCL12VCAN10784411083865 Reconstituted Complex
CXCL12FN111228811023498 Reconstituted Complex
CXCL12FN110862111023498 Reconstituted Complex
CXCL12PF411228810233851 Reconstituted Complex
CXCL12PF411121910233851 Reconstituted Complex
CXCL12CXCL1211228810954912 Co-crystal Structure
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CXCL12rs501120 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:103556
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030318-1'