AutismKB 2.0

Annotation Details for MAP2K4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP2K4 ( JNKK,JNKK1,MAPKK4,MEK4,MKK4,PRKMK4,SEK1,SERK1 )
Gene Full Name: mitogen-activated protein kinase kinase 4
Band: 17p12
Quick LinksEntrez ID:6416; OMIM: 601335; Uniprot ID:MP2K4_HUMAN; ENSEMBL ID: ENSG00000065559; HGNC ID: 6844
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IBA-cytoplasm-
GO:0005829TAS-cytosol-
GO:0030424IEA-axon-
GO:0032839IEA-dendrite cytoplasm-
GO:0043204IEA-perikaryon-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity7716521
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0004713IEA-protein tyrosine kinase activity-
GO:0005515IPI-protein binding9808624
GO:0005524IEA-ATP binding-
GO:0008545IEA-JUN kinase kinase activity-
GO:0031435IEA-mitogen-activated protein kinase kinase kinase binding-
GO ID Evidence Qualifier GO_term References
GO:0006915IEA-apoptotic process-
GO:0007165TAS-signal transduction7716521
GO:0007254TAS-JNK cascade-
GO:0007257IEA-activation of JUN kinase activity-
GO:0009611IEA-response to wounding-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0034393IEA-positive regulation of smooth muscle cell apoptotic process-
GO:0035897TAS-proteolysis in other organism-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043525IEA-positive regulation of neuron apoptotic process-
GO:0045740IEA-positive regulation of DNA replication-
GO:0051770IEA-positive regulation of nitric-oxide synthase biosynthetic process-
GO:0061049IEA-cell growth involved in cardiac muscle cell development-
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0072709IEA-cellular response to sorbitol-
GO:2000672IEA-negative regulation of motor neuron apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP2K4AKT110671011707464 Affinity Capture-Western; Biochemical Activity
MAP2K4AKT111231511707464 Affinity Capture-Western; Biochemical Activity
MAP2K4ARRB210690211090355 Affinity Capture-Western
MAP2K4ARRB211231511090355 Affinity Capture-Western
MAP2K4MAP3K81123158631303 Biochemical Activity
MAP2K4MAP3K81077198631303 Biochemical Activity
MAP2K4FLNC1086079006895 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP2K4FLNC1123159006895 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP2K4MAP3K111037810713157 Affinity Capture-Western
MAP2K4MAP3K111231510713157 Affinity Capture-Western
MAP2K4MAP3K41103809841871 Biochemical Activity
MAP2K4MAP3K41123159841871 Biochemical Activity
MAP2K4MAP3K101104409182538 Biochemical Activity
MAP2K4MAP3K101123159182538 Biochemical Activity
MAP2K4MAP3K1111044210187804 Biochemical Activity
MAP2K4MAP3K1111231510187804 Biochemical Activity
MAP2K4NPHS111092811562357 Phenotypic Suppression
MAP2K4NPHS111231511562357 Phenotypic Suppression
MAP2K4MAPK81115859207092 10713157 11279118 11707464 12391307 Affinity Capture-Western; Biochemical Activity; Phenotypic Enhancement; Reconstituted Complex
MAP2K4MAPK81123159207092 10713157 11279118 11707464 12391307 Affinity Capture-Western; Biochemical Activity; Phenotypic Enhancement; Reconstituted Complex
MAP2K4MAP2K711159511062067 Phenotypic Enhancement
MAP2K4MAP2K711231511062067 Phenotypic Enhancement
MAP2K4MAP4K21118099712898 Reconstituted Complex
MAP2K4MAP4K21123159712898 Reconstituted Complex
MAPK8IP3MAP2K411231510523642 12189133 Affinity Capture-Western
MAPK8IP3MAP2K411677410523642 12189133 Affinity Capture-Western
MAP3K2MAP2K411596910713157 Affinity Capture-Western
MAP3K2MAP2K411231510713157 Affinity Capture-Western
SPAG9MAP2K411450512391307 Affinity Capture-Western
SPAG9MAP2K411231512391307 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
MAP2K4MAPK819372012659851 MKK4 phosphorylates JNK1. This interaction was modeled on a demonstrated interaction between MKK4 from an unspecified species and JNK1 from an unpsecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346869
  • Data Attributes: MGI curated and HomoloGene calculated
No data