AutismKB 2.0

Annotation Details for SFRP1


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Basic Information Top
Gene Symbol:SFRP1 ( FRP,FRP-1,FRP1,FrzA,SARP2 )
Gene Full Name: secreted frizzled-related protein 1
Band: 8p11.21
Quick LinksEntrez ID:6422; OMIM: 604156; Uniprot ID:SFRP1_HUMAN; ENSEMBL ID: ENSG00000104332; HGNC ID: 10776
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005578IDA-proteinaceous extracellular matrix9192640
GO:0005615IDA-extracellular space9192640
GO:0005622IDA-intracellular17500071
GO:0005829IDA-cytosol14581477
GO:0005886ISS-plasma membrane-
GO:0009986IDA-cell surface9192640
GO:0031012IDA-extracellular matrix10347172
GO:0031012IDAcolocalizes_withextracellular matrix20551380
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0004197IMP-cysteine-type endopeptidase activity14581477
GO:0005109IPI-frizzled binding1927703
GO:0005515IPI-protein binding10347172
GO:0008144IDA-drug binding19072540
GO:0008201IDA-heparin binding9192640
GO:0017147IDA-Wnt-protein binding17462603
GO:0017147IPI-Wnt-protein binding10347172
GO:0017147NAS-Wnt-protein binding24431302
GO:0042802IPI-identical protein binding10347172
GO ID Evidence Qualifier GO_term References
GO:0001649IEP-osteoblast differentiation16149051
GO:0001657IEA-ureteric bud development-
GO:0001954ISS-positive regulation of cell-matrix adhesion-
GO:0002244IDA-hematopoietic progenitor cell differentiation19778523
GO:0006508IEA-proteolysis-
GO:0008284IDA-positive regulation of cell proliferation10980594
GO:0008285IDA-negative regulation of cell proliferation10347172
GO:0008584IEA-male gonad development-
GO:0008585IEA-female gonad development-
GO:0009267IEP-cellular response to starvation9724099
GO:0009950IDA-dorsal/ventral axis specification9192640
GO:0010564IMP-regulation of cell cycle process9724099
GO:0010629IDA-negative regulation of gene expression10980594
GO:0010719IDA-negative regulation of epithelial to mesenchymal transition19095296
GO:0010975IEA-regulation of neuron projection development-
GO:0014034IEA-neural crest cell fate commitment-
GO:0014070IDA-response to organic cyclic compound20208569
GO:0022601IEP-menstrual cycle phase11932307
GO:0030177IDA-positive regulation of Wnt signaling pathway10660608
GO:0030178IDA-negative regulation of Wnt signaling pathway9192640
GO:0030178IMP-negative regulation of Wnt signaling pathway19072540
GO:0030178NAS-negative regulation of Wnt signaling pathway24431302
GO:0030279IDA-negative regulation of ossification15677765
GO:0030279IMP-negative regulation of ossification19254787
GO:0030307IDA-positive regulation of cell growth10980594
GO:0030308IDA-negative regulation of cell growth19569235
GO:0030336IDA-negative regulation of cell migration10980594
GO:0030514IEA-negative regulation of BMP signaling pathway-
GO:0033689IMP-negative regulation of osteoblast proliferation19072540
GO:0035019IEA-somatic stem cell population maintenance-
GO:0042493IDA-response to drug19072540
GO:0043065IDA-positive regulation of apoptotic process9391078
GO:0043065IMP-positive regulation of apoptotic process9724099
GO:0043066IMP-negative regulation of apoptotic process11932307
GO:0043508IEA-negative regulation of JUN kinase activity-
GO:0043547ISS-positive regulation of GTPase activity-
GO:0044344IDA-cellular response to fibroblast growth factor stimulus17500071
GO:0044345IEA-stromal-epithelial cell signaling involved in prostate gland development-
GO:0045578IMP-negative regulation of B cell differentiation18941195
GO:0045600IDA-positive regulation of fat cell differentiation12055200
GO:0045668IEA-negative regulation of osteoblast differentiation-
GO:0045671IEA-negative regulation of osteoclast differentiation-
GO:0045765ISS-regulation of angiogenesis-
GO:0045880IMP-positive regulation of smoothened signaling pathway17035233
GO:0045892IDA-negative regulation of transcription, DNA-templated10660608
GO:0045892IMP-negative regulation of transcription, DNA-templated16532032
GO:0045893IDA-positive regulation of transcription, DNA-templated10660608
GO:0045893IMP-positive regulation of transcription, DNA-templated19723665
GO:0046676IDA-negative regulation of insulin secretion17994217
GO:0046851IMP-negative regulation of bone remodeling19072540
GO:0048147IDA-negative regulation of fibroblast proliferation19734317
GO:0048546IEA-digestive tract morphogenesis-
GO:0050679IMP-positive regulation of epithelial cell proliferation16288033
GO:0050680IDA-negative regulation of epithelial cell proliferation19095296
GO:0050732IDA-negative regulation of peptidyl-tyrosine phosphorylation10980594
GO:0051496ISS-positive regulation of stress fiber assembly-
GO:0051894ISS-positive regulation of focal adhesion assembly-
GO:0060070IDA-canonical Wnt signaling pathway18787224
GO:0060218IDA-hematopoietic stem cell differentiation19778523
GO:0060346IEA-bone trabecula formation-
GO:0060527IEA-prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis-
GO:0060687IEA-regulation of branching involved in prostate gland morphogenesis-
GO:0060766IDA-negative regulation of androgen receptor signaling pathway19277043
GO:0071305IEP-cellular response to vitamin D16149051
GO:0071347IEP-cellular response to interleukin-116149051
GO:0071356IDA-cellular response to tumor necrosis factor9391078
GO:0071363IDA-cellular response to growth factor stimulus17500071
GO:0071380IEP-cellular response to prostaglandin E stimulus16149051
GO:0071391IDA-cellular response to estrogen stimulus18941195
GO:0071392IEP-cellular response to estradiol stimulus11932307
GO:0071456IEP-cellular response to hypoxia11932307
GO:0071481IEA-cellular response to X-ray-
GO:0071504IDA-cellular response to heparin17500071
GO:0071542IEA-dopaminergic neuron differentiation-
GO:0071560IEP-cellular response to transforming growth factor beta stimulus16149051
GO:0071773IEP-cellular response to BMP stimulus16149051
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway9391078
GO:0090090IGI-negative regulation of canonical Wnt signaling pathway17462603
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway9724099
GO:0090179IEA-planar cell polarity pathway involved in neural tube closure-
GO:0090244IEA-Wnt signaling pathway involved in somitogenesis-
GO:0090246IEA-convergent extension involved in somitogenesis-
GO:0090263IDA-positive regulation of canonical Wnt signaling pathway18941195
GO:0090263IGI-positive regulation of canonical Wnt signaling pathway24080158
GO:1902043IDA-positive regulation of extrinsic apoptotic signaling pathway via death domain receptors9391078
GO:1904956IEA-regulation of midbrain dopaminergic neuron differentiation-
GO:2000041IEA-negative regulation of planar cell polarity pathway involved in axis elongation-
GO:2000052IDA-positive regulation of non-canonical Wnt signaling pathway19569235
GO:2000054IDA-negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification9192640
GO:2000080IDA-negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation17994217
GO:2000270IDA-negative regulation of fibroblast apoptotic process14581477
GO:2000271IDA-positive regulation of fibroblast apoptotic process14581477
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WNT1SFRP111330810347172 Affinity Capture-Western
WNT1SFRP111232010347172 Affinity Capture-Western
WNT2SFRP111330910347172 Affinity Capture-Western
WNT2SFRP111232010347172 Affinity Capture-Western
FZD6SFRP111391910347172 Affinity Capture-Western
FZD6SFRP111232010347172 Affinity Capture-Western
WNT4SFRP111993911287180 Reconstituted Complex
WNT4SFRP111232011287180 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
SFRP1rs3242, rs7833518, rs921143 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:892014
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040310-5'